scholarly journals Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 ◽  
Vol 8 (17) ◽  
pp. 2008-2021 ◽  
Author(s):  
E Y Lee ◽  
N Hu ◽  
S S Yuan ◽  
L A Cox ◽  
A Bradley ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Dual Roles ◽  
Neuron Differentiation ◽  
Cycle Regulation

scholarly journals The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation

Oncogene ◽  
2000 ◽  
Vol 19 (32) ◽  
pp. 3598-3608 ◽  
Author(s):  
Laura Hertel ◽  
Sandra Rolle ◽  
Marco De Andrea ◽  
Barbara Azzimonti ◽  
Raffaella Osello ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Cycle Regulation

scholarly journals APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

2016 ◽  
Vol 36 (5) ◽  
Author(s):  
Ajeena Ramanujan ◽  
Swati Tiwari
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Alternative Pathway ◽  
Retinoblastoma Protein ◽  
S Phase ◽  
Anaphase Promoting Complex ◽  
Anti Cancer ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Cycle Regulation

The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G1-phase of the cell cycle whereas pRB keeps a check on proliferation by inhibiting transition to the S-phase. APC/C and pRB interact with each other via the co-activator of APC/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism. Both are also targeted by transforming viruses. We discuss recent advances in our understanding of the involvement of APC/C and pRB in cell cycle based decisions and how these insights will be useful for development of anti-cancer and anti-viral drugs.

The retinoblastoma protein and cell cycle regulation

1992 ◽  
Vol 8 (5) ◽  
pp. 180-185 ◽  
Author(s):  
P.A. Hamel ◽  
B.L. Gallie ◽  
R.A. Phillips
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Regulation ◽  
Retinoblastoma Protein ◽  
Cycle Regulation
Sign in / Sign up

Export Citation Format

Share Document