Cushing Syndrome Secondary to Ectopic Adrenocorticotropic Hormone Secretion From Recurrent Olfactory Neuroblastoma

2007 ◽  
Vol 17 (3) ◽  
pp. 160-161
Author(s):  
Muhammad Imran Butt ◽  
S A. Olczak
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Cushing Syndrome ◽  
Hormone Secretion ◽  
Olfactory Neuroblastoma ◽  
Ectopic Adrenocorticotropic Hormone

scholarly journals Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion

Cancer ◽  
2011 ◽  
Vol 117 (19) ◽  
pp. 4381-4389 ◽  
Author(s):  
Shamim Ejaz ◽  
Rena Vassilopoulou-Sellin ◽  
Naifa L. Busaidy ◽  
Mimi I. Hu ◽  
Steven G. Waguespack ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Cushing Syndrome ◽  
Hormone Secretion ◽  
Ectopic Adrenocorticotropic Hormone

Cushing syndrome: a rare presentation of bronchial carcinoid tumor

2019 ◽  
Vol 27 (7) ◽  
pp. 603-605
Author(s):  
Pavneet Kohli ◽  
Prasanth Penumadu ◽  
K Chandrashekhar Rao ◽  
Sreevathsa KS Prasad ◽  
Sadishkumar Kamalanathan
Keyword(s):  
Carcinoid Tumor ◽  
Adrenocorticotropic Hormone ◽  
Cushing Syndrome ◽  
Imaging Techniques ◽  
Hormone Secretion ◽  
Clinical Feature ◽  
Bronchial Carcinoid ◽  
Rare Presentation ◽  
Pulmonary Carcinoid ◽  
Ectopic Adrenocorticotropic Hormone

Cushing syndrome is a very rare clinical feature of typical pulmonary carcinoid, caused by hypercorticism, and despite advances in imaging techniques, it poses a difficult diagnostic and therapeutic challenge. We report the case of a patient presenting with Cushing syndrome associated with ectopic adrenocorticotropic hormone secretion from a bronchial carcinoid, whose management presented diagnostic and therapeutic challenges.

Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child

2011 ◽  
Vol 24 (3-4) ◽  
Author(s):  
Patrizia Matarazzo ◽  
Gerdi Tuli ◽  
Daniele Tessaris ◽  
Francesca Verna ◽  
Ivana Rabbone ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Cushing Syndrome ◽  
Hormone Secretion ◽  
Ectopic Adrenocorticotropic Hormone

scholarly journals Median 10 years follow-up of patients with covert Cushing’s syndrome: a case series

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Farzad Najafipour ◽  
Amir Bahrami ◽  
Mitra Niafar ◽  
Jalil Houshyar ◽  
Monireh Halimi ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Adrenocorticotropic Hormone ◽  
Hormone Secretion ◽  
Cushing's Syndrome ◽  
Whole Body ◽  
Whole Body Scan ◽  
Body Scan ◽  
Posterior Aspect ◽  
Ectopic Adrenocorticotropic Hormone

Abstract Background Ectopic adrenocorticotropic hormone secretion syndrome occurs in 10% of all patients with adrenocorticotropic-hormone-dependent hypercortisolism. It is usually associated with overt malignancies or with occult and indolent tumors. This study aims to confirm the source of ectopic adrenocorticotropic hormone in four patients with ectopic Cushing’s syndrome over time. Case presentation A 38-year-old Iranian man with Cushing’s syndrome underwent bilateral adrenalectomy since the source of ectopic adrenocorticotropic hormone secretion was not localized and pituitary imaging was normal. A whole-body scan revealed a right-lung tumoral mass with mediastinal lymph node metastasis. The mass was assumed a lung carcinoid tumor with mediastinal adenopathy. Right-lung mid-zone lobectomy and mediastinal lymphadenectomy were done. In a 47-year-old Iranian man with Cushing’s syndrome, whole-body computed tomography scan revealed a pulmonary nodule in the posterior segment of the left lower lobe of the lung. The third case was a 25-year-old Iranian man who presented with symptoms and signs of Cushing’s syndrome. Pituitary magnetic resonance imaging revealed a microadenoma 5 × 9 mm. Whole-body scan showed abnormal focal somatostatin receptors analog avid lesion in the posterior aspect of inferior third of right lung, highly suggestive of ectopic adrenocorticotropic-hormone-producing tumor. The last case was a 43-year-old Iranian woman with Marfan syndrome with a history of mitral and aortic valve replacement and chronic dissection of the aorta, who presented with symptoms and signs of Cushing’s syndrome. She underwent bilateral adrenalectomy 1 year later owing to failure to locate ectopic adrenocorticotropic hormone syndrome. Whole-body scan showed abnormally increased radiotracer uptake in the midline of the skull base and posterior aspect of the middle zone of left hemithorax and bed of left lobe of thyroid. Conclusion The clinical spectrum of ectopic adrenocorticotropic hormone secretion syndrome is wide, and distinguishing Cushing’s disease from ectopic adrenocorticotropic hormone secretion syndrome is difficult. Initial failure to identify a tumor is common. Pulmonary carcinoid or occult source of ectopic adrenocorticotropic hormone secretion syndrome is usually the cause. In occult cases of ectopic adrenocorticotropic hormone in which the tumor cannot be localized, serial follow-up with serial computed tomography, magnetic resonance imaging, or scintigraphy is recommended for several years until the tumor can be localized and treated.

scholarly journals An Unusual Cause of Severe Immunosuppression

2015 ◽  
Vol 10 (3) ◽  
Author(s):  
Karan Bami MD ◽  
Winnie Chan MD ◽  
Oren Steen MD ◽  
Ally PH Prebtani MD ◽  
Nishma Singhal MD
Keyword(s):  
Diabetes Mellitus ◽  
Adrenocorticotropic Hormone ◽  
Opportunistic Infections ◽  
Clinical Status ◽  
Hormone Secretion ◽  
Unknown Origin ◽  
Rapid Onset ◽  
Bk Virus ◽  
Bilateral Adrenalectomy ◽  
Ectopic Adrenocorticotropic Hormone

Ectopic adrenocorticotropic hormone secretion (EAS) is a rare cause of endogenous Cushing’s syndrome and is associated with immunosuppression and opportunistic infections. We report the case of a person who presented with rapid onset of hypertension, diabetes mellitus, and severe hypokalemia in the context of significantly elevated adrenocorticotropic hormone (ACTH) levels and marked hypercortisolism. Subsequent investigations led to a diagnosis of EAS without an identifiable source. Her clinical status continued to deteriorate despite medical management of her hypercortisolemia, thus an urgent bilateral adrenalectomy was performed. This patient’s course was complicated by multiple opportunistic infections with cytomegalovirus, Pneumocystis jirovecii (PJP), Mycobacterium tuberculosis and possibly BK virus. To the best of our knowledge, this is the first description of this specific constellation of opportunistic infections in the setting of EAS. Our case highlights the need to consider multiple and rare opportunistic infections while managing EAS and supports early bilateral adrenalectomy in critically ill patients with EAS of unknown origin.

Metyrapone for Delirium Due to Cushing's Syndrome Induced by Occult Ectopic Adrenocorticotropic Hormone Secretion

2004 ◽  
Vol 65 (7) ◽  
pp. 1019-1020 ◽  
Author(s):  
Toshiro Kawashima ◽  
Mariko Oda ◽  
Taisuke Kuno ◽  
Hiroshi Ueki ◽  
Shigeto Yamada ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Adrenocorticotropic Hormone ◽  
Hormone Secretion ◽  
Cushing's Syndrome ◽  
Ectopic Adrenocorticotropic Hormone
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