Editorial: Endocrine disorders and body composition during childhood and adolescence

2022 ◽  
Vol 29 (1) ◽  
pp. 34-35
Author(s):  
Lynne L. Levitsky
Keyword(s):  
Body Composition ◽  
Endocrine Disorders ◽  
Childhood And Adolescence

scholarly journals Targeted Gene Sequencing, Bone Health, and Body Composition in Cornelia de Lange Syndrome

2021 ◽  
Vol 11 (2) ◽  
pp. 710
Author(s):  
Ángel Matute-Llorente ◽  
Ángela Ascaso ◽  
Ana Latorre-Pellicer ◽  
Beatriz Puisac ◽  
Laura Trujillano ◽  
...  
Keyword(s):  
Body Composition ◽  
Lean Mass ◽  
Bone Health ◽  
Cornelia De Lange Syndrome ◽  
Areal Bone Mineral Density ◽  
Childhood And Adolescence ◽  
Mineral Density ◽  
Calcium Phosphorus ◽  
Cornelia De Lange ◽  
Targeted Gene Sequencing

The aim of this study was to evaluate bone health and body composition by dual-energy X-ray absorptiometry (DXA) in individuals with Cornelia de Lange Syndrome (CdLS). Overall, nine individuals with CdLS (five females, all Caucasian, aged 5–38 years) were assessed. Total body less head (TBLH) and lumbar spine (LS) scans were performed, and bone serum biomarkers were determined. Molecular analyses were carried out and clinical scores and skeletal features were assessed. Based on deep sequencing of a custom target gene panel, it was discovered that eight of the nine CdLS patients had potentially causative genetic variants in NIPBL. Fat and lean mass indices (FMI and LMI) were 3.4–11.1 and 8.4–17.0 kg/m2, respectively. For TBLH areal bone mineral density (aBMD), after adjusting for height for age Z-score of children and adolescents, two individuals (an adolescent and an adult) had low BMD (aBMD Z-scores less than –2.0 SD). Calcium, phosphorus, 25-OH-vitamin D, parathyroid hormone, and alkaline phosphatase levels were 2.08–2.49 nmol/L, 2.10–3.75 nmol/L, 39.94–78.37 nmol/L, 23.4–80.3 pg/mL, and 43–203 IU/L, respectively. Individuals with CdLS might have normal adiposity and low levels of lean mass measured with DXA. Bone health in this population seems to be less of a concern during childhood and adolescence. However, they might be at risk for impaired bone health due to low aBMD in adulthood.

scholarly journals Body composition in childhood: effects of normal growth and disease

2003 ◽  
Vol 62 (2) ◽  
pp. 521-528 ◽  
Author(s):  
J. C. K. Wells
Keyword(s):  
Body Composition ◽  
Childhood Obesity ◽  
Fat Mass ◽  
Lean Mass ◽  
Normal Weight ◽  
Fat Free Mass ◽  
General Interest ◽  
Childhood And Adolescence ◽  
Adult Disease ◽  
Increased Risk

Body composition in children is of increasing interest within the contexts of childhood obesity, clinical management of patients and nutritional programming as a pathway to adult disease. Energy imbalance appears to be common in many disease states; however, body composition is not routinely measured in patients. Traditionally, clinical interest has focused on growth or nutritional status, whereas more recent studies have quantified fat mass and lean mass. The human body changes in proportions and chemical composition during childhood and adolescence. Most of the weight gain comprises lean mass rather than fat. In general, interest has focused on percentage fat, and less attention has been paid to the way in which lean mass varies within and between individuals. In the general population secular trends in BMI have been widely reported, indicating increasing levels of childhood obesity, which have been linked to reduced physical activity. However, lower activity levels may potentially lead not only to increased fatness, but also to reduced lean mass. This issue merits further investigation. Diseases have multiple effects on body composition and may influence fat-free mass and/or fat mass. In some diseases both components change in the same direction, whereas in other diseases, the changes are contradictory and may be concealed by relatively normal weight. Improved techniques are required for clinical evaluations. Both higher fatness and reduced lean mass may represent pathways to an increased risk of adult disease.

scholarly journals Body Composition During Childhood and Adolescence: Relations to Bone Strength and Microstructure

2014 ◽  
Vol 99 (12) ◽  
pp. 4641-4648 ◽  
Author(s):  
Joshua N. Farr ◽  
Shreyasee Amin ◽  
Nathan K. LeBrasseur ◽  
Elizabeth J. Atkinson ◽  
Sara J. Achenbach ◽  
...  
Keyword(s):  
Body Composition ◽  
Bone Strength ◽  
Childhood And Adolescence

scholarly journals Accounting for height in indices of body composition during childhood and adolescence

2019 ◽  
Vol 4 ◽  
pp. 105 ◽  
Author(s):  
Linda M. O'Keeffe ◽  
Abigail Fraser ◽  
Laura D. Howe
Keyword(s):  
Body Composition ◽  
Cohort Study ◽  
Body Mass ◽  
Fat Mass ◽  
Early Life ◽  
Fat Free Mass ◽  
Childhood And Adolescence ◽  
Total Body Mass ◽  
Total Body ◽  
Age And Sex

Correlations of body composition with height vary by age and sex during childhood. Standard approaches to accounting for height in measures of body composition (dividing by height (in meters)2) do not take this into account. Using measures of total body mass (TBM), fat mass (FM) and fat free mass (FFM) at ages nine, 11, 13, 15 and 18 years from a longitudinal UK cohort study (ALSPAC), we calculated indices of body composition at each age by dividing measures by height (in meters)2. We then produced age-and sex-specific powers of height using allometric regressions and calculated body composition indices by dividing measures by height raised to these powers. TBM, FM and FFM divided by height2 were correlated with height up-to age 11 in females. In males, TBM and FM divided by height2 were correlated with height up-to age 15 years while FM divided by height2 was correlated with height up-to age 11 years. Indices of body composition using age-and sex-specific powers were not correlated with height at any age. In early life, age-and sex-specific powers of height, rather than height in meters2, should be used to adjust body composition for height when measures of adiposity/mass independent of height are required.

scholarly journals Indicators to Assess Physical Health of Children and Adolescents in Activity Research—A Scoping Review

2021 ◽  
Vol 18 (20) ◽  
pp. 10711
Author(s):  
Simon Kolb ◽  
Alexander Burchartz ◽  
Doris Oriwol ◽  
Steffen C. E. Schmidt ◽  
Alexander Woll ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Physical Health ◽  
Children And Adolescents ◽  
Sedentary Behavior ◽  
Scoping Review ◽  
Health Indicators ◽  
Later Life ◽  
Future Research ◽  
Childhood And Adolescence

Sufficient physical activity can help promote and maintain health, while its lack can jeopardize it. Since health and physical activity lay their foundation for later life in childhood and adolescence, it is important to examine this relationship from the beginning. Therefore, this scoping review aims to provide an overview of physical health indicators in children and adolescents in research on the effects of physical activity and sedentary behavior. We identified the indicators used to quantify or assess physical health and summarized the methods used to measure these indicators. We systematically searched Scopus, Pubmed, and Web of Science databases for systematic reviews. The search yielded 4595 records from which 32 records were included in the review. The measurements for physical health reported in the reviews contained measures of body composition, cardiometabolic biomarkers, physical fitness, harm/injury, or bone health. Body composition was the most used indicator to assess and evaluate physical health in children, whereas information on harm and injury was barely available. In future research longitudinal studies are mandatory to focus on the prospective relationships between physical activity or sedentary behavior, and physical health.

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