scholarly journals Unique Endothelial Gene Expression Profiles in Hyperpermeable Regions of the Porcine Aortic Arch and Thoracic Aorta

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Jeffrey A LaMack ◽  
Heather A Himburg ◽  
Morton H Friedman
Keyword(s):  
Gene Expression ◽  
Aortic Arch ◽  
Thoracic Aorta ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Endothelial Gene Expression

scholarly journals Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo

2010 ◽  
Vol 298 (1) ◽  
pp. H163-H170 ◽  
Author(s):  
Mete Civelek ◽  
Gregory R. Grant ◽  
Chrysta R. Irolla ◽  
Congzhu Shi ◽  
Rebecca J. Riley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Flow Characteristics ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Endothelial Phenotype ◽  
Regional Hemodynamics ◽  
Transcript Profiles ◽  
Endothelial Gene Expression

Atherosclerosis originates as focal arterial lesions having a predictable distribution to regions of bifurcations, branches, and inner curvatures where blood flow characteristics are complex. Distinct endothelial phenotypes correlate with regional hemodynamics. We propose that systemic risk factors modify regional endothelial phenotype to influence focal susceptibility to atherosclerosis. Transcript profiles of freshly isolated endothelial cells from three atherosusceptible and three atheroprotected arterial regions in adult swine were analyzed to determine the initial prelesional effects of hypercholesterolemia on endothelial phenotypes in vivo. Cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) was upregulated at all sites in response to short-term high-fat diet. Proinflammatory and antioxidative endothelial gene expression profiles were induced in atherosusceptible and atheroprotected regions, respectively. However, markers for endoplasmic reticulum stress, a signature of susceptible endothelial phenotype, were not further enhanced by brief hypercholesterolemia. Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia.

scholarly journals Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Gui-Hua Yue ◽  
Shao-Yuan Zhuo ◽  
Meng Xia ◽  
Zhuo Zhang ◽  
Yi-Wen Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thoracic Aorta ◽  
Group Treatment ◽  
Developmental Process ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Smooth Muscle Contraction ◽  
Control Group ◽  
Hypertensive Rats ◽  
Altered Expression

Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats.Methods. A rat model of spontaneous hypertension was used. The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChip(GC) analysis using the Agilent Whole Rat Genome Oligo Microarray.Results. Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group. Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated. GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death.Conclusion. Hypertension altered expression of many genes that regulate various biological functions. HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats. These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca(2+) homeostasis, and NO pathway. This study provides the potential novel insights into hypertension and antihypertension effects of HJD.

Mechanosensitive Endothelial Gene Expression Profiles

2006 ◽  
Vol 947 (1) ◽  
pp. 1-6 ◽  
Author(s):  
GUILLERMO GARCÍA-CARDEÑA ◽  
JASON I. COMANDER ◽  
BRETT R. BLACKMAN ◽  
KEITH R. ANDERSON ◽  
MICHAEL A. GIMBRONE
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Endothelial Gene Expression

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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