scholarly journals Impact of inspiratory vs expiratory incentive spirometry on obstructive, restrictive, and mixed ventilatory impairments: Study protocol. Effect of incentive spirometry on respiratory impairments.

2021 ◽  
Author(s):  
Eniola Oladejo Awolola ◽  
Sonill Sooknunan Maharaj
Keyword(s):  
Bronchial Asthma ◽  
Study Data ◽  
The Body ◽  
University Teaching ◽  
Placebo Control ◽  
State University ◽  
Asthma Patients ◽  
Interferential Therapy ◽  
Double Blinded ◽  
Incentive Spirometry

Background: Interferential therapy (IFT) is the application of two medium frequency currents to the skin to stimulate and activate different systems in the body using specific frequencies and frequency ranges. IFT aims to reduce myalgia in the chest and upper back, reduce muscular fatigue and induce mucus expectoration. This study is designed to test the efficacy of IFT on asthma patients recently exposed to SARS-CoV-2 virus. Methods: Twenty-eight (28) patients aged 18 and above with bronchial Asthma attending the respiratory clinic at the Lagos State University Teaching Hospital, Ikeja (LASUTH) will be assessed for the study eligibility. The study design will be a double-blinded, randomized control trial with two intervention groups and two parallel placebo control groups. IFT will be administered as an intervention to asthma patients with and without a history of COVID-19 exposure for 20 minutes. Six continuous outcome variables at different points will be utilized as an outcome measure. Selected Baseline Pulmonary Function Test (PFT) and Cardiopulmonary Variables (CVS) will be assessed on entry into the study, Quality of life and asthma control will be evaluated every two (2) weeks of the study. Data obtained will be analyzed using descriptive and inferential statistics of repeated ANOVA; P<0.05. Discussion: The study outcome will compare the efficacy of IFT on Bronchial Asthma patients with Post COVID-19 exposure, identify the relationship between the Intervention on Asthma patients with or without COVID-19 exposure.

scholarly journals Comparative efficacy of interferential therapy, bronchodilators, and body positioning on asthma control and quality of life of patients with bronchial asthma: Study protocol

2021 ◽  
Author(s):  
Eniola Awolola Oladejo ◽  
Sonill Maharaj Sooknunan
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Body Position ◽  
Study Data ◽  
The Body ◽  
University Teaching ◽  
Placebo Control ◽  
Interferential Therapy

AbstractBackgroundInterferential therapy (IFT) is the application of two medium frequency currents to the skin to stimulate and activate different systems in the body using specific frequencies and frequency ranges. IFT aims to reduce myalgia in the chest and upper back, reduce muscular fatigue and induce mucus expectoration. This study is designed to compare the efficacy of IFT on asthma control and quality of life of asthma patients pre-and post-administration of bronchodilators and determine the most influential body position in its application.MethodsForty-eight (48) patients aged 18 years and above with bronchial Asthma attending the respiratory clinic at the Lagos State University Teaching Hospital, Ikeja (LASUTH) will be assessed for the study eligibility. The study design will be a double-blinded, randomized control trial with four intervention groups and four parallel placebo control groups. IFT will be administered as an intervention to patients on short and long-acting bronchodilators in an assigned fundamental body position for 20 minutes. Six continuous outcome variables at different points will be utilized as an outcome measure. Baseline Pulmonary Function Test (PFT) will be assessed on entry into the study, Quality of life and asthma control will be evaluated every two (2) weeks of the study. Data obtained will be analyzed using descriptive and inferential statistics of repeated ANOVA; P<0.05.DiscussionThe study outcome will compare the efficacy of IFT on Bronchial Asthma, identify its effect in different body positions, and compare the relationship between its application and the bronchodilator medication frequently used by the patients.Trial Registrationhttps://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=10942:PACTR202005807526130

scholarly journals EFFICACY OF INTERFERENTIAL THERAPY ON SELECTED CARDIOPULMONARY PARAMETERS OF ASTHMATIC PATIENTS WITH POST COVID19 EXPOSURE: STUDY PROTOCOL

2021 ◽  
Author(s):  
Eniola Awolola
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Muscle Relaxation ◽  
Study Data ◽  
The Body ◽  
Smooth Muscle Relaxation ◽  
Asthmatic Patients ◽  
Asthma Patients ◽  
Interferential Therapy

Background: Interferential therapy (IFT) is the application of two medium frequency currents to the skin to stimulate and activate different systems in the body using specific frequencies and frequency ranges. IFT in the thoracic region aims to reduce myalgia in the chest and upper back, reduce muscular fatigue and induce mucus expectoration. This study is designed to test the efficacy of IFT on asthma patients recently exposed to SARS-CoV-2 virus.Methods: IFT will be administered as an intervention to 28 asthma patients with and without a history of COVID-19 exposure for 20 minutes. Six continuous outcome variables at different points will be utilized as an outcome measure. Selected Baseline Pulmonary Function Test (PFT) and Cardiopulmonary Variables (CVS) will be assessed on entry into the study, Quality of life and asthma control will be evaluated every two (2) weeks of the study. Data obtained will be analyzed using descriptive and inferential statistics of repeated ANOVA; P&lt;0.05. Discussion: The study outcome will compare the efficacy of IFT on Bronchial Asthma patients with Post COVID-19 exposure, identify the relationship between the Intervention on Asthma patients with or without COVID-19 exposure.Contribution of Paper: Asthma control in the SARS-CoV-2 virus is still unclear, this study aims to evaluate the effect of airway smooth muscle relaxation induced by IFT on the possible long-term manifestations of SARS-CoV-2 virus on asthma control, and quality of life of asthma patients. This study will add to the existing knowledge on the management of the severe acute respiratory syndrome.

scholarly journals Advantage of the regenerative potentials of the periosteum especially in children, Oghara experience: A case series

2020 ◽  
Vol 8 (2) ◽  
pp. 124-132
Author(s):  
R.E.T. Enemudo ◽  
D.O. Odatuwa-Omagbemi ◽  
E.O. Edomwonyi ◽  
A.T. Obumse ◽  
E.O. Akpojevwe
Keyword(s):  
Distal Tibia ◽  
Bone Tumour ◽  
Case Series ◽  
Cost Effective ◽  
Bone Defects ◽  
The Body ◽  
University Teaching ◽  
Clinical Use ◽  
State University ◽  
Body Of Knowledge

The periosteum is a composite tissue comprising an outer protective fibrovascular layer and an inner cambium regenerative pluripotent layer. The regenerative function of periosteum has been put to clinical use by dental surgeons to manage alveolar ridge reduction and by tissue engineers to produce autologous micrograft and collagen used to manage complex wounds and scars. The essence of this study is to add to the body of knowledge on clinical use of periosteum to treat bone defects from the orthopaedic perspective. We highlight a case series to demonstrate the use of periosteum in managing bone defects caused by benign bone tumour, chronic osteomyelitis, tibial hemimelia and traumatic bone loss of the distal tibia in Delta State University Teaching Hospital, Oghara. Treatment of bone defects by this means is cost effective and the outcome is very satisfactory. Key words:  Periosteum, mesenchymal stem cells, bone defects, distraction histiogenesis.

INTERMITTENT HYPOXIC THERAPY IN THE TREATMENT OF BRONCHIAL ASTHMA PATIENTS WITH VARIOUS CHRONOTYPES

2021 ◽  
pp. 125-135
Author(s):  
A.B. Ivanov ◽  
I.Kh. Borukaeva ◽  
Z.Kh. Abazova ◽  
K.Yu. Shkhagumov ◽  
A.A. Molov
Keyword(s):  
Circadian Rhythms ◽  
Bronchial Asthma ◽  
Respiratory System ◽  
Individual Characteristics ◽  
The Body ◽  
Antioxidant Systems ◽  
Adaptation To Hypoxia ◽  
Oxygen Intake ◽  
Compensatory Mechanisms ◽  
Asthma Patients

The purpose of the paper is to identify the efficacy of normobaric interval hypoxic therapy in the treatment and rehabilitation of bronchial asthma patients, taking into account their individual characteristics of circadian rhythms. Materials and Methods. The authors examined the indicators of the functional respiratory system and oxygen regimes of the body, lipid peroxidation and antioxidant system and spirometric data in 145 patients with bronchial asthma. Patients’ chronotypes were also determined. Bronchodilators were used to carry out individual peak flowmetry and to determine airway sensitivity, which made it possible to reveal the bronchial tree reactivity. In order to identify individual intolerance to the hypoxic factor and to select the optimal oxygen level in the gas mixture all patients underwent a hypoxic test before the hypoxic therapy. Results. The results obtained showed that morning hypoxic therapy sessions had the greatest effect in patients with bronchial asthma. A decrease in the malondialdehyde level indicated a decrease in lipid and protein peroxidation. An increase in the blood glutathione peroxidase and superoxide dismutase rates showed an increase in antioxidant protection. Intermittent normobaric hypoxic therapy improved the body oxygen supply during its transport and contributed to oxygen intake and a hypoxic decrease in the bronchopulmonary system. The hypoxic mixture was chosen individually, taking into account patient’s chronotype, in order to induce the subcompensated hypoxia. However, the morning hours turned out to be optimal for the greatest mobilization of compensatory mechanisms and adaptation to hypoxia in most patients. Conclusion. We consider it necessary to adjust recommendations for the use of intermittent normobaric hypoxic therapy in bronchial asthma patients, taking into account their circadian rhythms, and to recommend conducting hypoxic therapy in the morning and in the afternoon (from 8 a.m. to 3 p.m.). Keywords: bronchial asthma, intermittent hypoxytherapy, chronotypes, functional respiratory system, prooxidant and antioxidant systems. Цель – определение эффективности использования нормобарической интервальной гипокситерапии в лечении и реабилитации пациентов с бронхиальной астмой с учетом индивидуальных особенностей суточных ритмов. Материалы и методы. У 145 пациентов с бронхиальной астмой анализировались показатели функциональной системы дыхания и кислородных режимов организма, перекисного окисления липидов и антиоксидантной системы, спирометрические данные; определялись хронотипы больных. С помощью пробы с бронходилятатором проводилась индивидуальная пикфлоуметрия и определялась чувствительность дыхательных путей, что позволило выявить степень реактивности бронхиального дерева. Перед гипокситерапией всем больным проводился гипоксический тест с целью выявления индивидуальной непереносимости гипоксического фактора и подбора оптимального содержания кислорода в газовой смеси. Результаты. Полученные результаты показали, что наибольшим эффектом обладают утренние сеансы гипокситерапии. Понижение уровня малонового диальдегида явилось показателем снижения перекисного окисления липидов и белков. Рост уровня глютатионпероксидазы и супероксиддисмутазы в крови свидетельствовал об усилении антиоксидантной защиты. Интервальная нормобарическая гипокситерапия улучшила обеспечение организма кислородом на этапах его транспортировки и способствовала повышению потребления кислорода тканями, а также снижению степени гипоксии в бронхолегочной системе. Несмотря на то, что гипоксическая смесь подбиралась пациентам индивидуально с учетом их хронотипов и с целью вызвать развитие субкомпенсированной гипоксии, оптимальными для наибольшей мобилизации компенсаторных механизмов и адаптации к гипоксии оказались утренние часы. Выводы. Считаем необходимым внести коррективы в рекомендации по использованию интервальной нормобарической гипокситерапии у пациентов с бронхиальной астмой с учетом суточных ритмов и рекомендовать проведение курсов гипокситерапии в утренние и дневные часы – в промежутке с 8 до 15 ч. Ключевые слова: бронхиальная астма, интервальная гипокситерапия, хронотипы, функциональная система дыхания, прооксидантная и антиоксидантная системы.

scholarly journals Antioxidant Status of Breast, Cervical and Ovarian Cancer Patients at Various Menopausal Stages in Lagos State, Nigeria

2019 ◽  
pp. 1-7
Author(s):  
E. I. Ayo ◽  
M. F. Asaolu ◽  
O. G. Oyebanji ◽  
I. Akinlua ◽  
A. A. Sonuga
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Teaching Hospital ◽  
Antioxidant Status ◽  
The Body ◽  
University Teaching ◽  
State University ◽  
Control Groups ◽  
Control Subjects ◽  
Lagos State

Cancer is a collection of diseases which involves the abnormal growth of cells with the potential to invade or spread to other parts of the body. The aim of this study is to access the antioxidant status of women with female predominant cancer (breast, cervical and ovarian) in relationship with their menopausal stages. Blood samples were collected from 180 freshly diagnosed female patients of breast, cervical and ovarian cancer at Lagos State University Teaching Hospital, Idi- Araba, Mushin, Lagos and Lagos State University Teaching Hospital Ikeja, Lagos and 60 relatively healthy subjects at different menopausal stages. Serum catalase (CAT), Superoxide dismutase (SOD) activites, Reduced Glutathione (GSH), Vitamin C and E concentrations were evaluated in subject’s blood sample using standard established methods. The results obtained were subjected to statistical analysis (p<0.05). However, the results of the female cancer patients at each menopausal stage were compared to premenopausal, menopausal and postmenopausal control groups, while the results obtained from the menopausal and postmenopausal control subjects were compared to the premenopausal control subjects. There was significant decrease (p<0.05) in the activities of CAT, SOD and in the concentrations of GSH, Vitamins C and E in all the menopausal stages when compared to the control groups. However, MDA concentrations showed significant increase (p<0.05) in all the menopausal stages in comparison to the corresponding control groups. These findings suggest that cancer patients might be at risk from oxidative cell damage. Therefore, further research is required in this field with a view of improving the management of cancers predominant in females.

scholarly journals Spectrum of urological procedures in Yobe State University Teaching Hospital: an initial experience in a young west African hospital

2021 ◽  
Vol 8 (2) ◽  
pp. 455
Author(s):  
Usman Mohammed Tela ◽  
Rufai Mainasara
Keyword(s):  
Teaching Hospital ◽  
Day Surgery ◽  
Study Data ◽  
University Teaching ◽  
Indications For Surgery ◽  
State University ◽  
Urine Retention ◽  
Prostate Hyperplasia ◽  
Female Ratio ◽  
Urological Procedures

Background: In auditing the surgical procedures of a hospital, services rendered to patients are reviewed using the data generated from the procedures, hence the outcome is used as a framework for improvement in future and capacity building. Objectives of the study were to analyze the indications for Urological procedures with the procedures performed at Yobe State University Teaching Hospital (YSUTH) and share our experience, with recommendation for future improvement.Methods: Retrospective hospital-based study on patients who had urological procedures done in YSUTH between March 2018 to April 2020. Urology patients that have not undergone any urological procedure were excluded from the study. Data obtained from the records in the operation theatre, emergency unit and medical record department of the hospital.Results: There were 185 patients with indications for surgery, constituting 41.0% of all general surgery patients. Male to female ratio was 8.7:1 and the median age range was 70-79 years. A sum of 212 urology procedures performed. Benign prostate hyperplasia (BPH) and prostatectomies were the commonest diagnoses and elective procedures respectively, while urethral stricture and bladder cancer were the 2nd and 3rd diagnose respectively. Urethral catheterization for urine retention in BPH was the commonest emergency procedure. Cystoscopy was the commonest day case and the commonest among endo-urology procedures.Conclusions: BPH, followed by urethral strictures and bladder cancers were the commonest diagnoses and indications for surgery. Urine retention in BPH is the commonest emergency requiring urthral catherization. Creation of dedicated day surgery unit and employment of permanentt consultant urologists and more  health personnels relevant to urology, will improve the quality and quantity of services rendered.  

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

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