scholarly journals The gift of gab: probing the limits of dynamic concentration-sensing across a network of communicating cells

2019 ◽  
Author(s):  
Mohammadreza Bahadorian ◽  
Christoph Zechner ◽  
Carl Modes

Many systems in biology and beyond employ collaborative, collective communication strategies for improved efficiency and adaptive benefit. One such paradigm of particular interest is the community estimation of a dynamic signal, when, for example, an epithelial tissue of cells must decide whether to react to a given dynamic external concentration of stress signaling molecules. At the level of dynamic cellular communication, however, it remains unknown what effect, if any, arises from communication beyond the mean field level. What are the limits and benefits to communication across a network of neighbor interactions? What is the role of Poissonian vs. super Poissonian dynamics in such a setting? How does the particular topology of connections impact the collective estimation and that of the individual participating cells? In this letter we construct a robust and general framework of signal estimation over continuous time Markov chains in order to address and answer these questions. Our results show that in the case of Possonian estimators, the communication solely enhances convergence speed of the Mean Squared Error (MSE) of the estimators to their steady-state values while leaving these values unchanged. However, in the super-Poissonian regime, MSE of estimators significantly decreases by increasing the number of neighbors. Surprisingly, in this case, the clustering coefficient of an estimator does not enhance its MSE while reducing total MSE of the population.

2020 ◽  
Author(s):  
Jon Saenz ◽  
Sheila Carreno-Madinabeitia ◽  
Ganix Esnaola ◽  
Santos J. González-Rojí ◽  
Gabriel Ibarra-Berastegi ◽  
...  

<p align="justify">A new diagram is proposed for the verification of vector quantities generated by individual or multiple models against a set of observations. It has been designed with the idea of extending the Taylor diagram to two-dimensional vector such as currents, wind velocity, or horizontal fluxes of water vapour, salinity, energy and other geophysical variables. The diagram is based on <span>a principal component</span> analysis of the two-dimensional structure of the mean squared error matrix between model and observations. This matrix is separated in two parts corresponding to the bias and the relative rotation of the empirical orthogonal functions of the data. We test the performance of this new diagram identifying the differences amongst <span>a</span> reference dataset and different model outputs using examples wind velocities, current, vertically integrated moisture transport and wave energy flux time series. An alternative setup is also <span>proposed</span> with an application to the time-averaged spatial field of surface wind velocity in the Northern and Southern Hemispheres according to different reanalyses and realizations of an ensemble of CMIP5 models. The examples of the use of the Sailor diagram show that it is a tool which helps identifying errors due to the bias or the orientation of the simulated vector time series or fields. An implementation of the algorithm in form of an R package (sailoR) is already publicly available from the CRAN repository, and besides the ability to plot the individual components of the error matrix, functions in the package also allow to easily retrieve the individual components of the mean squared error.</p>


1998 ◽  
Vol 167 ◽  
pp. 406-414
Author(s):  
N. Seehafer

AbstractFilaments are a global phenomenon and their formation, structure and dynamics are determined by magnetic fields. So they are an important signature of the solar magnetism. The central mechanism in traditional mean-field dynamo theory is the alpha effect and it is a major result of this theory that the presence of kinetic or magnetic helicities is at least favourable for the effect. Recent studies of the magnetohydrodynamic equations by means of numerical bifurcation-analysis techniques have confirmed the decisive role of helicity for a dynamo effect. The alpha effect corresponds to the simultaneous generation of magnetic helicities in the mean field and in the fluctuations, the generation rates being equal in magnitude and opposite in sign. In the case of statistically stationary and homogeneous fluctuations, in particular, the alpha effect can increase the energy in the mean magnetic field only under the condition that also magnetic helicity is accumulated there. Generally, the two helicities generated by the alpha effect, that in the mean field and that in the fluctuations, have either to be dissipated in the generation region or to be transported out of this region. The latter may lead to the appearance of helicity in the atmosphere, in particular in filaments, and thus provide valuable information on dynamo processes inaccessible to in situ measurements.


2011 ◽  
Vol 60 (2) ◽  
pp. 248-255 ◽  
Author(s):  
Sangmun Shin ◽  
Funda Samanlioglu ◽  
Byung Rae Cho ◽  
Margaret M. Wiecek

2018 ◽  
Vol 10 (12) ◽  
pp. 4863 ◽  
Author(s):  
Chao Huang ◽  
Longpeng Cao ◽  
Nanxin Peng ◽  
Sijia Li ◽  
Jing Zhang ◽  
...  

Photovoltaic (PV) modules convert renewable and sustainable solar energy into electricity. However, the uncertainty of PV power production brings challenges for the grid operation. To facilitate the management and scheduling of PV power plants, forecasting is an essential technique. In this paper, a robust multilayer perception (MLP) neural network was developed for day-ahead forecasting of hourly PV power. A generic MLP is usually trained by minimizing the mean squared loss. The mean squared error is sensitive to a few particularly large errors that can lead to a poor estimator. To tackle the problem, the pseudo-Huber loss function, which combines the best properties of squared loss and absolute loss, was adopted in this paper. The effectiveness and efficiency of the proposed method was verified by benchmarking against a generic MLP network with real PV data. Numerical experiments illustrated that the proposed method performed better than the generic MLP network in terms of root mean squared error (RMSE) and mean absolute error (MAE).


2016 ◽  
Vol 5 (1) ◽  
pp. 39 ◽  
Author(s):  
Abbas Najim Salman ◽  
Maymona Ameen

<p>This paper is concerned with minimax shrinkage estimator using double stage shrinkage technique for lowering the mean squared error, intended for estimate the shape parameter (a) of Generalized Rayleigh distribution in a region (R) around available prior knowledge (a<sub>0</sub>) about the actual value (a) as initial estimate in case when the scale parameter (l) is known .</p><p>In situation where the experimentations are time consuming or very costly, a double stage procedure can be used to reduce the expected sample size needed to obtain the estimator.</p><p>The proposed estimator is shown to have smaller mean squared error for certain choice of the shrinkage weight factor y(<strong>×</strong>) and suitable region R.</p><p>Expressions for Bias, Mean squared error (MSE), Expected sample size [E (n/a, R)], Expected sample size proportion [E(n/a,R)/n], probability for avoiding the second sample and percentage of overall sample saved  for the proposed estimator are derived.</p><p>Numerical results and conclusions for the expressions mentioned above were displayed when the consider estimator are testimator of level of significanceD.</p><p>Comparisons with the minimax estimator and with the most recent studies were made to shown the effectiveness of the proposed estimator.</p>


2020 ◽  
Vol 2020 ◽  
pp. 1-22
Author(s):  
Byung-Kwon Son ◽  
Do-Jin An ◽  
Joon-Ho Lee

In this paper, a passive localization of the emitter using noisy angle-of-arrival (AOA) measurements, called Brown DWLS (Distance Weighted Least Squares) algorithm, is considered. The accuracy of AOA-based localization is quantified by the mean-squared error. Various estimates of the AOA-localization algorithm have been derived (Doğançay and Hmam, 2008). Explicit expression of the location estimate of the previous study is used to get an analytic expression of the mean-squared error (MSE) of one of the various estimates. To validate the derived expression, we compare the MSE from the Monte Carlo simulation with the analytically derived MSE.


2017 ◽  
Vol 28 (11) ◽  
pp. 1750133 ◽  
Author(s):  
Krzysztof Kułakowski ◽  
Piotr Gronek ◽  
Alfio Borzì

Recently, a computational model has been proposed of the social integration, as described in sociological terms by Blau. In this model, actors praise or critique each other, and these actions influence their social status and raise negative or positive emotions. The role of a self-deprecating strategy of actors with high social status has also been discussed there. Here, we develop a mean field approach, where the active and passive roles (praising and being praised, etc.) are decoupled. The phase transition from friendly to hostile emotions has been reproduced, similarly to the previously applied purely computational approach. For both phases, we investigate the time dependence of the distribution of social status. There we observe a diffusive spread, which — after some transient time — appears to be limited from below or from above, depending on the phase. As a consequence, the mean status flows.


Author(s):  
Mary Jeba N

The study intended to find out any relationship between aggressive behavior and emotional maturity of adolescents. Aggressive behavior is the reactionary and impulsive behaviour. The role of education is the modification of behaviour of the individual. So, school has a great role in mending the behaviour of the students. Moral education and mediation can be given to students. This may help them to get rid of the aggressive behaviour. The investigator used the mean, standard deviation, t-test and ANOVA (analysis of variance) to analyze the data and results were tabulated. The adolescent students show more aggressive behaviour than emotional maturity.


2009 ◽  
Vol 106 (3) ◽  
pp. 975-983 ◽  
Author(s):  
Mark Burnley

To determine whether the asymptote of the torque-duration relationship (critical torque) could be estimated from the torque measured at the end of a series of maximal voluntary contractions (MVCs) of the quadriceps, eight healthy men performed eight laboratory tests. Following familiarization, subjects performed two tests in which they were required to perform 60 isometric MVCs over a period of 5 min (3 s contraction, 2 s rest), and five tests involving intermittent isometric contractions at ∼35–60% MVC, each performed to task failure. Critical torque was determined using linear regression of the torque impulse and contraction time during the submaximal tests, and the end-test torque during the MVCs was calculated from the mean of the last six contractions of the test. During the MVCs voluntary torque declined from 263.9 ± 44.6 to 77.8 ± 17.8 N·m. The end-test torque was not different from the critical torque (77.9 ± 15.9 N·m; 95% paired-sample confidence interval, −6.5 to 6.2 N·m). The root mean squared error of the estimation of critical torque from the end-test torque was 7.1 N·m. Twitch interpolation showed that voluntary activation declined from 90.9 ± 6.5% to 66.9 ± 13.1% ( P < 0.001), and the potentiated doublet response declined from 97.7 ± 23.0 to 46.9 ± 6.7 N·m ( P < 0.001) during the MVCs, indicating the development of both central and peripheral fatigue. These data indicate that fatigue during 5 min of intermittent isometric MVCs of the quadriceps leads to an end-test torque that closely approximates the critical torque.


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