scholarly journals The localized rise of a B.1.526 variant containing an E484K mutation in New York State

2021 ◽  
Author(s):  
Erica Lasek-Nesselquist ◽  
Pascal Lapierre ◽  
Erasmus Schneider ◽  
Kirsten St. George ◽  
Janice Pata
Keyword(s):  
New York ◽  
New York City ◽  
Monoclonal Antibodies ◽  
Metropolitan Area ◽  
York City ◽  
Neutralizing Antibodies ◽  
Immune Escape ◽  
New York State ◽  
Spike Protein ◽  
York State

The E484K mutation in the spike protein of SARS CoV-2 contributes to immune escape from monoclonal antibodies as well as neutralizing antibodies in COVID-19 convalescent plasma. It appears in two variants of concern: B.1.351 and P.1 but has evolved multiple times in different SARS-CoV-2 lineages, suggesting an adaptive advantage. Here we report on the emergence of a 484K variant in the B.1.526 lineage that has recently become prevalent in New York State, particularly in the New York City metropolitan area. In addition to the E484K mutation, these variants also harbor a D235G substitution in spike that might help to reduce the efficacy of neutralizing antibodies.

scholarly journals A statewide analysis of SARS-CoV-2 transmission in New York

2021 ◽  
Author(s):  
Erica Lasek-Nesselquist ◽  
Navjot Singh ◽  
Alexis Russell ◽  
Daryl Lamson ◽  
John Kelly ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
New York State ◽  
The United States ◽  
York State ◽  
Multiple Introductions ◽  
The Public ◽  
Travel Restrictions ◽  
Westchester County

AbstractNew York State, in particular the New York City metropolitan area, was the early epicenter of the SARS-CoV-2 pandemic in the United States. Similar to initial pandemic dynamics in many metropolitan areas, multiple introductions from various locations appear to have contributed to the swell of positive cases. However, representation and analysis of samples from New York regions outside the greater New York City area were lacking, as were SARS-CoV-2 genomes from the earliest cases associated with the Westchester County outbreak, which represents the first outbreak recorded in New York State. The Wadsworth Center, the public health laboratory of New York State, sought to characterize the transmission dynamics of SARS-CoV-2 across the entire state of New York from March to September with the addition of over 600 genomes from under-sampled and previously unsampled New York counties and to more fully understand the breadth of the initial outbreak in Westchester County. Additional sequencing confirmed the dominance of B.1 and descendant lineages (collectively referred to as B.1.X) in New York State. Community structure, phylogenetic, and phylogeographic analyses suggested that the Westchester outbreak was associated with continued transmission of the virus throughout the state, even after travel restrictions and the on-pause measures of March, contributing to a substantial proportion of the B.1 transmission clusters as of September 30th, 2020.

scholarly journals New York City’s Brownfield Redevelopment Program: Economic Catalyst or Taxpayer Giveaway?

2021 ◽  
Vol 12 (2) ◽  
pp. 1
Author(s):  
Tatyiana Gordon
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Financial Incentives ◽  
New York State ◽  
Property Values ◽  
Environmental Conservation ◽  
Hazardous Substances ◽  
York State Department ◽  
York State

The New York State Department of Environmental Conservation (DEC) and the New York City Office of Environmental Remediation (OER) manage and coordinate brownfield cleanup programs. These are intended to promote environmental restoration and redevelopment of underutilized or abandoned properties that have been affected by the presence or discharges of oil or hazardous substances. This paper seeks to determine whether these programs have achieved the goals and objectives sought by decision makers and if the cost of those achievements in terms of public money subsidies and forgone tax revenue have been commensurate with the realized benefits.The DEC brownfield program offers financial incentives, such as tax credits, as well as regulatory benefits (limited liability protections) to promote alternatives to greenfield development. OER efforts are New York City centric with incentives divided into three sectors: procedural, legal, and financial with a major goal of reducing remedial (cleanup) timeframes. To evaluate the effectiveness of the New York City Brownfield program changes in property values over time were evaluated. The five New York City counties experiencing the two highest percent increases in property values also claimed the highest brownfield credits. Queens and Brooklyn received most brownfield credits during this period but also experienced the most redevelopment. These and other data illustrate a return on the brownfield investment (ROBI) credit of about one to six; or one dollar in brownfield credit stimulating six dollars in project spending. New York City counties’ ROBI is consistent with all other New York State County ROBI’s: roughly six dollars in redevelopment activity being stimulated by one dollar in brownfield credit. The roughly $6 ROBI presented here is similar to ROI’s for other public services such as disease prevention and incarceration intervention.

The Borrower's Tale: A History of Poor Debtors inLochnerEra New York City

2012 ◽  
Vol 30 (4) ◽  
pp. 1053-1098 ◽  
Author(s):  
Anne Fleming
Keyword(s):  
New York ◽  
New York City ◽  
Interest Rate ◽  
York City ◽  
New York State ◽  
York State ◽  
Lower Manhattan ◽  
History Of ◽  
Office Manager

When asked why he did not read over the loan documents before signing them, John Doherty explained: “I was anxious to get the money, I didn't bother about it.” In February 1910, the twenty-three-year-old railroad clerk walked into the offices of the Chesterkirk Company, a loan-sharking operation with offices in lower Manhattan. He was looking to borrow some money. Repayment was guaranteed by the only security Doherty had to offer: his prospective wages and, in his words, his “reputation.” After a brief investigation of Doherty's creditworthiness, the loan was approved. The office manager placed a cross in lead pencil at the bottom of a lengthy form and Doherty signed where indicated. He received $34.85 in exchange for his promise to repay the loan principal plus $10.15 in combined fees and interest in three months. The interest charged was significantly greater than the 6 percent per year allowed in New York State. Doherty's effective annualized interest rate, including fees, was over 100 percent.

Utilization of peritoneal dialysis in the United States: Reasons for underutilization, specifically in New York State and the boroughs of New York City

2020 ◽  
Vol 33 (2) ◽  
pp. 140-147
Author(s):  
Ernie Yap ◽  
Marcia Joseph ◽  
Shuchita Sharma ◽  
Osama El Shamy ◽  
Alan D. Weinberg ◽  
...  
Keyword(s):  
United States ◽  
New York ◽  
New York City ◽  
Peritoneal Dialysis ◽  
York City ◽  
New York State ◽  
The United States ◽  
York State

Corruption and Racketeering in the New York City Construction Industry: The Final Report of the New York State Organized Crime Task Force.

ILR Review ◽  
1992 ◽  
Vol 45 (3) ◽  
pp. 606
Author(s):  
George W. Brooks ◽  
Ronald Goldstock ◽  
Martin Marcus ◽  
Thomas D. Thacher ◽  
James B. Jacobs
Keyword(s):  
New York ◽  
New York City ◽  
Construction Industry ◽  
Organized Crime ◽  
York City ◽  
Task Force ◽  
New York State ◽  
Final Report ◽  
York State ◽  
City Construction

Energy and Environmental Assessment of Plug-In Hybrid Vehicles in the New York Metropolitan Area Using MATPOWER Power System Simulation Package

2009 ◽  
Author(s):  
Jonathan Acquaviva ◽  
Earl Foster ◽  
Charles Ferdon ◽  
K. Max Zhang
Keyword(s):  
New York ◽  
New York City ◽  
Metropolitan Area ◽  
York City ◽  
Power Plants ◽  
New York State ◽  
Hybrid Vehicles ◽  
Future Climate Change ◽  
York Metropolitan Area ◽  
New York Metropolitan Area

The effects of plug-in hybrid vehicles in New York City could be substantial to the city’s efforts to achieve future climate change goals and environmental initiatives. This study focuses on these effects as they correlate to the energy supply system, transportation network, and air quality control. To accomplish this analysis a variety of techniques were used to model the transportation and electric networks around New York City. The transportation system is modeled through close manipulation of U.S Census Data collected in 2000 and 2003 in which citizens were asked questions pertaining to their daily journeys to work. The power grid for the Northeast Power Coordinating Council (NPCC) is modeled using a MATLAB program entitled MATPOWER developed by professors and students at Cornell University. By incorporating real-time load datum, this program has the capability of rendering accurate depictions of changes in power plant loads, emissions, and costs. In addition, the program will distinguish the type of energy used on the margin and locate the geographic region of that energy source. With this capability, the focus of this study surrounded three main objectives: to estimate market growth of PHEVs in the New York metropolitan area, investigate how fuel used to generate power changes with increase in demand, and to analyze the effects on emissions from cars and power plants. Initial analysis indicates that the introduction of plug-in hybrid electric vehicles into the New York City commuter fleet will have a net positive effect on reducing both total emissions and localized emissions around the city’s transportation infrastructure. At an ambitious rate of 20% PHEV penetration, New York could save nearly 625,000 gallons of gasoline per day. This is equivalent to 33,000 barrels of oil. At the current gasoline prices in New York State of $2.087 per gallon, this is a daily savings of $1.3 million dollars per day. In addition, at this penetration the PHEV’s would displace over 29,000 metric tonnes of net carbon dioxide per day.

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