scholarly journals Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons

2022 ◽  
Vol 377 (1845) ◽  
Author(s):  
Jordan A. Anderson ◽  
Amanda J. Lea ◽  
Tawni N. Voyles ◽  
Mercy Y. Akinyi ◽  
Ruth Nyakundi ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Bond Strength ◽  
Social Environment ◽  
Dominance Rank ◽  
Social Bond ◽  
Immune Gene ◽  
The Social ◽  
Social Environmental ◽  
Change Response ◽  
Wild Baboons

The social environment is a major determinant of morbidity, mortality and Darwinian fitness in social animals. Recent studies have begun to uncover the molecular processes associated with these relationships, but the degree to which they vary across different dimensions of the social environment remains unclear. Here, we draw on a long-term field study of wild baboons to compare the signatures of affiliative and competitive aspects of the social environment in white blood cell gene regulation, under both immune-stimulated and non-stimulated conditions. We find that the effects of dominance rank on gene expression are directionally opposite in males versus females, such that high-ranking males resemble low-ranking females, and vice versa. Among females, rank and social bond strength are both reflected in the activity of cellular metabolism and proliferation genes. However, while we observe pronounced rank-related differences in baseline immune gene activity, only bond strength predicts the fold-change response to immune (lipopolysaccharide) stimulation. Together, our results indicate that the directionality and magnitude of social effects on gene regulation depend on the aspect of the social environment under study. This heterogeneity may help explain why social environmental effects on health and longevity can also vary between measures. This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.

scholarly journals Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons

2021 ◽  
Author(s):  
Jordan Anderson ◽  
Amanda J Lea ◽  
Tawni Voyles ◽  
Mercy Akinyi ◽  
Ruth Nyakundi ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Bond Strength ◽  
Social Environment ◽  
Dominance Rank ◽  
Social Bond ◽  
Immune Gene ◽  
The Social ◽  
Social Environmental ◽  
Change Response ◽  
Wild Baboons

The social environment is a major determinant of morbidity, mortality, and Darwinian fitness in social animals. Recent studies have begun to uncover the molecular processes associated with these relationships, but the degree to which they vary across different dimensions of the social environment remains unclear. Here, we draw on a long-term field study of wild baboons to compare the signatures of affiliative and competitive aspects of the social environment in white blood cell gene regulation, under both immune stimulated and non-stimulated conditions. We find that the effects of dominance rank on gene expression are directionally opposite in males versus females, such that high-ranking males resemble low-ranking females, and vice-versa. Among females, rank and social bond strength are both reflected in the activity of cellular metabolism and proliferation genes. However, pronounced rank-related differences in baseline immune gene activity are near-absent for social bond strength, while only bond strength predicts the fold-change response to immune (lipopolysaccharide) stimulation. Together, our results indicate that the directionality and magnitude of social effects on gene regulation depend on the aspect of the social environment under study. This heterogeneity may help explain why social environmental effects on health and longevity can also vary between measures.

scholarly journals Social environment influences the relationship between genotype and gene expression in wild baboons

2013 ◽  
Vol 368 (1618) ◽  
pp. 20120345 ◽  
Author(s):  
Daniel E. Runcie ◽  
Ralph T. Wiedmann ◽  
Elizabeth A. Archie ◽  
Jeanne Altmann ◽  
Gregory A. Wray ◽  
...  
Keyword(s):  
Gene Expression ◽  
Individual Differences ◽  
Social Environment ◽  
Group Size ◽  
Early Life ◽  
Social Connectedness ◽  
Dominance Rank ◽  
Social Stressors ◽  
The Social ◽  
Wild Baboons

Variation in the social environment can have profound effects on survival and reproduction in wild social mammals. However, we know little about the degree to which these effects are influenced by genetic differences among individuals, and conversely, the degree to which social environmental variation mediates genetic reaction norms. To better understand these relationships, we investigated the potential for dominance rank, social connectedness and group size to modify the effects of genetic variation on gene expression in the wild baboons of the Amboseli basin. We found evidence for a number of gene–environment interactions (GEIs) associated with variation in the social environment, encompassing social environments experienced in adulthood as well as persistent effects of early life social environment. Social connectedness, maternal dominance rank and group size all interacted with genotype to influence gene expression in at least one sex, and either in early life or in adulthood. These results suggest that social and behavioural variation, akin to other factors such as age and sex, can impact the genotype–phenotype relationship. We conclude that GEIs mediated by the social environment are important in the evolution and maintenance of individual differences in wild social mammals, including individual differences in responses to social stressors.

scholarly journals The neighborhood social environment and physical activity: a systematic scoping review

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Maura M. Kepper ◽  
Candice A. Myers ◽  
Kara D. Denstel ◽  
Ruth F. Hunter ◽  
Win Guan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Social Environment ◽  
Scoping Review ◽  
Healthy Population ◽  
Aggregate Level ◽  
Eligibility Criteria ◽  
Environmental Correlates ◽  
The Social ◽  
Textual Data ◽  
Social Environmental

Abstract Background Investigating the association of the neighborhood social environment on physical activity is complex. A systematic scoping review was performed to (1) provide an inventory of studies assessing the influence of the neighborhood social environment on physical activity since 2006; (2) describe methodologies employed; and (3) formulate recommendations for the field. Methods Two databases were searched using terms related to ‘physical activity,’ ‘neighborhood,’ and ‘social environment’ in January 2017. Eligibility criteria included: 1) physical activity as an outcome; 2) neighborhood social environment as a predictor; 3) healthy population (without diagnosed clinical condition or special population); 4) observational or experimental design. Of 1352 studies identified, 181 were included. Textual data relevant to the social environment measurement and analysis were extracted from each article into qualitative software (MAXQDA) and coded to identify social environmental constructs, measurement methods, level of measurement (individual vs. aggregated to neighborhood), and whether authors explicitly recognized the construct as the social environment. The following measures were generated for each construct: number of unique measurements; % of times measured at an aggregate level; % of times authors referred to the construct as the social environment. Social environmental constructs were then grouped into larger descriptive dimensions. Results/findings Fifty-nine social environmental constructs were identified and grouped into 9 dimensions: Crime & Safety (n = 133 studies; included in 73% of studies); Economic & Social Disadvantage (n = 55, 33%); Social Cohesion & Capital (n = 47, 26%); Social Relationships (n = 22, 12%); Social Environment (n = 16, 9%); Disorder & Incivilities (n = 15, 8%); Sense of Place/Belonging (n = 8, 4%); Discrimination/Segregation (n = 3, 2%); Civic Participation & Engagement (n = 2, 1%). Across all articles, the social environment was measured using 176 different methods, was measured at an aggregate-level 38% of the time, and referred to as the social environment 23% of the time. Conclusions Inconsistent terminology, definitions, and measurement of the social environment and the lack of explicit language identifying constructs as the social environment make it challenging to compare results across studies and draw conclusions. Improvements are needed to increase our understanding of social environmental correlates and/or determinants of physical activity and facilitate cross-disciplinary conversations necessary to effectively intervene to promote physical activity. Trial registration PROSPERO CRD42017059580.

scholarly journals Group housing and social dominance hierarchy affect circadian activity patterns in mice

2021 ◽  
Vol 8 (2) ◽  
pp. 201985
Author(s):  
Yuri Robbers ◽  
Mayke M. H. Tersteeg ◽  
Johanna H. Meijer ◽  
Claudia P. Coomans
Keyword(s):  
Social Environment ◽  
Social Dominance ◽  
Dominance Hierarchy ◽  
Activity Patterns ◽  
Dominance Rank ◽  
Dominant Male ◽  
Group Housing ◽  
Male Mice ◽  
Female Mice ◽  
The Social

In this study, we investigated the effect of social environment on circadian patterns in activity by group housing either six male or six female mice together in a cage, under regular light–dark cycles. Based on the interactions among the animals, the social dominance rank of individual mice was quantitatively established by calculating Elo ratings. Our results indicated that, during our experiment, the social dominance hierarchy was rapidly established, stable yet complex, often showing more than one dominant mouse and several subordinate mice. Moreover, we found that especially dominant male mice, but not female mice, displayed a significantly higher fraction of their activity during daytime. This resulted in reduced rhythm amplitude in dominant males. After division into separate cages, male mice showed an enhancement of their 24 h rhythm, due to lower daytime activity. Recordings of several physiological parameters showed no evidence for reduced health as a potential consequence of reduced rhythm amplitude. For female mice, transfer to individual housing did not affect their daily activity pattern. We conclude that 24 h rhythms under light–dark cycles are influenced by the social environment in males but not in females, and lead to a decrement in behavioural rhythm amplitude that is larger in dominant mice.

scholarly journals Determinant of Diabetes Mellitus Focusing on Differences of Indonesian Culture: Case Studies in the Java and Outer Java Region in Indonesia

2020 ◽  
Vol 13 (1) ◽  
pp. 323-340
Author(s):  
Oktia W. K. Handayani ◽  
Efa Nugroho ◽  
Bertakalswa Hermawati
Keyword(s):  
Diabetes Mellitus ◽  
Social Environment ◽  
Management Program ◽  
Cultural Environment ◽  
Behavioral Differences ◽  
The Social ◽  
Social Environmental ◽  
Chronical Disease ◽  
Social Environmental Factors ◽  
And Behavior

Background: In 2017, Indonesia was ranked 6th in the world, with 10.3 million DM sufferers. Indonesia consists of many islands with diverse communities, diverse social and cultural environments, which allow different factors to affect the increasing number of DM cases. Objective: This research objective is to analyze the differences in the factors of the social environment, cultural environment, knowledge and behavior that are potential to DM in Java and outside Java. Methods: This research uses a quantitative approach with independent sample t-test data analysis techniques. The population was DM type 2 patients, with a sample size of 294 people. The technique was to determine the sample by accidental sampling in patients who seek treatment during prolanis (chronical disease management program) activities. The independent variables consist of social environment, cultural environment, knowledge and behavior. The dependent variable is DM disease. Data is equipped with qualitative data. Results: The results showed that there were differences between Javanese and Outer Java respondents on social environmental factors (t value 6.682), cultural environment (t value 5.752), knowledge (t value 7.079) and behavior (t value 16.579) with each Sig 0.000 value. All factors that are variables in this study have higher values in the Java region compared to those outside Java, and the highest difference is in the social environment variable (average difference of 3,979), which has an effect on very high behavioral differences (average differences average 6,037). Conclusion: It can be concluded that there are differences in the social environment, cultural environment, knowledge, and behavior that influence the incidence of diabetes mellitus in Indonesian society.

scholarly journals Assessment of the Social Environmental Accessibility for Persons with Disabilities (On the Example of the Republic of Mordovia)

2020 ◽  
Vol 19 (4) ◽  
pp. 161-169
Author(s):  
T.V. Soloveva ◽  
◽  
E.G. Pankova ◽  
D.A. Bistiakina ◽  
◽  
...  
Keyword(s):  
Social Environment ◽  
Objective Assessment ◽  
People With Disabilities ◽  
Sociological Research ◽  
Persons With Disabilities ◽  
The Social ◽  
The Republic ◽  
Social Environmental

the article presents the results of the author’s sociological research aimed at an objective assessment of the accessibility of the social environment and identification of problems of persons with disabilities related to the accessibility of the environment in the Republic of Mordovia. The authors also offer a number of recommendations for improving the development of the practice of providing an accessible environment based on the comments of people with disabilities in the region.

scholarly journals The Link Between Environment, Age, and Health in a Large Cohort of Companion Dogs from the Dog Aging Project

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 991-992
Author(s):  
Brianah McCoy ◽  
Layla Brassington ◽  
Greer Dolby ◽  
Kelly Jin ◽  
Devin Collins ◽  
...  
Keyword(s):  
Social Environment ◽  
Environment Impact ◽  
Wild Mammals ◽  
Factors Associated ◽  
Companion Dogs ◽  
The Social ◽  
Social Environmental ◽  
Set Up ◽  
Future Work ◽  
Health And Mortality

Abstract Exposure to social environmental adversity strongly predicts health and survival in many species such as non-human primates, wild mammals, and humans. However, little is known about how the health and mortality effects of these social determinants vary across the lifespan. Using the companion dog, which serves as a powerful comparative model for human health and aging due to our shared biology and environment, we examined which components of the social environment impact health, and how the effects vary with age, in dogs. We first drew on detailed survey data from owners of 27,547 dogs from the Dog Aging Project and identified six factors that together explained 35% of the variation in dog’s social environment. These factors all predicted measures of health, disease, and mobility, when controlling for dog age and weight. Factors capturing measures of financial and household adversity were linked to poorer companion dog health, while factors associated with the social companions, like dogs and adults, were linked to better health. Interestingly, some of these effects differed across a dog’s lifespan: for instance, the effect of neighborhood disadvantage on disease instances was strongest in older dogs. Together, our findings point to similar links between adversity and health in companion dogs, and set up future work on the molecular and biological changes associated with environmental variation in order to identify ways to mitigate or even reverse the negative environmental effects.

scholarly journals Pengaruh Waterfront Terhadap Kondisi Lingkungan Sosial Kelurahan Benua Melayu Laut

2021 ◽  
Vol 9 (1) ◽  
pp. 007
Author(s):  
Nana Novita Pratiwi
Keyword(s):  
Social Environment ◽  
Environmental Quality ◽  
Public Awareness ◽  
Composite Index ◽  
Negative Influence ◽  
Positive Influence ◽  
Negative Effects ◽  
The Social ◽  
Social Environmental ◽  
Index Value

Waterfront is a concept to support the availability of open spaces in Pontianak City. Besides functioning ecologically, Waterfront can also function aesthetically and economically so that its existence affects the social environment. One of the most popular Waterfront locations for visitors is the Waterfront  in Benua Melayu Laut Ubran Village. The study aims to determine the effect of the Waterfront on the conditions of the social environment in Benua Melayu Laut Urban Village. The analysis used is the frequency distribution and composite index. The results showed that the effect of Waterfront on social environmental conditions was high with an index value of 3.01. This influence can be in the form of a positive or negative influence. Positive influences include increased public awareness of the social environment, increased sense of responsibility in maintaining environmental quality, a high sense of care among fellow citizens and increased cooperation in improving environmental quality and aesthetics. The magnitude of this positive influence can have implications for the comfort and safety of the social environment. Meanwhile, the negative effects that can occur are high conflicts and unfair competition which have an effect on the decline in the social security of the Waterfront Benua Melayu Laut.

scholarly journals Faktor Yang Mempengaruhi Keinginan Investasi Investor Muda di Pasar Modal Indonesia

2020 ◽  
Vol 30 (5) ◽  
pp. 1084
Author(s):  
Riyadi Aprayuda ◽  
Fauzan Misra
Keyword(s):  
Social Environment ◽  
Capital Market ◽  
Structural Equation ◽  
Primary Data ◽  
Equation Modeling ◽  
The Social ◽  
Social Environmental ◽  
The Individual ◽  
The Impact ◽  
The Capital Market

This study aims to examine the influence of attitudes, the impact of the social environment, and investment knowledge on the desire to invest in the capital market by young investors. Specifically, this study refers to the predictors of Theory of Planned Behavior (Ajzen, 1991) to establish factors that influence investment desires. This study uses primary data from a closed questionnaire, with 166 valid responses through online surveys from investors in several university investment galleries in Indonesia. Data were analyzed using Structural Equation Modeling (SEM). The results showed that the attitude of investors and investment knowledge influence the desire to invest. However, the impact of the social environment did not succeed in triggering the investment desire of young investors. These finding underscores the influence of the social environment only being a support, meanwhile, the internal factors of the individual are the main ones making young investors want to invest. As a practical contribution, these finding suggest a positive attitude and increase investment-related knowledge can be applied as a strategy to attract new investors in the capital market. Keywords: Investment Intention; Investor's Attitude; Social Environmental Impacts; Investment knowledge; Young Investor.

EXPOSURE TO SUBSTANCE USE IN THE SOCIAL ENVIRONMENT: THE EXPERIENCES OF ADOLESCENTS IN THE TSHWANE METROPOLE

2015 ◽  
Vol 27 (3) ◽  
pp. 322-343
Author(s):  
Stephan Geyer ◽  
Liana Le Roux ◽  
Herna Hall
Keyword(s):  
Substance Use ◽  
Social Environment ◽  
Social Learning Theory ◽  
Research Approach ◽  
Structured Interviews ◽  
Developmental Approach ◽  
Sustainable Environment ◽  
The Social ◽  
Social Environmental ◽  
Social Environmental Factors

The premise of this study is that if exposure to substance use in the social environment of adolescents is understood, macro interventions could be recommended to promote adolescents’ right to live in a safe and sustainable environment. The aim of the study was to explore adolescents’ experiences of exposure to substance use in their social environment, other than the home. A qualitative research approach was adopted and 40 semi-structured interviews were conducted. Adolescent participants, of both genders between 11 and 18 years, were recruited across the Tshwane Metropole. The Social Learning Theory (SLT) underpinned this study as it offers concepts and principles for understanding how social environmental factors impact on adolescents’ behaviour. Key findings indicated that exposure to substance use are highly prevalent amongst adolescents in the Tshwane Metropole and could be normalised in their social reality. Recommendations are offered for appropriate macro interventions in line with a developmental approach.

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