Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil

Objective: To describe trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination. Design: A retrospective study was conducted in children (0-18 years), admitted in two pediatric hospitals of Rio de Janeiro city, between January 17 and July 3, 2021 with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil and the pre-vaccine period were measured by linear regression. Participants: Children admitted in pediatric hospitals in Rio de Janeiro, city, Brazil Results: The number of total admitted patients (with all diseases) were 5340 during the pre-vaccine period, being 94 (1.8%) of them with confirmed COVID-19, and 4182 children admitted during the vaccine period, with 86 confirmed COVID-19 patients (2.1 %) (p=0.29). Media of cases admitted per/week were 2.02 in pre-vaccine period and 3.6 during the first 24 weeks of COVID vaccination (p=0.009). One death was reported in the pre-vaccine period and four in the vaccine period (p=0.14). Trends of increase in the number of admitted cases were verified both in the pre-vaccine period as in the vaccine period, being more expressive in the last one. Conclusion: There was trend of increase in number of children admitted with confirmed COVID-19 during the first 24 weeks of COVID-vaccination in Rio de Janeiro, city. Considering that few people were fully vaccinated, reducing of number of admitted children with confirmed COVID-19 was not verified.

Download Full-text

Indirect impact on number of admitted children with COVID-19 in the first three months of emergency use of two vaccines, in Rio de Janeiro, Brazil

10.1101/2021.07.01.21259330 ◽

2021 ◽

Author(s):

CARLOS Gabriel Brandao Fonseca ◽

Ana Luisa Torres Guimaraes Costa ◽

Monica Del Monaco Esteves ◽

Bernardo Rodrigues Rosa de Carvalho ◽

Cristina Vieira Souza ◽

...

Keyword(s):

Rio De Janeiro ◽

Clinical Signs ◽

P Value ◽

Chain Reaction ◽

Serological Tests ◽

Pediatric Hospitals ◽

Indirect Impact ◽

Polymerase Chain ◽

The City ◽

All Diseases

Introduction: Since January 19, 2021, two vaccines against SARS-COV-2 are available in Brazil for emergency use for selected groups, not including children. Aim: To describe indirect impact on the number of hospitalized children with COVID-19 in the first three months after beginning of emergency use of two vaccines. Methods: A retrospective study was conducted in children (0-18 years), admitted in two pediatric hospitals of Rio de Janeiro city, between January and April 2021 with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Number of cases, clinical signs, symptoms and outcomes were compared with the first wave of disease (April- June 2020). A p value of less than .05 were considered was significant. Results: The number of total admitted patients (with all diseases) were 1097 in 2020 period, being 46 (4.2%) of them with confirmed COVID-19, and 2187 in the 2021 period, with 47 (2.1%) cases (p=0.006). Predominant respiratory symptoms were present in 29/46 (63%) as the main presentation in 2020 patients and 37/47 (78.7%) in 2021 children (p=0.09). The main symptoms were fever, cough and dyspnoea in both periods. The median of lenght of stay after diagnosis were 4 days in 2020 and 2021 ( p=0.9). Just one patient died in 2021. Conclusion: There was reduction of relative percentage of admitted confirmed pediatric cases in the the first three months of emergency use of two vaccines against SARS-COV-2, but it is uncertain to atribute this finding to vaccination due to high circulation of the virus in the city.

Download Full-text

Respiratory and non-respiratory manifestations in children admitted with COVID 19 in Rio de Janeiro city, Brazil

10.1101/2020.12.29.20248994 ◽

2021 ◽

Author(s):

AR Araujo da Silva ◽

CGB Fonseca ◽

JLPS Miranda ◽

BV Travassos ◽

CR Baião ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Length Of Stay ◽

Respiratory Symptoms ◽

C Reactive Protein ◽

Chain Reaction ◽

Serological Tests ◽

Main Symptom ◽

Reactive Protein ◽

Polymerase Chain ◽

Janeiro City

AbstractIntroductionCOVID 19 is still a challenge in pediatrics due to variety of symptoms and different presentationsAimTo describe clinical, laboratorial and treatment of confirmed COVID-19 pediatric admitted in hospitals.MethodsA retrospective study was conducted in children (0-18 years), admitted between March and November 15, 2020, with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Clinical data about symptoms, laboratorial exams and treatments were analysed. Patients were evaluated according predominant (PRS) or non-predominant respiratory symptoms (non-PRS)ResultsSixty-four patients were evaluated, being the median age 5.6 years. Forty-seven (73.4%) children were admitted with PRS and 17 (26.4%) with non-PRS. The main symptoms in the PRS group were fever in 74.5% of children and cough in 66%; and fever in 76.5% and edema/cavitary effusion in 29.4% in the non-PRS group. The median of C-reactive protein (in mg/dl) was 2.5 in the PRS group and 6.1 in the non-PRS group. Antibiotics were used in 85.1% of the PRS group and 94.1% of non-group. Comorbidity was present in 30/47 (63.8%) of PRS group and 8/17 (47.1%) of non-PRS group (p=0.22). Length of stay until 7 days in patients with comorbidity was present in 27/64 (42.1%) and more than 7 days in 11/64 (17.1%) (p= 0.2)ConclusionNon-PRS represented more than one quarter of admitted patients. Fever was the main symptom detected, elevated CRP was frequent and antibiotics were commonly prescribed. Comorbidity was found in both groups and his presence was not associated with a longer length of stay.

Download Full-text

Detection of human papillomavirus in esophageal and gastroesophageal junction tumors: A retrospective study by real-time polymerase chain reaction in an instutional experience from Turkey and review of literature

Pathology - Research and Practice ◽

10.1016/j.prp.2015.10.007 ◽

2016 ◽

Vol 212 (2) ◽

pp. 77-82 ◽

Cited By ~ 10

Author(s):

Düriye Özer Türkay ◽

Çiğdem Vural ◽

Murat Sayan ◽

Yeşim Gürbüz

Keyword(s):

Polymerase Chain Reaction ◽

Human Papillomavirus ◽

Retrospective Study ◽

Real Time ◽

Gastroesophageal Junction ◽

Review Of Literature ◽

Chain Reaction ◽

Polymerase Chain

Download Full-text

Comparison of multiplex real-time polymerase chain reaction with serological tests and culture for diagnosing human brucellosis

Journal of Infection and Public Health ◽

10.1016/j.jiph.2018.11.008 ◽

2019 ◽

Vol 12 (3) ◽

pp. 337-342 ◽

Cited By ~ 7

Author(s):

Tuba Dal ◽

Soner Sertan Kara ◽

Aytekin Cikman ◽

Cigdem Eda Balkan ◽

Ziya Cibali Acıkgoz ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Real Time ◽

Human Brucellosis ◽

Chain Reaction ◽

Serological Tests ◽

Polymerase Chain

Download Full-text

USE OF THE POLYMERASE CHAIN REACTION FOR THE DIAGNOSIS OF ASYMPTOMATIC Leishmania INFECTION IN A VISCERAL LEISHMANIASIS-ENDEMIC AREA

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652013000200006 ◽

2013 ◽

Vol 55 (2) ◽

pp. 101-104 ◽

Cited By ~ 17

Author(s):

Luciana Almeida Silva ◽

Héctor Dardo Romero ◽

Aline Fagundes ◽

Nédia Nehme ◽

Otávio Fernandes ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Visceral Leishmaniasis ◽

Endemic Area ◽

Asymptomatic Infection ◽

Control Measures ◽

Skin Tests ◽

Leishmania Infection ◽

Chain Reaction ◽

Serological Tests ◽

Polymerase Chain

The diagnosis of asymptomatic infection with Leishmania (Leishmania) chagasi has become more important over recent years. Expansion of visceral leishmaniasis might be associated with other routes of transmission such as transfusion, congenital or even vector transmission, and subjects with asymptomatic infection are potential reservoirs. Moreover, the identification of infection may contribute to the management of patients with immunosuppressive conditions (HIV, transplants, use of immunomodulators) and to the assessment of the effectiveness of control measures. In this study, 149 subjects living in a visceral leishmaniasis endemic area were evaluated clinically and submitted to genus-specific polymerase chain reaction (PCR), serological testing, and the Montenegro skin test. Forty-nine (32.9%) of the subjects had a positive PCR result and none of them developed the disease within a follow-up period of three years. No association was observed between the results of PCR, serological and skin tests. A positive PCR result in subjects from the endemic area did not indicate a risk of progression to visceral leishmaniasis and was not associated with a positive result in the serological tests.

Download Full-text

Feasibility and safety of a symptom-based strategy to discontinue infection control precautions for patients hospitalised with COVID-19 – a retrospective study

International Journal of Infection Control ◽

10.3396/ijic.v17.20601 ◽

2021 ◽

Author(s):

Gaël Grandmaison ◽

Marine Baumberger ◽

Charlotte Pellaud ◽

Véronique Erard ◽

Christian Chuard

Keyword(s):

Polymerase Chain Reaction ◽

Retrospective Study ◽

Infection Control ◽

Median Time ◽

Median Number ◽

Rt Pcr ◽

Chain Reaction ◽

Clinical Criteria ◽

Polymerase Chain ◽

Hospital Acquired

Background: Various recommendations exist concerning the discontinuation of contact and droplet precautions (CDP) for patients hospitalised with coronavirus disease 2019 (COVID-19). Some are based on repeated negative real-time polymerase chain reaction (RT-PCR) results, whereas other are based on clinical criteria. The feasibility and safety of these recommendations are poorly documented. Method: We conducted a retrospective study to assess the feasibility and safety of a symptom-based strategy to discontinue CDP for patients hospitalised with COVID-19. We reviewed the clinical charts of all symptomatic patients hospitalised in our institution with RT-PCR-confirmed COVID-19 to assess the application of a symptom-based strategy for the implementation and discontinuation of CDP. The patients with discontinuation of CDP in accordance with the symptom-based strategy were cross-referenced with patients with potential hospital-acquired COVID-19 in order to assess the safety of this strategy. Results: Among the 147 patients included in our study, our symptom-based strategy was respected in 95 cases (64.6%). Discontinuation of CDP in accordance with the recommendations occurred in 39 patients (26.5%). After the discontinuation of CDP, patients remained hospitalised for a median time of 18 days, with exposure to a median number of three patients, resulting in a total number of 588 days ‘patient-day-exposition’. No hospital-acquired COVID-19 was detected in contact patients. Discussion: The use of a symptom-based strategy to discontinue CDP is applicable and safe. This symptom-based strategy was applicable regardless of patient’s age or COVID-19 severity.

Download Full-text