Release of Matrix Metalloproteinases by Macrophages in Radicular Cysts and Residual Radicular Cysts

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Glória M. França ◽  
Cristianne K.S. Medeiros ◽  
Dennys R.M.F. Almeida ◽  
Juliana C. Pinheiro ◽  
Ana L.D.L. de Andrade ◽  
...  
2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.


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