scholarly journals Gut Microbiota Composition of Biliary Atresia Patients Prior to Kasai Portoenterostomy Associates With Long-Term Outcome

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Daan B.E. van Wessel ◽  
M. Nomden ◽  
J.L.M. Bruggink ◽  
R.H.J. de Kleine ◽  
A. Kurilshikov ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Biliary Atresia ◽  
Microbiota Composition ◽  
Kasai Portoenterostomy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Gut Microbiota Composition

scholarly journals Antibiotics at birth and later antibiotic courses: effects on gut microbiota

2021 ◽  
Author(s):  
Sofia Ainonen ◽  
Mysore V Tejesvi ◽  
Md. Rayhan Mahmud ◽  
Niko Paalanne ◽  
Tytti Pokka ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Control Group ◽  
List Type ◽  
Antibiotic Exposure ◽  
Microbiota Composition ◽  
Long Term Effects ◽  
The Impact ◽  
Antibiotic Courses ◽  
Gut Microbiota Composition

Abstract Background Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of the long-term effects on the gut microbiota and subsequent health of children is limited. Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. Methods This was a prospective, controlled cohort study among 100 vaginally delivered infants with different perinatal antibiotic exposures: control (27), IAP (27), postnatal antibiotics (24), and IAP and postnatal antibiotics (22). At 1 year of age, we performed next-generation sequencing of the bacterial 16S ribosomal RNA gene of fecal samples. Results Exposure to the perinatal antibiotics had a clear impact on the gut microbiota. The abundance of the Bacteroidetes phylum was significantly higher in the control group, whereas the relative abundance of Escherichia coli was significantly lower in the control group. The impact of the perinatal antibiotics on the gut microbiota composition was greater than exposure to later courses of antibiotics (28% of participants). Conclusions Perinatal antibiotic exposure had a marked impact on the gut microbiota at the age of 1 year. The timing of the antibiotic exposure appears to be the critical factor for the changes observed in the gut microbiota. Impact Infants are commonly exposed to IAP and postnatal antibiotics, and later to courses of antibiotics during the first year of life. Perinatal antibiotics have been associated with an altered gut microbiota during the first months of life, whereas the evidence regarding the long-term impact is more limited. Perinatal antibiotic exposure had a marked impact on the infant’s gut microbiota at 1 year of age. Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of antibiotics at the age of 1 year.

scholarly journals Publisher Correction: Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

Nature ◽  
2018 ◽  
Vol 563 (7731) ◽  
pp. E25-E25
Author(s):  
Marcus Fulde ◽  
Felix Sommer ◽  
Benoit Chassaing ◽  
Kira van Vorst ◽  
Aline Dupont ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Microbiota Composition ◽  
Toll Like Receptor ◽  
Toll Like Receptor 5 ◽  
Gut Microbiota Composition

Long-term outcome and necessity of liver transplantation in infants with biliary atresia are independent of cytokine milieu in native liver and serum

Cytokine ◽  
2018 ◽  
Vol 111 ◽  
pp. 382-388 ◽  
Author(s):  
Omid Madadi-Sanjani ◽  
Joachim F. Kuebler ◽  
Stephanie Dippel ◽  
Anna Gigina ◽  
Christine S. Falk ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Biliary Atresia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Native Liver ◽  
Cytokine Milieu

Significance and indications for reoperative portoenterostomy in biliary atresia in light of long-term outcome

2018 ◽  
Vol 25 (5) ◽  
pp. 275-280
Author(s):  
Takeshi Saito ◽  
Keita Terui ◽  
Tetsuya Mitsunaga ◽  
Mitsuyuki Nakata ◽  
Shugo Komatsu ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Is It Time to Use Probiotics to Prevent or Treat Obesity?

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1613 ◽  
Author(s):  
Andrea Brusaferro ◽  
Rita Cozzali ◽  
Ciriana Orabona ◽  
Anna Biscarini ◽  
Edoardo Farinelli ◽  
...  
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
Overweight And Obesity ◽  
Microbiota Composition ◽  
Long Term Effects ◽  
Obesity Control ◽  
Treatment Of Obesity ◽  
Faecal Bacteria ◽  
Gut Microbiota Composition

In recent years, attention has been given to the role potentially played by gut microbiota in the development of obesity. Several studies have shown that in individuals with obesity, the gut microbiota composition can be significantly different from that of lean individuals, that faecal bacteria can exert a fundamental role in modulating energy metabolism, and that modifications of gut microbiota composition can be associated with increases or reductions of body weight and body mass index. Based on this evidence, manipulation of the gut microbiota with probiotics has been considered a possible method to prevent and treat obesity. However, despite a great amount of data, the use of probiotics to prevent and treat obesity and related problems remains debated. Studies have found that the probiotic effect on body weight and metabolism is strain specific and that only some of the species included in the Lactobacillus and Bifidobacterium genera are effective, whereas the use of other strains can be deleterious. However, the dosage, duration of administration, and long-term effects of probiotics administration to prevent overweight and obesity are not known. Further studies are needed before probiotics can be rationally prescribed for the prevention or treatment of obesity. Control of the diet and environmental and life-style factors that favour obesity development remain the best solution to problems related to weight gain.

scholarly journals Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations

2019 ◽  
Vol 59 (5) ◽  
pp. 1845-1858 ◽  
Author(s):  
Angela Genoni ◽  
Claus T. Christophersen ◽  
Johnny Lo ◽  
Megan Coghlan ◽  
Mary C. Boyce ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Resistant Starch ◽  
Microbiota Composition ◽  
Paleolithic Diet ◽  
Gut Microbiota Composition
Sign in / Sign up

Export Citation Format

Share Document