scholarly journals Improved prediction of postoperative paediatric cerebellar mutism syndrome using an artificial neural network

Author(s):  
Jai Sidpra ◽  
Adam P Marcus ◽  
Ulrike Löbel ◽  
Sebastian M Toescu ◽  
Derek Yecies ◽  
...  

Abstract Background Postoperative paediatric cerebellar mutism syndrome (pCMS) is a common but severe complication which may arise following the resection of posterior fossa tumours in children. Two previous studies have aimed to preoperatively predict pCMS, with varying results. In this work, we examine the generalisation of these models and determine if pCMS can be predicted more accurately using an artificial neural network (ANN). Methods An overview of reviews was performed to identify risk factors for pCMS, and a retrospective dataset collected as per these defined risk factors from children undergoing resection of primary posterior fossa tumours. The ANN was trained on this dataset and its performance evaluated in comparison to logistic regression and other predictive indices via analysis of receiver operator characteristic curves. Area under the curve (AUC) and accuracy were calculated and compared using a Wilcoxon signed rank test, with p<0.05 considered statistically significant. Results 204 children were included, of whom 80 developed pCMS. The performance of the ANN (AUC 0.949; accuracy 90.9%) exceeded that of logistic regression (p<0.05) and both external models (p<0.001). Conclusion Using an ANN, we show improved prediction of pCMS in comparison to previous models and conventional methods.

2021 ◽  
Vol 9 ◽  
Author(s):  
Brett Snider ◽  
Edward A. McBean ◽  
John Yawney ◽  
S. Andrew Gadsden ◽  
Bhumi Patel

The Severe Acute Respiratory Syndrome Coronavirus 2 pandemic has challenged medical systems to the brink of collapse around the globe. In this paper, logistic regression and three other artificial intelligence models (XGBoost, Artificial Neural Network and Random Forest) are described and used to predict mortality risk of individual patients. The database is based on census data for the designated area and co-morbidities obtained using data from the Ontario Health Data Platform. The dataset consisted of more than 280,000 COVID-19 cases in Ontario for a wide-range of age groups; 0–9, 10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, 80–89, and 90+. Findings resulting from using logistic regression, XGBoost, Artificial Neural Network and Random Forest, all demonstrate excellent discrimination (area under the curve for all models exceeded 0.948 with the best performance being 0.956 for an XGBoost model). Based on SHapley Additive exPlanations values, the importance of 24 variables are identified, and the findings indicated the highest importance variables are, in order of importance, age, date of test, sex, and presence/absence of chronic dementia. The findings from this study allow the identification of out-patients who are likely to deteriorate into severe cases, allowing medical professionals to make decisions on timely treatments. Furthermore, the methodology and results may be extended to other public health regions.


Author(s):  
W. Abdul Hameed ◽  
Anuradha D. ◽  
Kaspar S.

Breast tumor is a common problem in gynecology. A reliable test for preoperative discrimination between benign and malignant breast tumor is highly helpful for clinicians in culling the malignant cells through felicitous treatment for patients. This paper is carried out to generate and estimate both logistic regression technique and Artificial Neural Network (ANN) technique to predict the malignancy of breast tumor, utilizing Wisconsin Diagnosis Breast Cancer Database (WDBC). Our aim in this Paper is: (i) to compare the diagnostic performance of both methods in distinguishing between malignant and benign patterns, (ii) to truncate the number of benign cases sent for biopsy utilizing the best model as an auxiliary implement, and (iii) to authenticate the capability of each model to recognize incipient cases as an expert system.


2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Edgard Efren Lozada Hernandez ◽  
Tania Aglae Ramírez del Real ◽  
Dagoberto Armenta Medina ◽  
Jose Francisco Molina Rodriguez ◽  
Juan ramon Varela Reynoso

Abstract Aim “Incisional Hernia (IH) has an incidence of 10-23%, which can increase to 38% in specific risk groups. The objective of this study was developed and validated an artificial neural network (ANN) model for the prediction of IH after midline laparotomy (ML) and this model can be used by surgeons to help judge a patient’s risk for IH.” Material and Methods “A retrospective, single arm, observational cohort trial was conducted from January 2016 to December 2020. Study participants were recruited from patients undergoing ML for elective or urgent surgical indication. Using logistic regression and ANN models, we evaluated surgical treated IH, wound dehiscence, morbidity, readmission, and mortality using the area under the receiver operating characteristic curves, true-positive rate, true-negative rate, false-positive rate, and false-negative rates.” Results “There was no significant difference in the power of the ANN and logistic regression for predicting IH, wound dehiscence, mortality, readmission, and all morbidities after ML. The resulting model consisted of 4 variables: surgical site infection, emergency surgery, previous laparotomy, and BMI(Kg/m2) > 26. The patient with the four positive factors has a 73% risk of developing incisional hernia. The area under the curve was 0.82 (95% IC 0.76-0.87). Conclusions “ANNs perform comparably to logistic regression models in the prediction of IH. ANNs may be a useful tool in risk factor analysis of IH and clinical applications.”


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