Looking Forward in Geriatric Anxiety and Depression: Implications of Basic Science for the Future

2005 ◽  
Vol 13 (12) ◽  
pp. 1027-1040 ◽  
Author(s):  
Howard K. Gershenfeld ◽  
Robert A. Philibert ◽  
Gary W. Boehm
Author(s):  
Victoria Ruzhenkova ◽  
Irina Sheremet’eva ◽  
Viktor Ruzhenkov

Stress negatively affects the mental health of students, causes anxiety and depression, leads to poor academic performance, lowers level of professional training and success in the future. The purpose of the research is to study the state of mental health of medical students to develop recommendations for the prevention of maladaptation. Materials and methods. 252 5-year students aged 20–29 (22 ± 1,1) years, 168 (66,7 %) females and 84 (33,3 %) males (137 students of Belgorod State University and 115 of Altay State Medical University (ASMU)) were examined by medico-sociological and psychometric methods. Results. It was established that every fifth student of the Belgorod State University and every third of the ASMU did not enter the medical university on their own initiative. Less than half (43 %) of Belgorod State University students and 30.4 % of the ASMU ones are convinced that the choice of profession was correct, 35 and 37.4 % are, consequently, completely disappointed with it. Students of Belgorod State University dealt with training stress factors poorer and, as a result, have more pronounced mental symptoms of training stress, difficulties in organizing the daily regimen, irregular nutrition, and fear of the future. Regardless of the region of studying, the number of students not committed to the medical profession, after 5 years of study, is more than 3 times higher among those who enter the university not on their own initiative. Students of the ASMU hit substances, skipped classes, played computer games and took sedative drugs more often to overcome academic stress. The degree of anxiety before the exams in students of Belgorod State University was higher (9 points) than in their peers from the State Medical University (7 points). An extremely high (8–10 points) level of anxiety before exams was characteristic of 75,9 and 44,3 % of students, respectively. The former were more likely to experience clinically significant panic attacks: 27,7 and 6,1 %. Conclusion. Given the high incidence of social phobia (19,1–24,1 %), depression (22,6–32,2 %) and anxiety (21,9– 27,8 %) among medical students, the development and implementation of psycho-correctional programs aimed at the formation of adaptive ways to overcome stress, reduce anxiety and depression is required. This will prevent the development of psychosomatic disorders and addictions.


2021 ◽  
Author(s):  
David A. Booth

Some psychologists have viewed sadness and depression as reactions to past loss, while regarding fear and anxiety as responses to future threat. Such assumptions conflict with common experience of gloom about the future and worry about the past. Recent research on these issues by experiment and/or by questionnaire remains inconclusive. The psychometric questionnaires purport to be situation-free and the laboratory experiments use artificial tasks; hence, neither approach addresses realities in the present, past or future. In recent psychometrics, the distinction between anxiety and depression has been dissolved into one category of negative affect. One widely used inventory for separating the two emotions conflates depression with the absence of a good mood. These deficiencies were addressed in a diverse convenience sample (N = 379) by running an experiment entirely within a questionnaire. Each of the 40 question items was a miniature vignette, describing a past or future emotive situation while in bad or good mood. Five categories of situation varied in proportion of threat to loss. Strength and valence of affective response were measured by degree of autobiographical assent to or dissent from an item. This inventory provides fully affect-balanced situation-oriented depression / anxiety scaling.Effect sizes from analysis of variance showed that anxiety arises from past as well as future threats, while depression is at least as strongly oriented to losses in the future as in the past. Variation in category of situation or in valence of mood also had substantial effects. It is concluded that worry and gloom travel freely across time and situations, whether present mood is bad or good. Both laboratory experiments and psychometric scales come closer to actual processes of emotion and motivation when they revivify familiar situations using valence-balanced verbal stimuli.


2006 ◽  
Vol 21 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Shariff K. Bishai ◽  
Kevin D. Plancher

Proteomes ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 14 ◽  
Author(s):  
Emmalyn J. Dupree ◽  
Madhuri Jayathirtha ◽  
Hannah Yorkey ◽  
Marius Mihasan ◽  
Brindusa Alina Petre ◽  
...  

Proteomics is the field of study that includes the analysis of proteins, from either a basic science prospective or a clinical one. Proteins can be investigated for their abundance, variety of proteoforms due to post-translational modifications (PTMs), and their stable or transient protein–protein interactions. This can be especially beneficial in the clinical setting when studying proteins involved in different diseases and conditions. Here, we aim to describe a bottom-up proteomics workflow from sample preparation to data analysis, including all of its benefits and pitfalls. We also describe potential improvements in this type of proteomics workflow for the future.


1997 ◽  
Vol 272 (6) ◽  
pp. S36 ◽  
Author(s):  
J J Smith ◽  
S M Koethe ◽  
H V Forster

There has been increasing criticism of medical basic science teaching; much of this has focused on overcrowding of the curriculum, inadequate application to clinical medicine, and the limited commitment of the faculty to teach. We have analyzed some of the factors that may contribute to these complaints, such as the fragmentation of physiology and the conflicting roles of the medical basic scientist. We have also reviewed some previous suggestions for improving basic science teaching. We suggest that a basic scientist with a background of integrative physiology, pharmacology, anatomy, and pathology, with a special emphasis on pathophysiology, would be well qualified to assume an important role in the medical education of the future. Because there is at present no established training program of this type, we have proposed a PhD training track with this objective and have listed some of the advantages and disadvantages of such a program.


2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Maria Rita Polo Gascón ◽  
Claudio Garcia Capitão ◽  
Maria Cezira Fantini Nogueira-Martins ◽  
Jorge Casseb ◽  
Augusto Cesar Penalva Oliveira

The objective of this study was to discuss the influence of coinfection on mood states (depression and anxiety) in Human T Lymphotropic virus type 1 HTLV-1-infected patients. A cross-sectional study was performed with a sample obtained through a nonprobabilistic technique. A total of 130 patients in treatment at the HTLV Ambulatory of Instituto de Infectologia Emílio Ribas participated in the research, of whom 63 had HAM/TS and 67 were asymptomatic. A sociodemographic survey and the Beck Anxiety and Depression Inventories were used. The results indicated a prevalence of 7.2% for HTLV-1/HIV co-infection, 7.2% for HTLV-1/HCV, and 4.0% for HTLV-1/HIV/HCV. It is possible that the presence of a co-infection causes greater fear and concern about the future than asymptomatic HTLV-1 infection, increasing the observed degree of depression and anxiety.


2015 ◽  
Vol 2 (2) ◽  
pp. 24-25
Author(s):  
David Perry

Abstract Patients with haemophilia have benefited hugely from the advances in basic science achieved over the past 50 years. The introduction of clotting factor concentrates opened the door to home treatment and the subsequent availability of plasma and then recombinant products heralded the prophylaxis era. As clinicians and patients begin to manage the introduction of longer-acting factor concentrates, there are also many novel therapies and approaches in development, many of which offer the potential to transform the lives for individuals with inherited bleeding disorders and their families.


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