scholarly journals THE EFFECT OF BARICITANIB USAGE ON THE CLINICAL AND BIOCHEMICAL PROFILES OF COVID-19 PATIENTS- A RETROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
Author(s):  
Anoop Amarnath ◽  
Ananya Das ◽  
Venkata Sai Shashank Mutya ◽  
Irfan Ibrahim
Keyword(s):  
Mortality Benefit ◽  
Oxygen Requirement ◽  
Exclusion Criteria ◽  
P Values ◽  
Survivor Group ◽  
Health Care Infrastructure ◽  
Huge Impact ◽  
Biochemical Profiles ◽  
Systemic Manifestations ◽  
Second Wave

Introduction: Coronaviruses typically cause influenza like illness which progresses to ARDS along with other systemic manifestations. India is experiencing its second wave with a huge surge in the number of cases exponentially causing huge impact on health care infrastructure and the demand supply chain. As a result several new modalities have been used, one of which is the use of remdesivir and baricitanib. Hence this study is aimed at finding out the clinical and biochemical profile of the patients who have received the combination Materials and Methods: All the patients who have received the combination meeting the inclusion and exclusion criteria have been included in the study. A total of 31 participants were included and their records were retrospectively analyzed. Results: There was a significant reduction in the oxygen requirement, CRP and IL-6 levels with p values<0.05. However, in the non-survivors group, there was no statistically significant reduction. Serial monitoring of NLR ratio showed increase towards the fifth day, especially in the non-survivor group it was as high as 41.24. The mortality rate was found to be 10% and the cause being secondary sepsis in all of them. Conclusion: The ACTT-2 trail has proved the efficacy of the use of the remdesivir and baricitanib combination with mortality benefit. In our study we found similar results which was well co-related with clinical and biochemical parameters like CRP and IL-6 especially in people with co-morbidites.

Correlation of Nitrite Oxide with Severity and Survival Rate of Sepsis Patients

2021 ◽  
Vol 28 (1) ◽  
pp. 61
Author(s):  
Sotianingsih Sotianingsih ◽  
Budi Mulyono ◽  
Andaru Dahesihdewi ◽  
Samsirun Halim ◽  
Ahmad Syauqi
Keyword(s):  
Nitric Oxide ◽  
Statistical Analysis ◽  
Survival Rate ◽  
Analytical Study ◽  
P Values ◽  
Nitrite Oxide ◽  
Risk Of Death ◽  
Survivor Group ◽  
Kinetics Of ◽  
Difference Test

The objective of this research was to determine the correlation between Nitric Oxide (NO) levels with the severity ofsepsis, to describe the kinetics of NO levels, and to evaluate it in predicting mortality. This research was a longitudinal cohortobservational analytical study. The variables were serum NO levels and SOFA scores, which were serially evaluated. Thecorrelation test and difference test were used for statistical analysis. The survivor and the non-survivor group consisted of 14(41.18%) and 20 (58.82%) patients, respectively. There was a correlation between serum NO levels and the SOFA score at the24-hour observation (r=0.403; p=0.041). Non-parametric Mann-Whitney test showed that there was no kinetics of NOth levels at 0, 24, 72, and 144-hour observation (p-values =0.897 and 0.703, respectively). NO levels > 111,16 μmol/L at the 24hour could predict the risk of death with hazard ratio 4.7 compared to NO levels < 111,16 μmol/L. The survival rate ofpatients with serum NO levels <111,16 μmol/L and > 111,16 μmol/L was 83.3% and 37.5%, respectively. There was acorrelation between serum NO levels and SOFA scores at the 24-hour observation. However, there was no kinetics of NOlevels at serial evaluations. Nitric oxide levels with a cut-off of 111,16 μmol/L at 24 hours could predict the survival of septicth patients. Utilization of serum NO level at 24 hour can be used to evaluate the severity of septic patients and aggressivemanagement if there is an increase in serum NO levels > 111,16 μmol/L at 24 hours.

Aplicación del cuestionario mcgill en mujeres con fibromialgia y con lombalgia: un estudio comparativo

2009 ◽  
Vol 3 (4) ◽  
pp. 875
Author(s):  
Ana Claudia de Souza Leite ◽  
Weidinara De Oliveira Rodrigues ◽  
Lorita Marlena Freitag Pagliuca
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Cognitive Deficits ◽  
Case Control Study ◽  
Ethics Committee ◽  
Clinical Group ◽  
Low Back ◽  
Exclusion Criteria ◽  
P Values ◽  
Control Study

Objective: to apply the McGill Questionnaire, translated and adapted to Brazil, and to identify the degree of internal association between this clinical group of women with fibromyalgia and another group of women with low back pain. Methods: this experimental research includes a case-control study. The population consisted of 83 patients diagnosed with fibromyalgia and low back pain who attended the Orthopedics and Trauma Outpatient Clinic at a Teaching Hospital in Fortaleza-CE, Brazil, from December 2005 to June 2006. The following exclusion criteria were adopted: patients with sensory and cognitive deficits, illiterate, younger than 21 and older than 60 years. A sample of 50 patients was obtained. The control and experimental groups were paired and the MPQ was applied to both. This study has been approved by the Research Ethics Committee of the Federal University of Ceará (04545014-5). Results: were analyzed comparatively through non-parametrical statistics (Kruskal-Wallis). This test found significant means and standard deviations for the sensory and affective categories, with significant p-values for the descriptor “tiring”. Conclusion: the MPQ showed its appropriateness for pain assessment and analysis in fibromyalgia patients. Descriptors: pain; pain measurement; fibromyalgia.

scholarly journals EP.WE.433Assessment of the temporary Surgical ED Study and Audit

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Mostafa Abdelkarim ◽  
Syed Nawaz ◽  
Gowtham Venkatesan ◽  
Sreedut Murali ◽  
Ahmed Asqalan ◽  
...  
Keyword(s):  
Emergency Department ◽  
Hospital Services ◽  
Medical Patients ◽  
Inclusion Criteria ◽  
Front Line ◽  
Exclusion Criteria ◽  
X Ray ◽  
Surgical Emergency ◽  
Huge Impact ◽  
Dedicated Team

Abstract Aims To ascertain the effectiveness of the newly formed surgical ED during Covid-19 outbreak in terms of: Methods/Study design Retrospective cohort of 992 patients were identified and included from the period of the 5th April to 5th May 2020 Inclusion criteria: All patients attended and triaged in the new surgical emergency department. Exclusion criteria: Patients who were not triaged. Results The temporary surgical emergency department was successful in accommodating all surgical patients categorized 2, 3 and 4 with category 4 being the highest number at 45%. Hospital services were successfully accessed in 771(77.72%) during patients stay in ED including Bloods and imaging with X-ray as the most service used at 42.33%. 221(22.27%) patients didn’t require any investigations and were discharged after review by the surgical doctor within the 4-hour window. Conclusion Presence of a dedicated surgical emergency during the covid period was essential to separate medical patients from non-medical patients. Having a decision maker on the front line right after triage has reduced the overall number of admissions, number of emergency breeches and unnecessary investigations. Having a dedicated space with dedicated team could make a huge impact on the service in terms of time, effort and money spent.

scholarly journals The Differences of Electrolyte and Cardiac Markers Levels in NSTEMI and STEMI Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 1987-1990
Author(s):  
Freddy Ciptono ◽  
Banundari Rachmawati ◽  
Meita Hendrianingtyas
Keyword(s):  
Potassium Chloride ◽  
Troponin I ◽  
Cardiac Markers ◽  
Elisa Method ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Sodium Potassium ◽  
P Values ◽  
Observational Study Design ◽  
The Difference

Background: Coronary heart disease (CHD) has become the leading cause of mortality in the world. Myocardial infarction is the most common form of CHD, which consists of NSTEMI and STEMI. Differences of sodium, potassium, chloride, troponin I and NT-ProBNP levels on NSTEMI and STEMI were not widely discussed. Previous studies of electrolyte levels and NT-ProBNP gave different results. Aim: To analyze the differences of serum sodium, potassium, chloride, troponin I and NT-ProBNP levels in NSTEMI and STEMI patients. Methods: Analytic observational study design with cross sectional approach was conducted in February-May 2019 involving 35 NSTEMI and 35 STEMI patients at the Dr. Kariadi General Hospital ED who were screened according to the inclusion and exclusion criteria. Sodium, potassium and chloride levels were measured using the ISE method of the Advia biochemistry system. Troponin I levels were measured by the ELFA method on Vidas mini and NT-ProBNP levels were using the ELISA method. Differences in sodium, potassium and chloride levels between groups were analyzed using independent t-test, differences in troponin I and NT-ProBNP levels between groups were analyzed using Mann Whitney U Test. p values were considered significant if less than 0.05. Results: There are significant differences in levels of sodium (p=0.001), chloride (p=0.030), troponin I (p<0.001) and NT-ProBNP (p=0.001) between NSTEMI and STEMI patients. The difference of potassium levels is not significant between the two groups (p=0.721). Conclusion: Lower levels of sodium and chloride, higher troponin I and NT-ProBNP levels occur in STEMI rather than NSTEMI. Keywords: Electrolyte, Troponin I, NT-ProBNP, NSTEMI, STEMI

scholarly journals The Effect of Citicoline on Electroretinography Abnormalities in Patients with Non-proliferative Diabetic Retinopathy

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Anna Nur Utami ◽  
Elvioza Elvioza ◽  
M Sidik
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Primary Outcome ◽  
Positive Trend ◽  
Exclusion Criteria ◽  
Double Blind ◽  
P Values ◽  
Oral Supplementation ◽  
End Of Treatment ◽  
Before And After

Introduction : to determine the effect of citicoline 1000 mg oral supplementation given for 4 weeks on electroretinography abnormalities in patients with NPDR (non-proliferative diabetic retinopathy). Methods : prospective, double blind, randomized clinical trial. Thirty-eight patients who matched the inclusion and exclusion criteria were randomized into two groups: the placebo (P-NPDR) and citicoline (C-NPDR).  In the end, there were 18 eyes in citicoline group and 16 eyes in placebo group. The primary outcome was P50 and N95 amplitude in PERG within group and intergroup which were taken at the baseline and 4 weeks after treatment. Results : at the end of treatment, the N95 amplitude in C-NPDR showed improvement, 4.85 (1.9-10.3) µV, before treatment to 5.7 (1.9-17.1) µV, after treatment with P = 0.04. Median P50 amplitude improved in both groups, with C-NPDR: 3.1 µV to 3.8 µV (p = 0.89), and P-NPDR: 3.5 µV, to 4.5 µV (p = 0.10). Delta ∆N95 amplitude is higher in C-NPDR, while delta ∆P50 amplitude is higher in P-NPDR, with P values 0.35 and 0.45. Conclusion : Oral citicoline may induce a significant improvement in mean N95 amplitude before and after the treatment. P-NPDR showed positive trend in P50 amplitude while in C-NPDR showed positive trend in N95 amplitude, but these values were not statistically significant (P = 0.45; P= 0.35).

scholarly journals A Comparative Study of Nomegestrol Acetate and a Combination of Ethinylestradiol and Levonorgestrel for Delaying Menstruation among Umrah Pilgrims

2018 ◽  
pp. 45
Author(s):  
Mirzah Tindar ◽  
Yusuf Effendi ◽  
Adenan Abadi ◽  
Theodorus Theodorus
Keyword(s):  
Side Effects ◽  
Obstet Gynecol ◽  
Controlled Trial ◽  
Exclusion Criteria ◽  
Chi Square ◽  
P Values ◽  
Randomized Controlled ◽  
Nomegestrol Acetate ◽  
Chi Square Test ◽  
Single Blind

Objective: To compare the effectiveness efficacy of nomegestrolacetate with and combination of ethinylestradiol and levonorgestrelas a regimen for delaying menstruation in Umrah pilgrims in Palembangcity.Methods: This single-blind randomized controlled trial was conductedin Hajj and Umrah Guidance Group in Palembang city duringDecember 2016 to January 2017. Population of this study was 30women who meet the inclusion and exclusion criteria. Frequencyand distribution of data was described in a table. Effectiveness andthe side effects treatment between the two groups were analyzedwith Chi Square test. Data was were analyzed using SPSS version18.0.Results: There were no differences in age, education, occupation,parity, body weight, height and contraceptive history betweentwo both groups (all p values > 0.05). Statistical analysis showedthere was no difference in spotting between nomegestrol acetate5 mg or a combination of levonorgestrel 150 mcg and 30 mcgethinylestradiol in Umrah pilgrims (p = 1.000). Other side effectssuch as (dizziness, depression, breast tenderness, heavy limbs,nauseam and vomiting) between the two groups could not beanalyzed because all subjects did not experience any other sideeffects.Conclusion: There is no difference in effectiveness betweennomegestrol acetate 5 mg or combination of levonorgestrel 150mcg and 30 mcg ethinylestradiol as a regimen for delayingmenses in Umrah pilgrims in Palembang city.[Indones J Obstet Gynecol 2018; 6-1: 45-49]Keywords: delay menstruation, ethinylestradiol, levonorgestrel,nomegestrol, side effects, spotting, umrah

scholarly journals Catastrophic COVID-19 Second Wave in Aligarh: Lessons learnt

2021 ◽  
pp. 140-143
Author(s):  
Syed Ziaur Rahman ◽  
Saif Khan ◽  
- Shujauddin
Keyword(s):  
Health Care ◽  
Medical Science ◽  
Uttar Pradesh ◽  
Past Experience ◽  
The State ◽  
Third Wave ◽  
The Past ◽  
Lessons Learnt ◽  
Health Care Infrastructure ◽  
Second Wave

The second wave of COVID-19 in India showed its devastated effect mainly in April-May 2021 and crumbled the whole health care infrastructure. Demand for medical oxygen was higher during the second wave of COVID-19 pandemic in comparison to the first spell. Three states viz Maharashtra, Uttar Pradesh and Delhi were more severely affected. Aligarh, a small district of around 1.8 million population lies in the state of Uttar Pradesh (UP). The district is famous as ‘Oxford of the East’ due to large number of intellectuals and teachers living and working at Aligarh Muslim University, was obviously not left unsaved in this second wave. The present paper discussed the catastrophic effect of COVID-19 second wave in Aligarh, the possible reasons behind it, preparation for the anticipated third wave and lessons learnt from the past experience. Bangladesh Journal of Medical Science Vol.20(5) 2021 p.140-143

scholarly journals HEPATIC ENCEPHALOPATHY;

2017 ◽  
Vol 24 (07) ◽  
pp. 947-951
Author(s):  
Mazhar Hussain ◽  
Habib-Ur- Rehman ◽  
Lubna Akhtar ◽  
Muhammad Bilal Ghafoor
Keyword(s):  
Hepatic Encephalopathy ◽  
Mortality Benefit ◽  
Duration Of Symptoms ◽  
P Values ◽  
Significant Difference ◽  
Group A ◽  
Varied Response ◽  
The Mean ◽  
Randomized Control ◽  
Group B

Background: Hepatic encephalopathy is one of the fatal complications of livercirrhosis in clinical setting. A number of drugs with varied response have been tried up till now.Objectives: To compare the efficacy of lactulsoe alone and in combination with rifaxamin incases with hepatic encephalopathy. Study Design: Randomized control trail. Setting: SheikhZayed Hospital (SZH) Rahim Yar Khan (RYK). Period: January 2015 to October 2015. Patientsand Methods: 120 cases of liver cirrhosis with encephalopathy were randomized into differentgrades according to West Haven’s criteria. These cases were then equally divided into group Aand B. Group A was treated with lactulose alone while group B was treated with lactulose plusrifaxamin with their standard doses. The cases were assessed for their improvement in symptomson West Haven’s scale and the cases with complete resolution of symptoms were labeled ascured. The mortality benefit was also noted. Results: The mean age was 43.24± 8.34 yearsand mean duration of symptoms was 3.45± 0.8 days. There was no significant difference interms of child pugh score in both groups with p= 0.69. There was also no significant differencein both groups in terms of grades of encephalopathy (p= 0.21). However there was significantbetter efficacy and decreased mortality in group B as compared to A with p values of 0.02 and0.03 respectively. Conclusion: Lactulose combined with rifaxamin has significant improvementin encephalopathy as well as in reducing mortality in comparison with lactulsoe alone

A rapid method for the direct identification of paramyxovirus in canine CSF by ultracentrifugation and negative staining as a rule out for distemper

1990 ◽  
Vol 48 (3) ◽  
pp. 594-595
Author(s):  
W.L. Steffens ◽  
M.B. Ard ◽  
C.E. Greene ◽  
A. Jaggy
Keyword(s):  
Subacute Sclerosing Panencephalitis ◽  
Clinical Signs ◽  
Viral Disease ◽  
Etiologic Agent ◽  
Mucosal Inflammation ◽  
Worldwide Distribution ◽  
Negative Stain ◽  
Viral Particles ◽  
Systemic Manifestations ◽  
Rule Out

Canine distemper is a multisystemic contagious viral disease having a worldwide distribution, a high mortality rate, and significant central neurologic system (CNS) complications. In its systemic manifestations, it is often presumptively diagnosed on the basis of clinical signs and history. Few definitive antemortem diagnostic tests exist, and most are limited to the detection of viral antigen by immunofluorescence techniques on tissues or cytologic specimens or high immunoglobulin levels in CSF (cerebrospinal fluid). Diagnosis of CNS distemper is often unreliable due to the relatively low cell count in CSF (<50 cells/μl) and the binding of blocking immunoglobulins in CSF to cell surfaces. A more reliable and definitive test might be possible utilizing direct morphologic detection of the etiologic agent. Distemper is the canine equivalent of human measles, in that both involve a closely related member of the Paramyxoviridae, both produce mucosal inflammation, and may produce CNS complications. In humans, diagnosis of measles-induced subacute sclerosing panencephalitis is through negative stain identification of whole or incomplete viral particles in patient CSF.

Issues and pitfalls in the use of p-values

2020 ◽  
Author(s):  
Michel Jacques Counotte ◽  
Shannon Axiak Flammer ◽  
Sonja Hartnack
Keyword(s):  
P Values
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