Discovery of Novel HCV NS5B polymerase inhibitor, 2‐(3,4‐dimethyl‐5,5‐dioxidobenzo[ e ]pyrazolo[4,3‐ c ][1,2]thiazin‐2(4 H )‐yl)‐ N ‐(2‐fluorobenzyl)acetamide via molecular docking and experimental approach

2021 ◽  
Author(s):  
Hina Khalid ◽  
Sana Shahid ◽  
Somayya Tariq ◽  
Bushra Ijaz ◽  
Usman Ali Ashfaq ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Experimental Approach ◽  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor

2018 ◽  
Vol 22 (10) ◽  
pp. 1393-1408 ◽  
Author(s):  
Jeffrey Bien ◽  
Akin Davulcu ◽  
Albert J. DelMonte ◽  
Kenneth J. Fraunhoffer ◽  
Zhinong Gao ◽  
...  
Keyword(s):  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

Discovery of an irreversible HCV NS5B polymerase inhibitor

2013 ◽  
Vol 23 (24) ◽  
pp. 6585-6587 ◽  
Author(s):  
Qingbei Zeng ◽  
Anilkumar G. Nair ◽  
Stuart B. Rosenblum ◽  
Hsueh-Cheng Huang ◽  
Charles A. Lesburg ◽  
...  
Keyword(s):  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite

2015 ◽  
Vol 25 (5) ◽  
pp. 1135-1139 ◽  
Author(s):  
Pierre L. Beaulieu ◽  
Gordon Bolger ◽  
Martin Duplessis ◽  
Alexandre Gagnon ◽  
Michel Garneau ◽  
...  
Keyword(s):  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase
Sign in / Sign up

Export Citation Format

Share Document