scholarly journals Calcium responses elicited in human T cells and dendritic cells by cell–cell interaction and soluble ligands

1999 ◽  
Vol 11 (10) ◽  
pp. 1725-1726 ◽  
Author(s):  
Monica Montes ◽  
Dorian McIlroy ◽  
Anne Hosmalin ◽  
Alain Trautmann
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cell Interaction ◽  
Human T Cells ◽  
Cell Cell

scholarly journals Calcium responses elicited in human T cells and dendritic cells by cell–cell interaction and soluble ligands

1999 ◽  
Vol 11 (4) ◽  
pp. 561-568 ◽  
Author(s):  
Mônica Montes ◽  
Dorian McIlroy ◽  
Anne Hosmalin ◽  
Alain Trautmann
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cell Interaction ◽  
Human T Cells ◽  
Cell Cell

Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21

2016 ◽  
Vol 94 (10) ◽  
pp. 955-963 ◽  
Author(s):  
Natalie Lorenz ◽  
Evert Jan Loef ◽  
Inken D Kelch ◽  
Daniel J Verdon ◽  
Moyra M Black ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Plasmin Activity ◽  
Migratory Capacity ◽  
Human T Cells

scholarly journals Differential Responses to IFN-α Subtypes in Human T Cells and Dendritic Cells

2003 ◽  
Vol 171 (10) ◽  
pp. 5255-5263 ◽  
Author(s):  
Catharien M. U. Hilkens ◽  
Jörg F. Schlaak ◽  
Ian M. Kerr
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Human T Cells ◽  
Differential Responses

scholarly journals Acquisition of CD80 by Human T Cells at Early Stages of Activation: Functional Involvement of CD80 Acquisition in T Cell to T Cell Interaction

2002 ◽  
Vol 169 (11) ◽  
pp. 6162-6169 ◽  
Author(s):  
Zohreh Tatari-Calderone ◽  
Roshanak Tolouei Semnani ◽  
Thomas B. Nutman ◽  
Jeffrey Schlom ◽  
Helen Sabzevari
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Interaction ◽  
Early Stages ◽  
Human T Cells ◽  
Functional Involvement

scholarly journals Dendritic Cells Induce MUC1 Expression and Polarization on Human T Cells by an IL-7-Dependent Mechanism

2005 ◽  
Vol 174 (4) ◽  
pp. 2376-2386 ◽  
Author(s):  
Baldev Vasir ◽  
David Avigan ◽  
Zekui Wu ◽  
Keith Crawford ◽  
Shawn Turnquist ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Muc1 Expression ◽  
Human T Cells ◽  
Dependent Mechanism

scholarly journals Peptide-pulsed dendritic cells induce the hepatitis C viral epitope-specific responses of naïve human T cells

Vaccine ◽  
2014 ◽  
Vol 32 (26) ◽  
pp. 3285-3292 ◽  
Author(s):  
Sasmita Mishra ◽  
Phyllis T. Losikoff ◽  
Alyssa A. Self ◽  
Frances Terry ◽  
Matthew T. Ardito ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Hepatitis C ◽  
Viral Epitope ◽  
Human T Cells

scholarly journals A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Enas Abu-Shah ◽  
Philippos Demetriou ◽  
Štefan Bálint ◽  
Viveka Mayya ◽  
Mikhail A Kutuzov ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Immune Cell ◽  
Population Based ◽  
Functional Responses ◽  
Human Immunology ◽  
Human T Cells ◽  
Activation Dynamics ◽  
Effect Of Pd

Research in the field of human immunology is restricted by the lack of a system that reconstitutes the in-situactivation dynamics of quiescent human antigen-specific T-cells interacting with dendritic cells. Here we report a tissue-like system that recapitulates the dynamics of engineered primary human immune cell. Our approach facilitates real-time single-cell manipulations, tracking of interactions and functional responses complemented by population-based measurements of cytokines, activation status and proliferation. As a proof of concept, we recapitulate immunological phenomenon such as CD4 T-cells' help to CD8 T-cells through enhanced maturation of DCs and the effect of PD-1 checkpoint blockades. In addition, we characterise unique dynamics of T-cell/DC interactions as a function of antigen affinity.

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