P-38: Use of Lactase Enzyme for Control of Diarrhea in Patients Breast Fed with Short Bowel Syndrome

PURPOSE: To evaluate the biodistribution of sodium pertecnetate (Na99mTcO4) in organs and tissues, the morphometry of remnant intestinal mucosa and ponderal evolution in rats subjected to massive resection of the small intestine. METHODS: Twenty-one Wistar rats were randomly divided into three groups of 7 animals each. The short bowel (SB) group was subjected to massive resection of the small intestine; the control group (C) rats were not operated on, and soft intestinal handling was performed in sham rats. The animals were weighed weekly. On the 30th postoperative day, 0.l mL of Na99mTcO4, with mean activity of 0.66 MBq was injected intravenously into the orbital plexus. After 30 minutes, the rats were killed with an overdose of anesthetic, and fragments of the liver, spleen, pancreas, stomach, duodenum, small intestine, thyroid, lung, heart, kidney, bladder, muscle, femur and brain were harvested. The biopsies were washed with 0.9% NaCl.,The radioactivity was counted using Gama Counter WizardTM 1470, PerkinElmer. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated. Biopsies of the remaining jejunum were analysed by HE staining to obtain mucosal thickness. Analysis of variance (ANOVA) and the Tukey test for multiple comparisons were used, considering p<0.05 as significant. RESULTS: There were no significant differences in %ATI/g of the Na99mTcO4 in the organs of the groups studied (p>0.05). An increase in the weight of the SB rats was observed after the second postoperative week. The jejunal mucosal thickness of the SB rats was significantly greater than that of C and sham rats (p<0.05). CONCLUSION: In rats with experimentally-produced short bowel syndrome, an adaptive response by the intestinal mucosa reduced weight loss. The biodistribution of Na99mTcO4 was not affected by massive intestinal resection, suggesting that short bowel syndrome is not the cause of misleading interpretation, if an examination using this radiopharmaceutical is indicated.

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Energy absorption as a measure of intestinal failure in the short bowel syndrome.

Gut ◽

10.1136/gut.30.2.176 ◽

1989 ◽

Vol 30 (2) ◽

pp. 176-183 ◽

Cited By ~ 27

Author(s):

C A Rodrigues ◽

J E Lennard-Jones ◽

D G Thompson ◽

M J Farthing

Keyword(s):

Energy Absorption ◽

Short Bowel Syndrome ◽

Intestinal Failure ◽

Short Bowel

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Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract

Nutrients ◽

10.3390/nu13072325 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2325

Author(s):

Yolanda Ber ◽

Santiago García-Lopez ◽

Carla J. Gargallo-Puyuelo ◽

Fernando Gomollón

Keyword(s):

Inflammatory Bowel Disease ◽

Short Bowel Syndrome ◽

Large Intestine ◽

Malignant Tumors ◽

Short Bowel ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Macro And Micronutrients ◽

Enteral And Parenteral Nutrition ◽

Small And Large Intestine

The small intestine is key in the digestion and absorption of macro and micronutrients. The large intestine is essential for the absorption of water, to allow adequate defecation, and to harbor intestinal microbiota, for which their nutritional role is as important as it is unknown. This article will describe the causes and consequences of malnutrition in patients with inflammatory bowel diseases, the importance of screening and replacement of micronutrient deficits, and the main indications for enteral and parenteral nutrition in these patients. We will also discuss the causes of short bowel syndrome, a complex entity due to anatomical or functional loss of part of the small bowel, which can cause insufficient absorption of liquid, electrolytes, and nutrients and lead to complex management. Finally, we will review the causes, consequences, and management of malnutrition in patients with malignant and benign digestive tumors, including neuroendocrine tumors (present not only in the intestine but also in the pancreas).

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