Total plasma clearance of 51Cr-EDTA: Variation with age and sex in normal adults

2000 ◽  
Vol 21 (2) ◽  
pp. 187-192 ◽  
Author(s):  
D HAMILTON ◽  
P RILEY ◽  
U MIOLA ◽  
D MOUSA ◽  
W POPOVICH ◽  
...  
Keyword(s):  
Plasma Clearance ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
51Cr Edta ◽  
Normal Adults ◽  
Age And Sex

Experimental Studies Comparing Iohexol and 51Cr-Edta for Glomerular Filtration Rate Measurements

1995 ◽  
Vol 36 (1) ◽  
pp. 58-63 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
K. Karp
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Clearance ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Experimental Studies ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
51Cr Edta

The total plasma clearance as well as the renal clearance of iohexol were evaluated for determination of the glomerular filtration rate (GFR) in 16 anesthetized pigs. The iohexol levels in urine and plasma were measured by X-ray fluorescence. The total plasma clearance of 1 and 4 ml/kg b.w. of iohexol 300 mg I/ml was compared to the simultaneously as well as nonsimultaneously calculated total plasma clearance of 51Cr-EDTA. The total plasma clearance of 51Cr-EDTA and of iohexol turned out to be equal and independent of the injected dose of iohexol. The injected dose did not have any effect on the renal clearance of iohexol either. It is concluded that iohexol and 51Cr-EDTA are similar as marker substances for determination of the GFR.

Total plasma clearance versus urinary plasma clearance of51Cr-EDTA in patients with cirrhosis with and without fluid retention

2014 ◽  
Vol 75 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Ulrik L. Henriksen ◽  
Hanne B. Hansen ◽  
Helmer Ring-Larsen ◽  
Flemming Bendtsen ◽  
Jens H. Henriksen
Keyword(s):  
Plasma Clearance ◽  
Fluid Retention ◽  
Total Plasma ◽  
Total Plasma Clearance

Simultaneous Urography and Determination of Glomerular Filtration Rate

1994 ◽  
Vol 35 (4) ◽  
pp. 391-395 ◽  
Author(s):  
S. Lundqvist ◽  
S.-O. Hietala ◽  
C. Berglund ◽  
K. Karp
Keyword(s):  
Contrast Medium ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Patient Comfort ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Sample ◽  
Fluorescence Analyzer

The total plasma clearance of iohexol at urography and 51Cr-EDTA was compared in 31 patients with di- or tetraparesis. A reference 51Cr-EDTA clearance was also performed 24 hours prior to the urography. The GFR was calculated from one, 2 or 4 plasma samples collected 180, 210, 240 and 270 min after the injection. An X-ray fluorescence analyzer was used for the analysis of iohexol in plasma as well as the contrast medium clearance calculations. It was shown that single or multiple sample clearance of iohexol and 51Cr-EDTA were equivalent methods for measurement of the GFR. The GFR was not affected by iohexol in a dose routinely used for urography. It was concluded that the patient comfort is improved if 51Cr-EDTA clearance is replaced by contrast medium clearance in association with urography.

Glomerular Filtration Rate Estimated after Multiple Injections of Contrast Medium during Angiography

1988 ◽  
Vol 29 (6) ◽  
pp. 669-674 ◽  
Author(s):  
M. Boijsen ◽  
G. Granerus ◽  
L. Jacobsson ◽  
L. Björneld ◽  
M. Aurell ◽  
...  
Keyword(s):  
Renal Failure ◽  
Contrast Medium ◽  
Filtration Rate ◽  
Plasma Clearance ◽  
Single Injection ◽  
Fluorescence Analysis ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
X Ray ◽  
Multiple Injections

In twenty-six patients referred for angiography, clearance of contrast medium was determined with x-ray fluorescence analysis after multiple injections of contrast medium. A formula for correction of the injected amount, which takes into consideration the different times of contrast medium injections, approximating the total injected amount into one injection, was used. A single injection clearance of 51Cr-EDTA was determined at the same time. The results showed a good correlation between the clearance of contrast medium after multiple injections and the 51Cr-EDTA clearance after a single injection (r=0.945). The correlation between contrast medium clearance calculated without correction for the different injection times, and “Cr-EDTA clearance was the same (r=0.946), due to short angiography time and rather low clearance values in our patients. It is concluded that total plasma clearance of contrast medium can easily be estimated after multiple injections. In this way patients with a risk of developing post-angiographic renal failure can be found.

Influence of Continuous Ambulatory Peritoneal Dialysis on Elimination of Drugs

1987 ◽  
Vol 7 (3) ◽  
pp. 159-165 ◽  
Author(s):  
John F. Maher
Keyword(s):  
Plasma Levels ◽  
Half Life ◽  
Plasma Clearance ◽  
Distribution Volume ◽  
Total Plasma ◽  
Total Plasma Clearance ◽  
Elimination Kinetics ◽  
Plasma Fraction ◽  
Dosage Guidelines ◽  
Kinetics Of

Renal failure delays elimination of many drugs thus prolonging their half lives. By knowing the half life and distribution volume, one can estimate total plasma clearance. When measured values have not been reported, endogenous total plasma clearance can be estimated and compared with peritoneal clearance to determine the effect of CAPD on half life. When peritoneal clearance has not been reported, it can be estimated knowing molecular mass and unbound plasma fraction. Such estimates suggest that elimination kinetics of most drugs are not appreciably affected by CAPD. Compared to those of untreated anuric patients, plasma levels of carbenicillin, ticarcillin, some cephalosporins, all aminoglycosides, vancomycin, sfluorocytosine, amantadine, atenolol, sotalol, timolol, chlorpropamide, theophylline and lithium may be reduced somewhat by CAPD. Thus one should monitor plasma levels of these agents to insure therapeutic concentrations rather than simply following the dosage guidelines for anuric patient.

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