scholarly journals Extreme value analysis of intracellular cargo transport by motor proteins

2021 ◽  
Author(s):  
Takuma Naoi ◽  
Yuki Kagawa ◽  
Kimiko Nagino ◽  
Shinsuke Niwa ◽  
Kumiko Hayashi

In the long axon of a neuron, cargo transport between the cell body and terminal synaptic region are mainly supported by the motor proteins kinesin and dynein, which are nano-sized drivers. Synaptic materials packed as cargos are anterogradely transported to the synaptic region by kinesin, whereas materials accumulated at the axon terminals are returned to the cell body by dynein. Extreme value analysis, typically used for disaster prevention in our society, was applied to analyze the velocity of kinesin and dynein nanosized drivers to disclose their physical properties in living cells.

2014 ◽  
Vol 58 (3) ◽  
pp. 193-207 ◽  
Author(s):  
C Photiadou ◽  
MR Jones ◽  
D Keellings ◽  
CF Dewes

Extremes ◽  
2021 ◽  
Author(s):  
Laura Fee Schneider ◽  
Andrea Krajina ◽  
Tatyana Krivobokova

AbstractThreshold selection plays a key role in various aspects of statistical inference of rare events. In this work, two new threshold selection methods are introduced. The first approach measures the fit of the exponential approximation above a threshold and achieves good performance in small samples. The second method smoothly estimates the asymptotic mean squared error of the Hill estimator and performs consistently well over a wide range of processes. Both methods are analyzed theoretically, compared to existing procedures in an extensive simulation study and applied to a dataset of financial losses, where the underlying extreme value index is assumed to vary over time.


2021 ◽  
Author(s):  
Jeremy Rohmer ◽  
Rodrigo Pedreros ◽  
Yann Krien

<p>To estimate return levels of wave heights (Hs) induced by tropical cyclones at the coast, a commonly-used approach is to (1) randomly generate a large number of synthetic cyclone events (typically >1,000); (2) numerically simulate the corresponding Hs over the whole domain of interest; (3) extract the Hs values at the desired location at the coast and (4) perform the local extreme value analysis (EVA) to derive the corresponding return level. Step 2 is however very constraining because it often involves a numerical hydrodynamic simulator that can be prohibitive to run: this might limit the number of results to perform the local EVA (typically to several hundreds). In this communication, we propose a spatial stochastic simulation procedure to increase the database size of numerical results with synthetic maps of Hs that are stochastically generated. To do so, we propose to rely on a data-driven dimensionality-reduction method, either unsupervised (Principal Component Analysis) or supervised (Partial Least Squares Regression), that is trained with a limited number of pre-existing numerically simulated Hs maps. The procedure is applied to the Guadeloupe island and results are compared to the commonly-used approach applied to a large database of Hs values computed for nearly 2,000 synthetic cyclones (representative of 3,200 years – Krien et al., NHESS, 2015). When using only a hundred of cyclones, we show that the estimates of the 100-year return levels can be achieved with a mean absolute percentage error (derived from a bootstrap-based procedure) ranging between 5 and 15% around the coasts while keeping the width of the 95% confidence interval of the same order of magnitude than the one using the full database. Without synthetic Hs maps augmentation, the error and confidence interval width are both increased by nearly 100%. A careful attention is paid to the tuning of the approach by testing the sensitivity to the spatial domain size, the information loss due to data compression, and the number of cyclones. This study has been carried within the Carib-Coast INTERREG project (https://www.interreg-caraibes.fr/carib-coast).</p>


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