CORR Insights®: Which Factors Are Associated with Satisfaction with Treatment Results in Patients with Hand and Wrist Conditions? A Large Cohort Analysis

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
David C. Ring
2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Willemijn Anna De Ridder ◽  
Robbert Maarten Wouters ◽  
Lisa Hoogendam ◽  
Guus Maarten Vermeulen ◽  
Harm Pieter Slijper ◽  
...  

2020 ◽  
Vol 55 (5) ◽  
pp. 1111-1115
Author(s):  
Shmuel Goldberg ◽  
Avital Stein ◽  
Elie Picard ◽  
Leon Joseph ◽  
Ron Kedem ◽  
...  

2012 ◽  
Vol 19 (4) ◽  
pp. 42-46
Author(s):  
S. Yu Berezhnoy ◽  
A. I Protsenko ◽  
V. V Kostyukov

Results of the analysis of repeated surgical interventions (34 patients, 43 feet) after previously performed surgeries for forefoot static deformities are presented. In all cases various percutaneous techniques were used. Mean follow up was 6 months (3 months — 4 years). Surgical results were assessed using patient satisfaction criterion. Satisfaction with treatment results was recorded in 95% ofpatients. It was shown that potentialities ofpercutaneous technique enabled to solve the majority offorefoot static deformityrevision surgery problems. The conclusion was made that strict order of patient management after reconstructive foot operations enabled to perform early reoperations before severe complications development.


2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 743-743
Author(s):  
Ritesh Kotecha ◽  
Erika Gedvilaite ◽  
Samuel J. Murray ◽  
Ashley Foster ◽  
Robert J. Motzer ◽  
...  

743 Background: Circulating tumor DNA (ctDNA) profiling is a non-invasive method to genomically assess solid tumors. Key benchmarks are required to assess applications in RCC management. To evaluate this tool broadly, we performed a large cohort analysis using a comparative approach to correlate clinical characteristics and matched oncogenomics of primary tumor and ctDNA. Methods: Pts with prior NGS sequenced mutational profiles from tumor (nephrectomy or metastatic tissues) underwent a single-time point plasma collection for ctDNA extraction. ctDNA targeted NGS sequencing was performed using MSK-IMPACT, with bi-directional cross genotype comparison using Waltz 2.0. Liberal (1-2 reads) and stringent (≥3 reads) filters were applied, with a cut-off of <30% allele frequency to remove germline alterations. Relevant clinical parameters were analyzed for correlation with ctDNA alteration frequency and load. Results: 110 metastatic clear-cell RCC pts, of whom available IMDC-risk was favorable (25%), intermediate (45%), or poor (4%) were included. 96% of pts had a nephrectomy prior to ctDNA collection, and most were heavily pre-treated (mean: 3 therapies, R: 0-8). The median time from diagnosis to ctDNA collection was 22.1 months (R: 2.3-215), and the median time from site specific tissue sequencing was 23.8 months (R: 1-177). 587 alterations were identified across the entire cohort in primary tissues, and 65% of pts had ≥1 alteration in ctDNA by liberal criteria. Detection rates for VHL and PBRM1 alterations were different in primary tissue and ctDNA (both liberal and stringent) with VHL altered in 92%, 43% and 50%, respectively; and PBRM1 altered in 50%, 25%, 21%, respectively. Conclusions: This large cohort analysis shows comparable mutational profiles of RCC-specific alterations in primary tissue and ctDNA, and highlights challenges of liquid biopsy approaches in RCC. Future efforts to correlate clinical outcomes with algorithm-based metrics will enhance the utility of this tool.[Table: see text]


2015 ◽  
Vol 148 (4) ◽  
pp. S-250-S-251 ◽  
Author(s):  
Anthony de Buck van Overstraeten ◽  
Emma J. Eshuis ◽  
Severine Vermeire ◽  
Gert A. Van Assche ◽  
Marc Ferrante ◽  
...  

2022 ◽  
Author(s):  
Shmuel Goldberg ◽  
Elie Picard ◽  
Leon Joseph ◽  
Ron Kedem ◽  
Adir Sommer ◽  
...  

2020 ◽  
Vol 123 ◽  
pp. 104255 ◽  
Author(s):  
Lucia Taramasso ◽  
Laura Magnasco ◽  
Bianca Bruzzone ◽  
Patrizia Caligiuri ◽  
Giorgio Bozzi ◽  
...  

2020 ◽  
Vol 158 (6) ◽  
pp. S-1594
Author(s):  
Pedro Palacios Argueta ◽  
Miguel Salazar ◽  
A. Sebastian Simons-Linares ◽  
John J. Vargo ◽  
Prabhleen Chahal ◽  
...  

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