The Madistor-A Magnetically Controlled Semiconductor Plasma Device

AbstractEfficient methods to achieve the safe decontamination of agricultural products are needed. Here, we investigated the decontamination of citrus fruits to test the antifungal potential of a novel non-thermal gas plasma apparatus, termed a roller conveyer plasma instrument. This instrument generates an atmospheric pressure dielectric barrier discharge (APDBP) plasma on a set of rollers. Penicillium venetum was spotted onto the surface of the fruit or pericarps, as well as an aluminium plate to act as a control, before performing the plasma treatment. The results showed that viable cell number of P. venetum decreased with a decimal reduction time (D value or estimated treatment time required to reduce viable cell number by 90%) of 0.967 min on the aluminium plate, 2.90 min and 1.88 min on the pericarps of ‘Kiyomi’ (Citrus unshiu × C. sinensis) and ‘Kawano-natsudaidai’ (C. natsudaidai) respectively, and 2.42 min on the surface of ‘Unshu-mikan’ (C. unshiu). These findings confirmed a fungicidal effect of the plasma not only on an abiotic surface (aluminium plate) but also on a biotic surface (citrus fruit). Further development of the instrument by combining sorting systems with the plasma device promises an efficient means of disinfecting citrus fruits during food processing.

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Quantifying erosion and retention of silicon carbide due to D plasma irradiation in a high-flux linear plasma device

Nuclear Materials and Energy ◽

10.1016/j.nme.2021.100939 ◽

2021 ◽

Vol 26 ◽

pp. 100939

Author(s):

G. Sinclair ◽

T. Abrams ◽

S. Bringuier ◽

D.M. Thomas ◽

L. Holland ◽

...

Keyword(s):

Silicon Carbide ◽

High Flux ◽

Plasma Irradiation ◽

Plasma Device ◽

Linear Plasma

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Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen

Scientific Reports ◽

10.1038/s41598-020-80512-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Lea Miebach ◽

Eric Freund ◽

Stefan Horn ◽

Felix Niessner ◽

Sanjeev Kumar Sagwal ◽

...

Keyword(s):

Cell Death ◽

Dendritic Cells ◽

Cancer Cells ◽

Treatment Time ◽

Plasma Source ◽

In Vivo Model ◽

Antitumor Effects ◽

Plasma Device

AbstractRecent research indicated the potential of cold physical plasma in cancer therapy. The plethora of plasma-derived reactive oxygen and nitrogen species (ROS/RNS) mediate diverse antitumor effects after eliciting oxidative stress in cancer cells. We aimed at exploiting this principle using a newly designed dual-jet neon plasma source (Vjet) to treat colorectal cancer cells. A treatment time-dependent ROS/RNS generation induced oxidation, growth retardation, and cell death within 3D tumor spheroids were found. In TUM-CAM, a semi in vivo model, the Vjet markedly reduced vascularized tumors' growth, but an increase of tumor cell immunogenicity or uptake by dendritic cells was not observed. By comparison, the argon-driven single jet kINPen, known to mediate anticancer effects in vitro, in vivo, and in patients, generated less ROS/RNS and terminal cell death in spheroids. In the TUM-CAM model, however, the kINPen was equivalently effective and induced a stronger expression of immunogenic cancer cell death (ICD) markers, leading to increased phagocytosis of kINPen but not Vjet plasma-treated tumor cells by dendritic cells. Moreover, the Vjet was characterized according to the requirements of the DIN-SPEC 91315. Our results highlight the plasma device-specific action on cancer cells for evaluating optimal discharges for plasma cancer treatment.

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Low-Temperature Plasma as an Approach for Inhibiting a Multi-Species Cariogenic Biofilm

Applied Sciences ◽

10.3390/app11020570 ◽

2021 ◽

Vol 11 (2) ◽

pp. 570

Author(s):

Leandro W. Figueira ◽

Beatriz H. D. Panariello ◽

Cristiane Y. Koga-Ito ◽

Simone Duarte

Keyword(s):

Low Temperature ◽

Laser Scanning ◽

Single Species ◽

Laser Scanning Microscopy ◽

Confocal Laser ◽

Low Temperature Plasma ◽

Temperature Plasma ◽

Plasma Device ◽

Negative Controls ◽

Promising Source

This study aimed to determine how low-temperature plasma (LTP) treatment affects single- and multi-species biofilms formed by Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii formed on hydroxyapatite discs. LTP was produced by argon gas using the kINPen09™ (Leibniz Institute for Plasma Science and Technology, INP, Greifswald, Germany). Biofilms were treated at a 10 mm distance from the nozzle of the plasma device to the surface of the biofilm per 30 s, 60 s, and 120 s. A 0.89% saline solution and a 0.12% chlorhexidine solution were used as negative and positive controls, respectively. Argon flow at three exposure times (30 s, 60 s, and 120 s) was also used as control. Biofilm viability was analyzed by colony-forming units (CFU) recovery and confocal laser scanning microscopy. Multispecies biofilms presented a reduction in viability (log10 CFU/mL) for all plasma-treated samples when compared to both positive and negative controls (p < 0.0001). In single-species biofilms formed by either S. mutans or S. sanguinis, a significant reduction in all exposure times was observed when compared to both positive and negative controls (p < 0.0001). For single-species biofilms formed by S. gordonii, the results indicate total elimination of S. gordonii for all exposure times. Low exposure times of LTP affects single- and multi-species cariogenic biofilms, which indicates that the treatment is a promising source for the development of new protocols for the control of dental caries.

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