A multidimensional cross-sectional analysis of COVID-19 seroprevalence among a police officer cohort: The PoliCOV-19 study

Abstract Background Protests and police fieldwork provides a high exposure environment for SARS-CoV-2 infections. In this cross-sectional analysis, we investigated the seroprevalence among a police cohort, and sociodemographic, work and health-related factors associated with seropositivity. Methods Study participants were invited for serological testing of SARS-CoV-2 and to complete online questionnaires. Serum neutralization titres towards the wild-type SARS-CoV-2 spike protein (expressing D614G) and the alpha and beta variants were measured in seropositive study participants. Results 978 police personnel representing 35% of the entire staff participated from February to March 2021. The seroprevalence was 12.9%. It varied by geographic region within the canton; ranged from 9% to 13.5% in three regions, including the city; and was 22% in Bernese Seeland/Jura with higher odds for seropositivity (OR 2.38, 95% CI 1.28–4.44, P=0.006). Job roles with mainly office activity were associated with a lower risk of seropositivity (0.33, 0.14–0.77, P=0.010). Most seropositive employees (67.5%) reported having had COVID-19 three months or longer prior to serological testing. Selfreported compliance with mask wearing during working hours was 100%; 45% of all seropositive versus 5% of all seronegative participants (P<0.001) reported having had contact with a proven COVID-19 case living in the same household prior to serological testing. The level of serum antibody titres correlated with neutralization capacity. Antibodies derived from natural SARS-CoV-2 infection effectively neutralized the SARS-CoV-2 spike protein, but were less effective against the alpha and beta variants. Conclusions The seroprevalence of anti-SARS-CoV-2 antibodies of police officers was comparable to that reported in the general population, suggesting that the personal protective equipment of the police is effective, and that household contacts are the leading transmission venues. The level of serum antibody titres, in particular that of anti-spike antibodies, correlated well with neutralization capacity. Low antibody titres acquired from natural infection were not effective against variants.

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A multidimensional cross-sectional analysis of COVID-19 seroprevalence among a police officer cohort: The PoliCOV-19 study

10.1101/2021.08.09.21261789 ◽

2021 ◽

Author(s):

Parham Sendi ◽

Rossella Baldan ◽

Marc Thierstein ◽

Nadja Widmer ◽

Peter Gowland ◽

...

Keyword(s):

Odds Ratio ◽

Serum Antibody ◽

Working Hours ◽

Serological Testing ◽

Cross Sectional ◽

Neutralization Capacity ◽

Work Related ◽

Antibody Titres ◽

Study Participants ◽

Sectional Analysis

OBJECTIVE: To determine the seroprevalence of SARS-CoV-2 antibodies in employees of the Cantonal Police Bern, Switzerland; to investigate individual and work-related factors associated with seropositivity; and to assess the neutralizing capacity of the antibodies of seropositive study participants. DESIGN: Cross-sectional analysis of a cohort study. SETTING: Wearing face masks was made mandatory for employees of the police during working hours at the rise of the second wave of the pandemic in mid-October 2020. Protests and police fieldwork provided a high exposure environment for SARS-CoV-2 infections. The investigation was performed prior to initiation of a vaccine programme. Study participants were invited for serological testing of SARS-CoV-2 and to complete questionnaires on sociodemographic, work and health-related questions. PARTICIPANTS: 978 police personnel working in four different geographic districts, representing 35% of the entire staff, participated from February to March 2021. MAIN OUTCOME MEASURES: Seroprevalence of anti-SARS-CoV-2 antibodies in February to March 2021, geographic and work-related risk factors for seropositivity, and serum neutralization titres towards the wild-type SARS-CoV-2 spike protein (expressing D614G) and the alpha and beta variants. RESULTS: Seroprevalence was 12.9% (126 of 978 employees). It varied by geographic region within the canton; ranged from 9% to 13% in three regions, including the city; and was 22% in Bernese Seeland/Jura. Working in the latter region was associated with higher odds for seropositivity (odds ratio 2.38, 95% confidence interval 1.28 to 4.44, P=0.006). Job roles with mainly office activity were associated with a lower risk of seropositivity (0.33, 0.14 to 0.77, P=0.010). Most seropositive employees (67.5%) reported having had coronavirus disease 2019 (COVID-19) 3 months or longer prior to serological testing, and the proportion of agreement between positive nasopharyngeal test results and seroconversion was 95% to 97%. Among reported symptoms, new loss of smell or taste was the best discriminator for seropositivity (odds ratio 52.4, 30.9 to 89.0, P<0.001). Compliance with mask wearing during working hours was 100%, and 45% of all seropositive versus 5% of all seronegative participants (P<0.001) reported having had contact with a proven COVID-19 case living in the same household. The level of serum antibody titres correlated well with neutralization capacity. Antibodies derived from natural SARS-CoV-2 infection effectively neutralized the SARS-CoV-2 spike protein (expressing D614G), but were less effective against the alpha and beta variants. A regression model demonstrated that anti-spike antibodies had higher odds for neutralization than did anti-nucleocapsid protein antibodies. CONCLUSIONS: Seroprevalence in the pre-vaccinated police cohort was similar to that reported in the general population living in the same region. The high compliance with mask wearing and the low proportion of seroconversion after contact with a presumed or proven COVID-19 case during working hours imply that personal protective equipment is effective and that household contacts are the leading transmission venues. The level of serum antibody titres, in particular that of anti-spike antibodies, correlated well with neutralization capacity. Low antibody titres were not effective against the alpha and beta variants.

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The older the better: are elderly study participants more non-representative? A cross-sectional analysis of clinical trial and observational study samples

BMJ Open ◽

10.1136/bmjopen-2012-000833 ◽

2012 ◽

Vol 2 (6) ◽

pp. e000833 ◽

Cited By ~ 43

Author(s):

Beatrice A Golomb ◽

Virginia T Chan ◽

Marcella A Evans ◽

Sabrina Koperski ◽

Halbert L White ◽

...

Keyword(s):

Clinical Trial ◽

Observational Study ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Study Participants ◽

Sectional Analysis

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Quantifying satisfaction among pharmacists working in Pharmaceutical Sales or Marketing and its inferential relationship with demographics: A Cross-Sectional analysis in Pakistan

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.37.2.3447 ◽

2021 ◽

Vol 37 (2) ◽

Author(s):

Muhammad Hammad Butt ◽

Shahzadi Misbah ◽

Abrar Ahmad ◽

Tooba Mehboob ◽

Irfan Bashir

Keyword(s):

Cross Sectional Study ◽

Health Condition ◽

Satisfaction Score ◽

Cross Sectional ◽

Pharmaceutical Sales ◽

Factors Associated ◽

Creative Commons ◽

Cross Sectional Analysis ◽

Study Participants ◽

Sectional Analysis

Objectives: To quantify satisfaction among pharmacists working in pharmaceutical sales or marketing in Pakistan. Methods: A cross-sectional study was conducted among pharmacists working in pharmaceutical sales and marketing during August to November, 2019. Satisfaction score of pharmacists was considered satisfied (Score > 2.5) and dissatisfied (Score < 2.5). The maximum and minimum satisfaction score was four and one for each question respectively. Results: A total of 250 questionnaires were distributed and 200 were received back yielding a response rate of 80%. Male respondents dominated the cohort and were more satisfied (2.60 ± 0.47) as compared to females (2.31 ± 0.48) with majority were 18-30 years old and 78% had Pharm. D level of education (2.61 ± 0.47). The mean satisfaction score of participant is 2.51 with standard deviation of 0.49. The 53% of the respondents were dissatisfied with their salaries. The study dependent and independent variables are correlated with each other and significant results were seen between them. The factors associated with dissatisfaction are fear of losing job (2.19 ± 0.88), switch job (2.20 ± 0.77) and health condition (2.09 ± 0.89). Factors associated with satisfaction are positive attitude of doctor (2.91 ± 0.60), doctor consider respectful job holder (2.91 ± 0.61), enjoy work (3.01 ± 0.65), job by choice (3.12 ± 0.67) and progress in job (3.00 ± 0.74). Conclusions: It was concluded that the respondents were dissatisfied due to number of issues including disturbance in their personal life, lack of promotion and incentives among study participants. doi: https://doi.org/10.12669/pjms.37.2.3447 How to cite this:Butt MH, Misbah S, Ahmad A, Mehboob T, Bashir I. Quantifying satisfaction among pharmacists working in Pharmaceutical Sales or Marketing and its inferential relationship with demographics: A Cross-Sectional analysis in Pakistan. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3447 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Evaluation of the prevalence and nutritional and social determinants of overweight in a population of schoolchildren: a cross-sectional analysis of 5,037 children

Revista da Associação Médica Brasileira ◽

10.1016/s0104-4230(12)70231-2 ◽

2012 ◽

Vol 58 (4) ◽

pp. 472-476 ◽

Cited By ~ 5

Author(s):

Caroline Filla Rosaneli ◽

Flavia Auler ◽

Carla Barreto Manfrinato ◽

Claudine Filla Rosaneli ◽

Caroline Sganzerla ◽

...

Keyword(s):

Social Determinants ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Sectional Analysis

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Quantitative Clinical Characteristics of 53 Patients with MPS VII: A Cross-Sectional Analysis

Neuropediatrics ◽

10.1055/s-0037-1602914 ◽

2017 ◽

Vol 48 (S 01) ◽

pp. S1-S45

Author(s):

M. Zielonka ◽

S. Garbade ◽

S. Kölker ◽

G. Hoffmann ◽

M. Ries

Keyword(s):

Clinical Characteristics ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Mps Vii ◽

Sectional Analysis

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Fracture prevalence in children 0-19 years-old in Mexico: A 10-year cross-sectional analysis

Bone Abstracts ◽

10.1530/boneabs.7.p109 ◽

2019 ◽

Author(s):

Patricia Clark ◽

Annarella Barbato ◽

Miguel Angel Guagnelli ◽

Jose Alberto Rascon ◽

Edgar Denova ◽

...

Keyword(s):

Cross Sectional ◽

Cross Sectional Analysis ◽

Fracture Prevalence ◽

Sectional Analysis

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2174-PUB: Profiling of Young Diabetes in India: A Cross-Sectional Analysis Report

Diabetes ◽

10.2337/db20-2174-pub ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 2174-PUB

Author(s):

NARAYANAN NK ◽

CS DWARAKANATH ◽

VENKATARAMAN S ◽

MANIKANDAN RM ◽

NARENDRA BS ◽

...

Keyword(s):

Cross Sectional ◽

Cross Sectional Analysis ◽

Sectional Analysis

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Quantitative Electrical Analysis of FIB Prepared Vias on BiCMOS and CMOS090 Designs

ISTFA 2006: Conference Proceedings from the 32nd International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa2006p0067 ◽

2006 ◽

Author(s):

B. Domengès ◽

P. Poirier

Keyword(s):

Ion Beam ◽

Beam Current ◽

Kelvin Probe ◽

Metal Line ◽

Cross Sectional ◽

Probe Technique ◽

Cross Sectional Analysis ◽

Controlling Parameter ◽

Electrical Analysis ◽

Sectional Analysis

Abstract In this study, the resistance of FIB prepared vias was characterized by the Kelvin probe technique and their physical characteristics studied using cross-sectional analysis. Two domains of resistivity were isolated in relation to the ion beam current used for the deposition of the via metal (Pt). Also submicrometer vias were investigated on 4.2 µm deep metal lines of a BiCMOS aluminum based design and a CMOS 090 copper based one. It is shown that the controlling parameter is the shape and volume of the contact, and that the contact formation is favored by the amount of over-mill of the via into the metal line it will contact.

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