Identification of the Stage of the Life Cycle of the Scientific Direction with the Help of the Research Front

Analyzing Research Fronts in Medical Informatics Field Based on Topic Model and Life Cycle Theory

10.21203/rs.2.22157/v1 ◽

2020 ◽

Author(s):

Jia Feng ◽

Xiaomin Mu ◽

Fangfang Li ◽

Yong Shen ◽

Wei Wang ◽

...

Keyword(s):

Life Cycle ◽

Medical Informatics ◽

Language Processing ◽

Latent Dirichlet Allocation ◽

Topic Model ◽

Research Front ◽

Research Topics ◽

Life Cycle Theory ◽

Research Activities ◽

Research Fronts

Abstract Background: Medical informatics (MI) is a multidisciplinary field in which researchers pursue scientific exploration, problem-solving, and decision-making to facilitate the effective use of biomedical data, information and knowledge for the improvement of human health. The purpose of this study is to identify research fronts in the field of MI and ultimately elucidate research activities and trends in this field. Methods: This study used topic model to identify research topics in the field of MI based on the latent Dirichlet allocation method (LDA). And the topic cloud is utilized to visualize the research topics. For identifying the research front topics, we proposed the indicators of identifying research front topics. In addition, we investigated how front topics change over time, and divided them into five categories based on the life cycle theory. Results: The data were collected from 35981 published journal abstracts between 2007 and 2016. In the topic distribution of MI, we found that the scope of MI related research has become increasingly interdisciplinary, particular for medical data analysis. Also, in the analysis of research fronts of MI, we found that the use of natural language processing and medical text knowledge extraction play an essential role for systematic analysis and indexing of the underlying semantic contents. Conclusions: By categorizing the research fronts, the results shows that there are twelve growing, five stable and two declining research fronts. We hope that this work will facilitate greater exploration of the method of identifying the research fronts. Moreover, the findings of this study provide an insight on the research fronts and trends in MI.

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Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100156791 ◽

1989 ◽

Vol 47 ◽

pp. 962-963

Author(s):

Betty Ruth Jones ◽

Steve Chi-Tang Pan

Keyword(s):

Nervous System ◽

Life Cycle ◽

Schistosoma Mansoni ◽

Snail Host ◽

Complex Life Cycle ◽

Rational Approach ◽

Effective Control ◽

The Social ◽

Social And Economic Development ◽

Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

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A freeze-fracture-etched study of the physarum polycephalum plasma membrane during early formation of the macroplasmodial stage

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100147570 ◽

1993 ◽

Vol 51 ◽

pp. 346-347

Author(s):

Randolph W. Taylor ◽

Henrie Treadwell

Keyword(s):

Plasma Membrane ◽

Life Cycle ◽

Growth Phase ◽

Filter Paper ◽

Physarum Polycephalum ◽

Freeze Fracture ◽

Petri Dish ◽

Wire Screen ◽

Wide Mouth ◽

Sterile Filter

The plasma membrane of the Slime Mold, Physarum polycephalum, process unique morphological distinctions at different stages of the life cycle. Investigations of the plasma membrane of P. polycephalum, particularly, the arrangements of the intramembranous particles has provided useful information concerning possible changes occurring in higher organisms. In this report Freeze-fracture-etched techniques were used to investigate 3 hours post-fusion of the macroplasmodia stage of the P. polycephalum plasma membrane.Microplasmodia of Physarum polycephalum (M3C), axenically maintained, were collected in mid-expotential growth phase by centrifugation. Aliquots of microplasmodia were spread in 3 cm circles with a wide mouth pipette onto sterile filter paper which was supported on a wire screen contained in a petri dish. The cells were starved for 2 hrs at 24°C. After starvation, the cells were feed semidefined medium supplemented with hemin and incubated at 24°C. Three hours after incubation, samples were collected randomly from the petri plates, placed in plancettes and frozen with a propane-nitrogen jet freezer.

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