Integrating Symmetric Nonnegative Matrix Factorization and Normalized Cut Spectral Clustering

Author(s):  
Zhichen Xia ◽  
Chris Ding
2020 ◽  
Vol 21 (S6) ◽  
Author(s):  
Yuanyuan Ma ◽  
Junmin Zhao ◽  
Yingjun Ma

Abstract Background With the rapid development of high-throughput technique, multiple heterogeneous omics data have been accumulated vastly (e.g., genomics, proteomics and metabolomics data). Integrating information from multiple sources or views is challenging to obtain a profound insight into the complicated relations among micro-organisms, nutrients and host environment. In this paper we propose a multi-view Hessian regularization based symmetric nonnegative matrix factorization algorithm (MHSNMF) for clustering heterogeneous microbiome data. Compared with many existing approaches, the advantages of MHSNMF lie in: (1) MHSNMF combines multiple Hessian regularization to leverage the high-order information from the same cohort of instances with multiple representations; (2) MHSNMF utilities the advantages of SNMF and naturally handles the complex relationship among microbiome samples; (3) uses the consensus matrix obtained by MHSNMF, we also design a novel approach to predict the classification of new microbiome samples. Results We conduct extensive experiments on two real-word datasets (Three-source dataset and Human Microbiome Plan dataset), the experimental results show that the proposed MHSNMF algorithm outperforms other baseline and state-of-the-art methods. Compared with other methods, MHSNMF achieves the best performance (accuracy: 95.28%, normalized mutual information: 91.79%) on microbiome data. It suggests the potential application of MHSNMF in microbiome data analysis. Conclusions Results show that the proposed MHSNMF algorithm can effectively combine the phylogenetic, transporter, and metabolic profiles into a unified paradigm to analyze the relationships among different microbiome samples. Furthermore, the proposed prediction method based on MHSNMF has been shown to be effective in judging the types of new microbiome samples.


Symmetry ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1187
Author(s):  
Peitao Wang ◽  
Zhaoshui He ◽  
Jun Lu ◽  
Beihai Tan ◽  
YuLei Bai ◽  
...  

Symmetric nonnegative matrix factorization (SNMF) approximates a symmetric nonnegative matrix by the product of a nonnegative low-rank matrix and its transpose. SNMF has been successfully used in many real-world applications such as clustering. In this paper, we propose an accelerated variant of the multiplicative update (MU) algorithm of He et al. designed to solve the SNMF problem. The accelerated algorithm is derived by using the extrapolation scheme of Nesterov and a restart strategy. The extrapolation scheme plays a leading role in accelerating the MU algorithm of He et al. and the restart strategy ensures that the objective function of SNMF is monotonically decreasing. We apply the accelerated algorithm to clustering problems and symmetric nonnegative tensor factorization (SNTF). The experiment results on both synthetic and real-world data show that it is more than four times faster than the MU algorithm of He et al. and performs favorably compared to recent state-of-the-art algorithms.


2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Qunyi Xie ◽  
Hongqing Zhu

Content-based image retrieval has recently become an important research topic and has been widely used for managing images from repertories. In this article, we address an efficient technique, called MNGS, which integrates multiview constrained nonnegative matrix factorization (NMF) and Gaussian mixture model- (GMM-) based spectral clustering for image retrieval. In the proposed methodology, the multiview NMF scheme provides competitive sparse representations of underlying images through decomposition of a similarity-preserving matrix that is formed by fusing multiple features from different visual aspects. In particular, the proposed method merges manifold constraints into the standard NMF objective function to impose an orthogonality constraint on the basis matrix and satisfy the structure preservation requirement of the coefficient matrix. To manipulate the clustering method on sparse representations, this paper has developed a GMM-based spectral clustering method in which the Gaussian components are regrouped in spectral space, which significantly improves the retrieval effectiveness. In this way, image retrieval of the whole database translates to a nearest-neighbour search in the cluster containing the query image. Simultaneously, this study investigates the proof of convergence of the objective function and the analysis of the computational complexity. Experimental results on three standard image datasets reveal the advantages that can be achieved with the proposed retrieval scheme.


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