scholarly journals Determinants of Immune Response to Anti–SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Maria Magicova ◽  
Ivan Zahradka ◽  
Martina Fialova ◽  
Tomas Neskudla ◽  
Jiri Gurka ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Low rate of COVID‐19 pneumonia in kidney transplant recipients—A battle between infection and immune response?

2020 ◽  
Vol 22 (5) ◽  
Author(s):  
Maryam Ghaffari Rahbar ◽  
Mohsen Nafar ◽  
Alireza Khoshdel ◽  
Nooshin Dalili ◽  
Alireza Abrishami ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Low Rate

scholarly journals Immune Response Post-SARS-CoV-2 mRNA Vaccination in Kidney-Transplant Recipients Receiving Belatacept

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Johan Noble ◽  
Antoine Langello ◽  
William Bouchut ◽  
Julien Lupo ◽  
Dorothee Lombardo ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Response Post

Evaluation of Cell-mediated Immune Response by QuantiFERON Monitor® Assay in Kidney Transplant Recipients

2018 ◽  
Vol 102 ◽  
pp. S130
Author(s):  
Ivan Margeta ◽  
Ivana Mareković ◽  
Ana Pešut ◽  
Marina Zelenika ◽  
Marija Dorotić ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cell Mediated Immune Response

scholarly journals Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients

2021 ◽  
Vol 10 (21) ◽  
pp. 4833
Author(s):  
Dorota Kamińska ◽  
Hanna Augustyniak-Bartosik ◽  
Katarzyna Kościelska-Kasprzak ◽  
Marcelina Żabińska ◽  
Dorota Bartoszek ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Kidney Transplant ◽  
Adaptive Immunity ◽  
Cell Response ◽  
Cellular Response ◽  
T Cell Response ◽  
Interferon Gamma Release Assay ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Background. It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR. Methods. The study included 26 HD patients and 54 KTR—both convalescent (14 HD, 25 KTR) and unexposed. The immune response was assessed by determining the anti-SARS-CoV-2 antibodies in serum and specific T cell response via the interferon-gamma release assay (IGRA). Moreover, blood-morphology-derived parameters, immune cell phenotypes, and acute phase reactants were evaluated. Results. KRT and HD convalescents presented similar serum levels of anti-SARS-CoV-2 IgG and IgA. A negative correlation occurred between IgG and time after the infection was observed. There was a strong relationship between the prevalence of anti-SARS-CoV-2 cellular and humoral responses in both groups. Convalescent IGRA response was significantly higher in HD patients compared to KTR. Conclusions. HD patients and KTR develop humoral and cellular responses after COVID-19. The antibodies levels are similar in both groups of patients. SARS-CoV-2-reactive T cell response is stronger in HD patients compared to KTR. The SARS-CoV-2-specific IgG level decreases with time while IgA and a cellular response are maintained. IGRA proved to be a valuable test for the assessment of specific cellular immunity in immunocompromised HD patients and KTR.

Sign in / Sign up

Export Citation Format

Share Document