Intestinal Transplant Improves Quality of Life for Patients with Chronic Intestinal Failure

2017 ◽  
Vol 101 ◽  
pp. S94
Author(s):  
Lydia Holdaway ◽  
Larry Loo ◽  
Alison Smith ◽  
Lisa S. Vokes ◽  
Anil Vaidya ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intestinal Failure ◽  
Intestinal Transplant

Generic and Disease-Specific Health-Related Quality of Life in Pediatric Intestinal Failure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jessica K. McCaig ◽  
Owen S. Henry ◽  
Danielle A. Stamm ◽  
Gaby Dorval ◽  
Alexis Hurley ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intestinal Failure ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Disease Specific ◽  
Specific Health

Oral intake and plasma citrulline predict quality of life in patients with intestinal failure

Nutrition ◽  
2020 ◽  
Vol 79-80 ◽  
pp. 110855
Author(s):  
Jan Bednarsch ◽  
Elisabeth Blüthner ◽  
Mirjam Karber ◽  
Undine A. Gerlach ◽  
Andreas Pascher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intestinal Failure ◽  
Oral Intake ◽  
Plasma Citrulline

scholarly journals Nutritional Status and Quality of Life in Hospitalised Cancer Patients Who Develop Intestinal Failure and Require Parenteral Nutrition: An Observational Study

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2357
Author(s):  
Marina Plyta ◽  
Pinal S. Patel ◽  
Konstantinos C. Fragkos ◽  
Tomoko Kumagai ◽  
Shameer Mehta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Nutritional Status ◽  
Parenteral Nutrition ◽  
Cancer Patients ◽  
Screening Tool ◽  
Intestinal Failure ◽  
Normal Body Mass Index ◽  
The Impact

(1) Background: Malnutrition in cancer patients impacts quality of life (QoL) and performance status (PS). When oral/enteral nutrition is not possible and patients develop intestinal failure, parenteral nutrition (PN) is indicated. Our aim was to assess nutritional status, QoL, and PS in hospitalised cancer patients recently initiated on PN for intestinal failure. (2) Methods: The design was a cross-sectional observational study. The following information was captured: demographic, anthropometric, biochemical and medical information, as well as nutritional screening tool (NST), patient-generated subjective global assessment (PG-SGA), functional assessment of cancer therapy-general (FACT-G), and Karnofsky PS (KPS) data. (3) Results: Among 85 PN referrals, 30 oncology patients (56.2 years, 56.7% male) were identified. Mean weight (60.3 ± 16.6 kg) corresponded to normal body mass index values (21.0 ± 5.1 kg/m2). However, weight loss was significant in patients with gastrointestinal tumours (p < 0.01). A high malnutrition risk was present in 53.3–56.7% of patients, depending on the screening tool. Patients had impaired QoL (FACT-G: 26.6 ± 9.8) but PS indicated above average capability with independent daily activities (KPS: 60 ± 10). (4) Conclusions: Future research should assess the impact of impaired NS and QoL on clinical outcomes such as survival, with a view to encompassing nutritional and QoL assessment in the management pathway of this patient group.

scholarly journals N31 What factors affect quality of life and psychological well-being in patients with intestinal failure? A systematic review of quantitative studies

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S671-S671
Author(s):  
D Roberts ◽  
Q Liu ◽  
W Czuber-Dochan ◽  
P Smith ◽  
C Norton
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Failure ◽  
Factors Affecting ◽  
Positive Effects ◽  
Personal Impact ◽  
Quantitative Studies

Abstract Background The most common cause of intestinal failure (IF) is Crohn’s disease (CD). The definition of IF is ‘the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth’. It is a result of the most severe phenotype of CD, where an individual can no longer obtain sufficient nutrients and fluids from their gut to sustain life without supplementation in the form of parenteral nutrition (PN) or intravenous fluids. Home PN (HPN) allows people to receive infusion at home and increases survival rates (65% after 6 years). Whilst HPN improves length of life, studies have demonstrated this treatment can severely negatively affect an individuals’ quality of life (QoL) and employment. The aim of this systematic review was to identify factors affecting QoL in people with IF. Methods A search of databases MEDLINE, PubMed, PsycINFO, Web of Science, Global Health, and Scopus was conducted in July 2019. Search terms included ‘Crohn’s disease’, ‘short bowel syndrome’, ‘intestinal failure’, ‘quality of life’, and ‘health-related quality of life’. Titles and abstracts were screened by one reviewer. Any uncertainties about inclusion of the papers were discussed with two reviewers. Full texts were screened by 3 reviewers. Quantitative studies that measured QoL as an outcome in people with IF were included. Results Nineteen studies including a total of 924 participants met the inclusion criteria. Six key themes of factors affecting QoL were identified: (1) Practicalities of IF and HPN, e.g. sleep disturbances from the noise of the pump; managing a high output stoma. (2) Impact of medical interventions, e.g. blood tests. (3) Social impact/physical activity/personal relationships, e.g. restricted ability to travel, socialise and eat with friends. (4) Personal and sexual impact, e.g. lack of sexual desire. (5) Impact of symptoms, e.g. fatigue. (6) Patient characteristics, e.g. age. Some studies also reported positive effects on health (such as more energy), improved symptoms and QoL with HPN, especially for those who had been very unwell previously. Conclusion People with IF often have poor QoL that is affected by many factors, from their symptoms to practical aspects of HPN. However, themes related to the ‘social’ and ‘personal’ impact of IF dominated in the literature. While there is considerable evidence on what affects QoL in people with IF, there appears to very little research on attempting to improve QoL in this patient group.

Home parenteral nutrition in neuroendocrine tumour intestinal failure: improved quality of life and longevity

2020 ◽  
pp. bmjspcare-2020-002562
Author(s):  
Vandana M Sagar ◽  
Tahir Shah ◽  
Hardip Malhi ◽  
Sharmalie Parkinson ◽  
Shishir Shetty ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parenteral Nutrition ◽  
Neuroendocrine Tumour ◽  
Intestinal Failure ◽  
Case Series ◽  
Home Parenteral Nutrition ◽  
Hydration Status ◽  
Term Survival ◽  
Gastrointestinal Complications

BackgroundNeuroendocrine tumours (NETs) are neoplastic yet behave differently to typical cancers. Despite often being slow growing, they can lead to significant gastrointestinal complications including intestinal failure (IF). The use of home parenteral nutrition (HPN) in neoplastic conditions is rising, primarily for palliation and bridging through treatments for cancer, but remains a challenging decision with a paucity of high-grade evidence-based guidance.MethodsA retrospective analysis of patients with NET on HPN was performed. Data collected included the cause of IF, complications encountered with HPN and changes in nutritional assessments.ResultsEight patients were identified, all with metastatic NET. Median weight improved following HPN commencement and line sepsis was the sole complication. All patients had stabilisation and optimisation of nutritional and hydration status.ConclusionsHPN is commenced to improve or maintain patients’ nutritional status during often lifelong treatment. The principle aim in providing HPN was to improve survival and quality of life. While NETs are cancers, our case series demonstrates the potential of HPN to actively support longer term survival in the subgroup of patients who develop IF.

scholarly journals Health-Related Quality of Life in Children With Intestinal Failure

2013 ◽  
Vol 57 (3) ◽  
pp. 330-334 ◽  
Author(s):  
Sabrina E. Sanchez ◽  
Jarod P. McAteer ◽  
Adam B. Goldin ◽  
Simon Horslen ◽  
Colleen E. Huebner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intestinal Failure ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Interdisciplinary Approach to the Management of Intestinal Transplant Recipients: Evaluation, Discharge, and Lifetime Management

2005 ◽  
Vol 15 (1) ◽  
pp. 54-59
Author(s):  
Kate Samela ◽  
Erin Fennelly ◽  
Mary Brosnan ◽  
Jill Robinson
Keyword(s):  
Intestinal Failure ◽  
Interdisciplinary Approach ◽  
Open Communication ◽  
Optimal Care ◽  
Team Members ◽  
Close Relationship ◽  
Transplant Team ◽  
Intestinal Transplant

Patients suffering from intestinal failure present unique and difficult challenges to the transplant team. Augmenting the need for interdisciplinary teamwork is the higher incidence of death on the intestinal transplant waiting list. Successful management of this population requires an interdisciplinary approach at each stage of care, beginning with evaluation and continuing through discharge and lifetime management. A close relationship between patients, their caregivers, and all members of the transplant team is an essential component to successful lifetime management. Open communication between team members and unlimited accessibility to each other enables work flow to be managed efficiently, and enables the provision of optimal care. In this article, we describe the functions of the nonphysician clinical personnel needed to manage the intestinal transplant patient—beginning at the evaluation through lifetime follow-up care. The goal of each professional is the same: to restore the patient to the best quality of life possible.

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