scholarly journals The therapeutic role of acellular dermal matrix seeded with mesenchymal stem cells versus autologous skin graft in healing of skin defect

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
G F Mohamed ◽  
M H Manal ◽  
S Omar ◽  
A A Abo Zeid ◽  
B M Walaa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Skin Graft ◽  
Acellular Dermal Matrix ◽  
Skin Defect ◽  
Dermal Matrix ◽  
Therapeutic Role ◽  
Acellular Dermal

Construction of Tissue Engineered Skin with VEGF-Modified Human Mesenchymal Stem Cells and Acellular Dermal Matrix

2009 ◽  
Vol 610-613 ◽  
pp. 1298-1301
Author(s):  
Xiang Rong Zhang ◽  
De Wu Liu ◽  
Guang Hua Guo ◽  
Yan Peng
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gradient Centrifugation ◽  
Human Mesenchymal Stem Cells ◽  
Acellular Dermal Matrix ◽  
Culture Method ◽  
Gene Encoding ◽  
Dermal Matrix ◽  
Acellular Dermal

The development of skin tissue engineering provides a noninvasive method for skin restoration. Unfortunately, the lack of a vascular plexus leads to greater time for vascularization compared with native skin autografts and contributes to graft failure. Our purpose was to construct tissue-engineered skin with VEGF- modified human bone marrow mesenchymal stem cells (hMSCs) as well as acellular dermal matrix(ADM) in vitro , Thus by increased vascular endothelial growth factor expression, which could prospectively improve vascularization of tissue-engineered skin for wound healing applications. To reach this aim, hMSCs were isolated and cultured with density gradient centrifugation combined with attachment culture method in vitro. Liposome- mediated gene transfer was used to generate a population of hMSCs overexpressing the gene encoding VEGF165. Then VEGF- modified hMSCs were seeded onto the surface of ADM. The experimental results showed that ADM we prepared has good compatibility with MSCs, the cells in ADM grew and proliferated well in vitro and the tissue - engineered skin with VEGF- modified hMSCs and ADM has been successfully constructed.

Synthesis of a Tissue-Engineered Periosteum with Acellular Dermal Matrix and Cultured Mesenchymal Stem Cells

2009 ◽  
Vol 15 (7) ◽  
pp. 1833-1841 ◽  
Author(s):  
Björn Schönmeyr ◽  
Nicholas Clavin ◽  
Tomer Avraham ◽  
Valerie Longo ◽  
Babak J. Mehrara
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Acellular Dermal

Denatured acellular dermal matrix seeded with bone marrow mesenchymal stem cells for wound healing in mice

Burns ◽  
2019 ◽  
Vol 45 (7) ◽  
pp. 1685-1694 ◽  
Author(s):  
Yongjun Qi ◽  
Zhengxue Dong ◽  
Hongzhen Chu ◽  
Qi Zhao ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Marrow Mesenchymal Stem Cells ◽  
Acellular Dermal

scholarly journals Acellular dermal matrix treats lower extremity full-thickness skin defect on one-stage without skin graft or flaps

2020 ◽  
Author(s):  
Gongchi Li ◽  
Pan Zhou ◽  
Hanlin Liu ◽  
Han Peng ◽  
Binghui Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Skin Graft ◽  
Lower Extremities ◽  
Acellular Dermal Matrix ◽  
Matrix Product ◽  
Skin Defect ◽  
Full Thickness ◽  
Dermal Matrix ◽  
Acellular Dermal

Abstract Background Self-repair of lower limb wounds has always been one of the research hotspots. Flaps and skin graft are the preferred treatment for lower extremity wound reconstruction. However, these treatments have many disadvantages, such as secondary damage, poor healing quality. In recent years, the use of acellular dermal matrix has emerged as an alternative treatment option for extremity ulcers. Methods This study aimed to explore whether acellular dermal matrix can be used as a single treatment to promote wound healing. 7 patients with lower extremities cutaneous deficiency exposing bone or tendon, was covered by Pelnac, which was an acellular dermal matrix product approved by China Food and Drug Administration. All the wound was treated by Pelnac without flaps and skin graft. The external dressing was changed every 10 days. Results After a maximum of 20 weeks, all the wounds were completely healed. During the 12 months follow-up period none of the patients developed skin wear on the treatment area. All patients maintained their postoperative ambulatory ability. All patients were satisfied with the appearance and feeling after wound healing. Conclusions These findings may mean acellular dermal matrix is a novel method offering opportunity for treatment of lower extremities cutaneous deficiency exposing bone or tendon. It also has the potential to close wounds of all uninfected, non-ischemic, full-thickness cutaneous deficiency.

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