scholarly journals A lack of repeatability creates the illusion of a trade-off between basal and plastic cold tolerance

2021 ◽  
Vol 288 (1964) ◽  
Author(s):  
Erica O'Neill ◽  
Hannah E. Davis ◽  
Heath A. MacMillan
Keyword(s):  
Cold Tolerance ◽  
Thermal Tolerance ◽  
Regression To The Mean ◽  
Trade Off ◽  
Physiological Constraints ◽  
Chill Coma ◽  
Physiological Constraint ◽  
The Mean ◽  
High And Low Temperatures ◽  
The Individual

The thermotolerance–plasticity trade-off hypothesis predicts that ectotherms with greater basal thermal tolerance have a lower acclimation capacity. This hypothesis has been tested at both high and low temperatures but the results often conflict. If basal tolerance constrains plasticity (e.g. through shared mechanisms that create physiological constraints), it should be evident at the level of the individual, provided the trait measured is repeatable. Here, we used chill-coma onset temperature and chill-coma recovery time (CCO and CCRT; non-lethal thermal limits) to quantify cold tolerance of Drosophila melanogaster across two trials (pre- and post-acclimation). Cold acclimation improved cold tolerance, as expected, but individual measurements of CCO and CCRT in non-acclimated flies were not (or only slightly) repeatable. Surprisingly, however, there was still a strong correlation between basal tolerance and plasticity in cold-acclimated flies. We argue that this relationship is a statistical artefact (specifically, a manifestation of regression to the mean; RTM) and does not reflect a true trade-off or physiological constraint. Thermal tolerance trade-off patterns in previous studies that used similar methodology are thus likely to be impacted by RTM. Moving forward, controlling and/or correcting for RTM effects is critical to determining whether such a trade-off or physiological constraint exists.

scholarly journals A lack of repeatability creates the illusion of a trade-off between basal and plastic cold tolerance

2021 ◽  
Author(s):  
Erica O’Neill ◽  
Hannah E. Davis ◽  
Heath A. MacMillan
Keyword(s):  
Cold Tolerance ◽  
Thermal Tolerance ◽  
Regression To The Mean ◽  
Trade Off ◽  
Physiological Constraints ◽  
Chill Coma ◽  
Physiological Constraint ◽  
The Mean ◽  
High And Low Temperatures ◽  
The Individual

AbstractThe thermotolerance-plasticity trade-off hypothesis predicts that ectotherms with greater basal thermal tolerance have a lower acclimation capacity. This hypothesis has been tested at both high and low temperatures but the results often conflict. If basal tolerance constrains plasticity (e.g. through shared mechanisms that create physiological constraints), it should be evident at the level of the individual, provided the trait measured is repeatable. Here, we used chill-coma onset temperature and chill-coma recovery time (CCO and CCRT; non-lethal thermal limits) to quantify cold tolerance of Drosophila melanogaster across two trials (pre- and post-acclimation). Cold acclimation improved cold tolerance, as expected, but individual measurements of CCO and CCRT in non-acclimated flies were not (or only slightly) repeatable. Surprisingly, however, there was still a strong correlation between basal tolerance and plasticity in cold-acclimated flies. We argue that this relationship is a statistical artefact (specifically, a manifestation of regression to the mean; RTM) and does not reflect a true trade-off or physiological constraint. Thermal tolerance trade-off patterns in previous studies that used similar methodology are thus likely to be impacted by RTM. Moving forward, controlling and/or correcting for RTM effects is critical to determining whether such a trade-off or physiological constraint truly exists.

From “Strategic Partners” to “Strategic Competitors”: George W. Bush and the Politics of U.S. China Policy

2001 ◽  
Vol 1 (2) ◽  
pp. 191-220 ◽  
Author(s):  
Richard Baum
Keyword(s):  
Bush Administration ◽  
Status Quo ◽  
Strategic Partnership ◽  
Election Campaigns ◽  
Regression To The Mean ◽  
China Policy ◽  
The Status ◽  
The Mean ◽  
The Individual ◽  
The U.S

Ever since Richard Nixon's 1972 “opening” to China, U.S. presidential election campaigns have been the occasion for the opposition party to strongly challenge the incumbent president's policy of engagement toward China. Once in power, however, successful challengers (Carter, Reagan, Clinton) have softened their criticism and accepted the strategic necessity of cooperation with China. In the first stage of this cycle, the 2000 election appeared to be no exception, as presidential challenger George W. Bush sharply criticized Bill Clinton's notion of a “strategic partnership” with the PRC and proposed instead that the U.S. and China were “strategic competitors.” This paper examines the first six months of the Bush presidency to see if the historic pattern of post-election reversion to the status-quo ante is repeating itself in the Bush Administration. Looking, inter alia, at the individual preferences of key administration policymakers, the administration's enhanced arms sale package to Taiwan, the president's pledge to do “whatever it took” to defend Taiwan, and the mid-summer visit of Secretary of State Colin Powell to Beijing, the paper documents the existence of a sharp division between “soft” realists and “hard” realists within the Bush Administration; and it concludes that while there has been a perceptible shift toward a more adversarial outlook, it is too soon to tell whether this shift will be partly offset by the normal first-term “regression to the mean.”

scholarly journals Geographic variation in larval cold tolerance and exposure across the invasion front of a widely established forest insect

2021 ◽  
Author(s):  
Petra Hafker ◽  
Lily M Thompson ◽  
Dylan Parry ◽  
Jonathan A Walter ◽  
Kristine L Grayson
Keyword(s):  
Cold Tolerance ◽  
Thermal Tolerance ◽  
Sublethal Effects ◽  
Single Point ◽  
Cold Climate ◽  
Cold Temperature ◽  
Growth Responses ◽  
Forest Insect ◽  
Cold Temperatures ◽  
Chill Coma

As the global climate changes, high and low temperature extremes can drive changes in species distributions. Across the range of a species, thermal tolerance can experience plasticity and may undergo selection, shaping resilience to temperature stress. In this study, we measured variation in the lower thermal tolerance of early instar larvae of an invasive forest insect, Lymantria dispar dispar L. (Lepidoptera: Erebidae), using populations sourced from the climatically diverse invasion of the Eastern United States. In two chill coma recovery experiments, we recorded recovery time following a period of exposure to a non-lethal cold temperature. A third experiment quantified growth responses after chill coma recovery to evaluate sublethal effects. Our results indicate that cold tolerance is linked to regional climate, with individuals from cold climate populations recovering faster from chill coma. While this geographic gradient is seen in many species, detecting this pattern is notable for an introduced species founded from a single point-source introduction. We demonstrate that the cold temperatures used in our experiments occur in nature from cold snaps after spring hatching, but negative impacts to growth and survival appear low. We expect that population differences in cold temperature performance manifest more from differences in temperature-dependent growth than acute exposure. Evaluating intraspecific variation in cold tolerance increases our understanding of the role of climatic gradients on the physiology of an invasive species, and contributes to tools for predicting further expansion.

A Simple Method for the Evaluation of Internal Doses in Nuclear Medicine

1974 ◽  
Vol 13 (02) ◽  
pp. 193-206
Author(s):  
L. Conte ◽  
L. Mombelli ◽  
A. Vanoli
Keyword(s):  
Nuclear Medicine ◽  
Close Agreement ◽  
Whole Body ◽  
Simple Method ◽  
Rapid Estimation ◽  
Absorbed Doses ◽  
The Mean ◽  
The Individual ◽  
Estimation Of Risk

SummaryWe have put forward a method to be used in the field of nuclear medicine, for calculating internally absorbed doses in patients. The simplicity and flexibility of this method allow one to make a rapid estimation of risk both to the individual and to the population. In order to calculate the absorbed doses we based our procedure on the concept of the mean absorbed fraction, taking into account anatomical and functional variability which is highly important in the calculation of internal doses in children. With this aim in mind we prepared tables which take into consideration anatomical differences and which permit the calculation of the mean absorbed doses in the whole body, in the organs accumulating radioactivity, in the gonads and in the marrow; all this for those radionuclides most widely used in nuclear medicine. By comparing our results with dose obtained from the use of M.I.R.D.'s method it can be seen that when the errors inherent in these types of calculation are taken into account, the results of both methods are in close agreement.

SERUM THYROTROPHIN AND THE RESPONSE TO THYROTROPHIN RELEASING HORMONE IN SYMPTOMLESS AUTOIMMUNE THYROIDITIS AND IN BORDERLINE AND OVERT HYPOTHYROIDISM

1974 ◽  
Vol 75 (2) ◽  
pp. 274-285 ◽  
Author(s):  
A. Gordin ◽  
P. Saarinen ◽  
R. Pelkonen ◽  
B.-A. Lamberg
Keyword(s):  
Autoimmune Thyroiditis ◽  
Elevated Serum ◽  
Mean Value ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
The Individual ◽  
Serum Tsh

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

Welfare tradeoff psychology is present in children and adults

2018 ◽  
Author(s):  
Rhea M Howard ◽  
Annie C. Spokes ◽  
Samuel A Mehr ◽  
Max Krasnow
Keyword(s):  
Social Networks ◽  
Social Context ◽  
Opportunity Cost ◽  
Trade Off ◽  
Contextual Features ◽  
Limited Experience ◽  
The Individual

Making decisions in a social context often requires weighing one's own wants against the needs and preferences of others. Adults are adept at incorporating multiple contextual features when deciding how to trade off their welfare against another. For example, they are more willing to forgo a resource to benefit friends over strangers (a feature of the individual) or when the opportunity cost of giving up the resource is low (a feature of the situation). When does this capacity emerge in development? In Experiment 1 (N = 208), we assessed the decisions of 4- to 10-year-old children in a picture-based resource tradeoff task to test two questions: (1) When making repeated decisions to either benefit themselves or benefit another person, are children’s choices internally consistent with a particular valuation of that individual? (2) Do children value friends more highly than strangers and enemies? We find that children demonstrate consistent person-specific welfare valuations and value friends more highly than strangers and enemies. In Experiment 2 (N = 200), we tested adults using the same pictorial method. The pattern of results successfully replicated, but adults’ decisions were more consistent than children’s and they expressed more extreme valuations: relative to the children, they valued friends more and valued enemies less. We conclude that despite children’s limited experience allocating resources and navigating complex social networks, they behave like adults in that they reference a stable person-specific valuation when deciding whether to benefit themselves or another and that this rule is modulated by the child’s relationship with the target.

Quality of Life for Children with Persistent Sinonasal Symptoms

2003 ◽  
Vol 128 (1) ◽  
pp. 17-26 ◽  
Author(s):  
David J. Kay ◽  
Richard M. Rosenfeld
Keyword(s):  
Quality Of Life ◽  
Clinical Care ◽  
Longitudinal Change ◽  
Good Test ◽  
Routine Clinical Care ◽  
Before And After ◽  
The Mean ◽  
The Individual ◽  
Sinonasal Symptoms

OBJECTIVE: The goal was to validate the SN-5 survey as a measure of longitudinal change in health-related quality of life (HRQoL) for children with persistent sinonasal symptoms. DESIGN AND SETTING: We conducted a before and after study of 85 children aged 2 to 12 years in a metropolitan pediatric otolaryngology practice. Caregivers completed the SN-5 survey at entry and at least 4 weeks later. The survey included 5 symptom-cluster items covering the domains of sinus infection, nasal obstruction, allergy symptoms, emotional distress, and activity limitations. RESULTS: Good test-retest reliability ( R = 0.70) was obtained for the overall SN-5 score and the individual survey items ( R ≥ 0.58). The mean baseline SN-5 score was 3.8 (SD, 1.0) of a maximum of 7.0, with higher scores indicating poorer HRQoL. All SN-5 items had adequate correlation ( R ≥ 0.36) with external constructs. The mean change in SN-5 score after routine clinical care was 0.88 (SD, 1.19) with an effect size of 0.74 indicating good responsiveness to longitudinal change. The change scores correlated appropriately with changes in related external constructs ( R ≥ 0.42). CONCLUSIONS: The SN-5 is a valid, reliable, and responsive measure of HRQoL for children with persistent sinonasal symptoms, suitable for use in outcomes studies and routine clinical care.

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