scholarly journals Functional changes of visual cortex in pre- and post- operative intermittent exotropia patients: study protocol for a non-randomized case-control clinical trial

Author(s):  
Yanan Guo ◽  
Jing Fu ◽  
Jie Hong ◽  
Zhaohui Liu ◽  
Xueying He

Introduction: Intermittent exotropia (IXT) is the most common type of divergent squint. IXT is primarily a cortical neurologic dysfunction disorder, occurring as a result of insufficient maintaining of sensory and motor fusion. Recent reports have demonstrated the relationship between IXT and visual cortical impairment. We plan to assess blood oxygen level-dependent (BOLD)- functional magnetic resonance imaging (fMRI) in IXT patients during the pre-and post- operation follow-ups to evaluate the functional changes of the visual cortex. Methods and analysis: A total of 90 Chinese subjects will be recruited, and the age is between 18 and 60 years old. The subjects include the Surgical treatment (ST) group (45 IXT subjects who will perform surgery) and the Healthy control (HC) group (45 age - and sex - and education matched healthy volunteers). The assessments include the following aspects: general ophthalmic, optometry, binocular vision test, Newcastle Control Score (NCS), and fMRI. Each subject completes the rest-state BOLD-fMRI, and the sequences include echo planar imaging (EPI) pulse and 3-dimensional brain volume (3D-BRAVO) to acquire high-resolution images. The follow-up schedule is 6 and 12months after the surgery. The primary outcome will be determined by cortex changes in BOLD-fMRI in ST group before and after the surgery. We also compare the HC group with the pre-operation subjects in the ST group. The secondary outcomes are changes of strabismus examinations, binocular visual function examinations, and NCS. Ethics and dissemination: Ethical approval has been obtained from the Medical Ethics Committee of the Beijing Tongren Hospital. We plan to publish the results of this study in a peer-reviewed journal article. Trial registration number: ChiCTR2100048852 Keywords: Intermittent exotropia, Functional magnetic resonance imaging, Fusion function, Strabismus, Visual cortex

1996 ◽  
Vol 40 (3) ◽  
pp. 535-535 ◽  
Author(s):  
Philipp Joeri ◽  
Thierry Huisman ◽  
Dimitri Ekatodramis ◽  
Thomas Loenneker ◽  
Helmut Rumpel ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document