scholarly journals Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior

Author(s):  
Margaret L. Westwater ◽  
Alexander G. Murley ◽  
Kelly M.J. Diederen ◽  
T. Adrian Carpenter ◽  
Hisham Ziauddeen ◽  
...  

AbstractBackgroundAnorexia nervosa (AN) and bulimia nervosa (BN) are associated with altered brain structure and function, as well as increased habitual behavior. This neurobehavioral profile may implicate neurochemical changes in the pathogenesis of these illnesses. Altered glutamate, myo-inositol and N-acetyl aspartate (NAA) concentrations are reported in restrictive AN, yet whether these extend to binge-eating disorders, or relate to habitual traits in affected individuals, remains unknown.MethodsUsing single-voxel proton magnetic resonance spectroscopy, we measured glutamate, myo-inositol and NAA in 85 women [n=22 AN (binge-eating/purging subtype; AN-BP), n=33 BN, n=30 controls]. Spectra were acquired from the right inferior lateral prefrontal cortex and the right occipital cortex. To index habitual behavior, participants performed an instrumental learning task and completed the Creature of Habit Scale. Exploratory analyses examined associations between metabolites and habitual behavior.ResultsWomen with AN-BP, but not BN, had reduced myo-inositol and NAA concentrations relative to controls in both voxels. Patient groups had intact performance on the instrumental learning task; however, both groups reported increased routine behaviors compared to controls. Women with BN also reported greater automatic behaviors, and automaticity was related to reduced prefrontal glutamate and NAA in the AN-BP group.DiscussionFindings extend previous reports of reduced myo-inositol and NAA levels in AN to AN-BP, which may reflect disrupted axonal-glial signaling. Although we found inconsistent support for increased habitual behavior in AN-BP and BN, we identified preliminary associations between prefrontal metabolites and automaticity in AN-BP. These results provide further evidence of unique neurobiological profiles across binge-eating disorders.

Author(s):  
Lise Katrine Jepsen Trangsrud ◽  
Marit Borg ◽  
Solfrid Bratland-Sanda ◽  
Trude Klevan

Eating disorders can be understood as attempts to manage a problematic relationship with one’s own body. The objective of this qualitative study was to explore and discuss perspectives of embodying “experiences with nature” related to recovery in everyday life for persons experiencing eating disorders. The study was carried out in the context of a hermeneutic phenomenological approach. Eight participants with an interest in nature and friluftsliv (outdoor pursuits), and with experiences with bulimia nervosa and/or binge-eating disorders, were interviewed twice. Interviews took place in nature, in combination with a “going together” method. The results reveal how the participants highlighted experiences with nature as accentuating feelings of calmness and an engagement of the senses. Participants described nature as a non-judgmental environment that also provided room for self-care. This article explores the implications of everyday life perspectives on nature in recovery, as well as of an integrated focus on body and mind in experiences with eating disorders. The article concludes with an emphasis on how participant’s embodying experiences with nature enabled a (re)connection with one’s own body.


2004 ◽  
Vol 35 (4) ◽  
pp. 26-34
Author(s):  
Ebony M. Hogan ◽  
Connie J. McReynolds

This article addresses anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorders (BED) through the discussion of demographic information, symptomatology, DSM IV criteria for diagnosis, etiology, current treatment modalities, and the potential prognosis of each of these disorders. Additional information about an eating disorder that exclusively affects men is also provided. Intervention strategies for each eating disorder, as well as the relapse phenomenon affecting recovery from eating disorders, are discussed. Specific suggestions are provided for rehabilitation counselors as well as suggestions for future research.


2020 ◽  
Vol 26 (12) ◽  
pp. 1502-1509
Author(s):  
Huda Al Hourani ◽  
Rana Ababneh ◽  
Nahla Khawaja ◽  
Yousef Khader ◽  
Kamel Ajlouni

Background: Studies on eating disorders among Jordanian adolescents have reported variable prevalence rates of 12–40%. Aims: This study aimed to determine the prevalence of eating disorders among Jordanian adolescents with and without dysglycaemia and determine the associated factors. Methods: A comparative cross-sectional study was conducted during the period November 2017–February 2018. The Eating Disorder Diagnostic Scale was used to assess the presence of different types of eating disorders, including anorexia nervosa, bulimia nervosa and binge eating disorder. A typical anorexia nervosa and purging disorder were considered “other eating disorders” in this study. Results: This study included 497 patients with dysglycaemia and 504 age-matched nondysglycaemic participants. Patients with dysglycaemia had a significantly higher prevalence of binge eating disorders compared with nondysglycaemic participants (11.9% vs 5.8%, P < 0.001). In dysglycaemia group, adolescents who were aged ≥ 14 years were more likely to have bulimia nervosa compared with those < 14 years old. Patients with a sedentary lifestyle were less likely to have bulimia nervosa and binge eating disorders. In the nondysglycaemic group, those aged 14–18 years were more likely to have other eating disorders. Those with dysglycaemia were more likely to have binge eating disorders than those in the nondysglycaemic group (OR = 2.1, 95% CI: 1.3–3.3; P = 0.002) after adjusting for possible confounders. Conclusions: Adolescents with dysglycaemia had higher prevalence of eating disorders compared with their nondysglycaemic peers. Screening for eating disorders is recommended among adolescents to secure early detection and subsequent intervention.


Author(s):  
Susan McElroy ◽  
Anna I. Guerdjikova ◽  
Nicole Mori ◽  
Paul E. Keck

This chapter addresses the pharmacotherapy of the eating disorders (EDs). Many persons with EDs receive pharmacotherapy, but pharmacotherapy research for EDs has lagged behind that for other major mental disorders. This chapter first provides a brief rationale for using medications in the treatment of EDs. It then reviews the data supporting the effectiveness of specific medications or medication classes in treating patients with anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), and other potentially important EDs, such as night eating syndrome (NES). It concludes by summarizing these data and suggesting future areas for research in the pharmacotherapy of EDs.


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