scholarly journals Comparison of the Clinicopathologic Features and T-Cell Infiltration of B7-H3 and B7-H4 Expression in Triple-negative Breast Cancer Subtypes

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nah Ihm Kim ◽  
Min Ho Park ◽  
NamKi Cho ◽  
Ji Shin Lee
2021 ◽  
Vol 85 ◽  
pp. 104664
Author(s):  
Mohan Li ◽  
Kexin Zheng ◽  
Shiliang Ma ◽  
Pengpeng Hu ◽  
Bo Yuan ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 765
Author(s):  
Florence Boissière-Michot ◽  
Ghita Chabab ◽  
Caroline Mollevi ◽  
Séverine Guiu ◽  
Evelyne Lopez-Crapez ◽  
...  

The prognostic impact of the different tumor-infiltrating lymphocyte (TIL) subpopulations in solid cancers is still debated. Here, we investigated the clinicopathological correlates and prognostic impact of TILs, particularly of γδ T cells, in 162 patients with triple-negative breast cancer (TNBC). A high γδ T cell density (>6.625 γδ T cells/mm2) was associated with younger age (p = 0.008), higher tumor histological grade (p = 0.002), adjuvant chemotherapy (p = 0.010), BRCA1 promoter methylation (p = 0.010), TIL density (p < 0.001), and PD-L1 (p < 0.001) and PD-1 expression (p = 0.040). In multivariate analyses, γδ T cell infiltration (cutoff = 6.625 γδ T cells/mm2) was an independent prognostic factor (5-year relapse-free survival: 63.3% vs. 89.8%, p = 0.027; 5-year overall survival: 73.8% vs. 89.9%, p = 0.031, for low vs. high infiltration). This prognostic impact varied according to the tumor PIK3CA mutational status. High γδ T cell infiltration was associated with better survival in patients with PIK3CA wild-type tumors, but the difference was not significant in the subgroup with PIK3CA-mutated tumors. Altogether, these data suggest that high γδ T cell infiltrate is correlated with immune infiltration and might represent a candidate prognostic tool in patients with TNBC.


Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
AJ Robles ◽  
L Du ◽  
S Cai ◽  
RH Cichewicz ◽  
SL Mooberry

2011 ◽  
Vol 121 (7) ◽  
pp. 2750-2767 ◽  
Author(s):  
Brian D. Lehmann ◽  
Joshua A. Bauer ◽  
Xi Chen ◽  
Melinda E. Sanders ◽  
A. Bapsi Chakravarthy ◽  
...  

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
AJ Robles ◽  
S Cai ◽  
L Du ◽  
CV Shaffer ◽  
T Grkovic ◽  
...  

2013 ◽  
Author(s):  
Jeanne Kowalski ◽  
Jeffery M. Switchenko ◽  
Bhakti Dwivedi ◽  
Dana Nickleach ◽  
Carlos S. Moreno

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