Evaluating Visual Field Progression in Advanced Glaucoma Using Trend Analysis of Targeted Mean Total Deviation

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Atsuya Miki ◽  
Tomoyuki Okazaki ◽  
Robert N. Weinreb ◽  
Misa Morota ◽  
Aki Tanimura ◽  
...  
Keyword(s):  
Visual Field ◽  
Trend Analysis ◽  
Visual Field Progression ◽  
Total Deviation ◽  
Advanced Glaucoma

scholarly journals Classification and Statistical Trend Analysis in Detecting Glaucomatous Visual Field Progression

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Cristiana Valente ◽  
Elisa D’Alessandro ◽  
Michele Iester
Keyword(s):  
Statistical Analysis ◽  
Standard Deviation ◽  
Visual Field ◽  
Trend Analysis ◽  
Open Angle Glaucoma ◽  
Mean Deviation ◽  
Threshold Strategy ◽  
Visual Field Progression ◽  
The Mean

Aim. To evaluate the agreement between different methods in detection of glaucomatous visual field progression using two classification-based methods and four statistical approaches based on trend analysis. Methods. This is a retrospective and longitudinal study. Twenty Caucasian patients (mean age 73.8 ± 13.43 years) with open-angle glaucoma were recruited in the study. Each visual field was assessed by Humphrey Field Analyzer, program SITA standard 30-2 or 24-2 (Carl Zeiss Meditec, Inc., Dublin, CA). Full threshold strategy was also accepted for baseline tests. Progression was analyzed by using Hodapp–Parrish–Anderson classification and the Advanced Glaucoma Intervention Study visual field defect score. For the statistical analysis, linear regression (r2) was calculated for mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI), and when it was significant, each series of visual field was considered progressive. We also used Progressor to look for a significant progression of each visual field series. The agreement between methods, based on statistical analysis and classification, was evaluated using a weighted kappa statistic. Results. Thirty-eight visual field series were analyzed. The mean follow-up time was 6.2 ± 1.53 years (mean ± standard deviation). At baseline, the mean MD was −7.34 ± 7.18 dB; at the end of the follow-up, the mean MD was −9.25 ± 8.65 dB; this difference was statistically significant (p<0.001). The agreement to detect progression was fair between all methods based on statistical analysis and classification except for PSD r2. A substantial agreement (κ = 0.698 ± 0.126) was found between MD r2 and VFI r2. With the use of all the statistical analysis, there was a better time-saving. Conclusions. The best agreement to detect progression was found between MD r2 and VFI r2. VFI r2 showed the best agreement with all the other methods. GPA2 can help ophthalmologists to detect glaucoma progression and to help in treatment decisions. PSD r2 was the worse method to detect progression.

Validating the efficacy of the binomial pointwise linear regression method to detect glaucoma progression with multicentral database

2019 ◽  
Vol 104 (4) ◽  
pp. 569-574
Author(s):  
Shotaro Asano ◽  
Hiroshi Murata ◽  
Masato Matsuura ◽  
Yuri Fujino ◽  
Atsuya Miki ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Trend Analysis ◽  
Predictive Value ◽  
False Positive Rate ◽  
Linear Regression Method ◽  
Trend Analyses ◽  
Total Deviation ◽  
Positive Rate ◽  
Test Points

Background/aimWe previously reported the benefit of applying binomial pointwise linear regression (PLR: binomial PLR) to detect 10–2 glaucomatous visual field (VF) progression. The purpose of the current study was to validate the usefulness of the binomial PLR to detect glaucomatous VF progression in the central 24°.MethodsSeries of 15 VFs (Humphrey Field Analyzer 24–2 SITA-standard) from 341 eyes of 233 patients, obtained over 7.9±2.1 years (mean±SD), were investigated. PLR was performed by regressing the total deviation of all test points. VF progression was determined from the VF test points analyses using the binomial test (one side, p<0.025). The time needed to detect VF progression was compared across the binomial PLR, permutation analysis of PLR (PoPLR) and mean total deviation (mTD) trend analysis.ResultsThe binomial PLR was comparable with PoPLR and mTD trend analyses in the positive predictive value (0.18–0.87), the negative predictive value (0.89–0.95) and the false positive rate (0.057–0.35) to evaluate glaucomatous VF progression. The time to classify progression with binomial PLR (5.8±2.8 years) was significantly shorter than those with mTD trend analysis (6.7±2.8 years) and PoPLR (6.6±2.7 years).ConclusionsThe binomial PLR method, which detected glaucomatous VF progression in the central 24° significantly earlier than PoPLR and mTD trend analyses, shows promise for improving our ability to detect visual field progression for clinical management of glaucoma and in clinical trials of new glaucoma therapies.

Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma

2017 ◽  
Vol 101 (12) ◽  
pp. 1658-1665 ◽  
Author(s):  
Shuichiro Aoki ◽  
Hiroshi Murata ◽  
Yuri Fujino ◽  
Masato Matsuura ◽  
Atsuya Miki ◽  
...  
Keyword(s):  
Visual Field ◽  
Trend Analysis ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Visual Field Progression

Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

2021 ◽  
Author(s):  
Kouros Nouri-Mahdavi ◽  
Vahid Mohammadzadeh ◽  
Alessandro Rabiolo ◽  
Kiumars Edalati ◽  
Joseph Caprioli ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Field Progression ◽  
Structural Measures ◽  
Advanced Glaucoma

Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study

Ophthalmology ◽  
2004 ◽  
Vol 111 (9) ◽  
pp. 1627-1635 ◽  
Author(s):  
Kouros Nouri-Mahdavi ◽  
Douglas Hoffman ◽  
Anne L. Coleman ◽  
Gang Liu ◽  
Gang Li ◽  
...  
Keyword(s):  
Visual Field ◽  
Predictive Factors ◽  
Intervention Study ◽  
Visual Field Progression ◽  
Advanced Glaucoma

scholarly journals Slowed Saccadic Reaction Times in Seemingly Normal Parts of Glaucomatous Visual Fields

2021 ◽  
Vol 8 ◽  
Author(s):  
Gijs Thepass ◽  
Hans G. Lemij ◽  
Koenraad A. Vermeer ◽  
Johannes van der Steen ◽  
Johan J. M. Pel
Keyword(s):  
Visual Field ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Generalized Linear Mixed Model ◽  
Healthy Controls ◽  
Total Deviation ◽  
Sensitivity Loss ◽  
Field Sensitivity ◽  
Advanced Glaucoma ◽  
Eye Movement Perimetry

Purpose: In eye movement perimetry, peripheral stimuli are confirmed by goal-directed eye movements toward the stimulus. The saccadic reaction time (SRT) is regarded as an index of visual field responsiveness, whereas in standard automated perimetry (SAP), the visual field sensitivity is tested. We investigated the relation between visual field sensitivity and responsiveness in corresponding locations of the visual field in healthy controls and in patients with mild, moderate and advanced glaucoma.Materials and Methods: Thirty-four healthy control subjects and 42 glaucoma patients underwent a 54-point protocol in eye movement perimetry (EMP) and a 24-2 SITA standard protocol in a Humphrey Field Analyzer. The visual field points were stratified by total deviation sensitivity loss in SAP into 6 strata. A generalized linear mixed model was applied to determine the influence of the various factors.Results: The generalized linear mixed model showed that the mean SRT increased with increasing glaucoma severity, from 479 ms in the control eyes to 678 ms in the eyes of patients with advanced glaucoma (p &lt; 0.001). Mean SRTs significantly increased with increasing SAP sensitivity loss. Even at the locations where no sensitivity loss was detected by SAP (total deviation values greater or equal than 0 dB), we found lengthened SRTs in mild, moderate and advanced glaucoma compared to healthy controls (p &lt; 0.05) and in moderate and advanced glaucoma compared to mild glaucoma (p &lt; 0.05). At locations with total deviation values between 0 and −3 dB, −3 and −6 dB and −6 and −12 dB, we found similar differences.Conclusions: The lengthened SRT in areas with normal retinal sensitivities in glaucomatous eyes, i.e., planning and execution of saccades to specific locations, precede altered sensory perception as assessed with SAP. Better understanding of altered sensory processing in glaucoma might allow earlier diagnosis of emerging glaucoma.

Sign in / Sign up

Export Citation Format

Share Document