scholarly journals Antagonistic Effects of Interferon-γ and Interleukin-4 on Fibroblast Cultures.

1997 ◽  
Vol 109 (2) ◽  
pp. 158-162 ◽  
Author(s):  
Hervé Serpier ◽  
Philippe Gillery ◽  
Véronique Salmon-Ehr ◽  
Roselyne Garnotel ◽  
Nadine Georges ◽  
...  
Keyword(s):  
Interferon Γ ◽  
Interleukin 4 ◽  
Antagonistic Effects ◽  
Fibroblast Cultures

Regulation of human IgE synthesis. I. Human IgE synthesisin vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-γ

1990 ◽  
Vol 20 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Isabelle Chrétien ◽  
Jér??me Pène ◽  
Francine Brière ◽  
René De Waal Malefijt ◽  
Françoise Rousset ◽  
...  
Keyword(s):  
Interferon Γ ◽  
Interleukin 4 ◽  
Antagonistic Effects ◽  
Ige Synthesis

Increased level of interleukin-13, but not interleukin-4 and interferon-γ in chronic rhinosinusitis with nasal polyps

2014 ◽  
Vol 42 (5) ◽  
pp. 465-471 ◽  
Author(s):  
M. Nabavi ◽  
S. Arshi ◽  
A. Bahrami ◽  
Z. Aryan ◽  
M.H. Bemanian ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Interleukin 13

Interleukin-13 alters the activation state of murine macrophagesin vitro: Comparison with interleukin-4 and interferon-γ

1994 ◽  
Vol 24 (6) ◽  
pp. 1441-1445 ◽  
Author(s):  
Anthony G. Doyle ◽  
Georges Herbein ◽  
Luis J. Montaner ◽  
Adrian J. Minty ◽  
Daniel Caput ◽  
...  
Keyword(s):  
Interferon Γ ◽  
Interleukin 4 ◽  
Interleukin 13

Allergic Rhinitis

1992 ◽  
Vol 13 (9) ◽  
pp. 323-328
Author(s):  
Frank S. Virant
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Signs ◽  
Upper Airway ◽  
Allergic Patient ◽  
The United States ◽  
Specific Ige ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Primary Defect ◽  
Primary Focus

Epidemiology Allergic rhinitis affects as many as 8% to 10% of children in the United States. Many of these children suffer significant morbidity, leading to millions of lost school days annually. Morbidity is amplified when these children concurrently suffer from complications of allergic rhinitis, such as recurrent otitis media or chronic sinus disease. Typically, children who have allergic rhinitis have a family history of atopic disorders. Upper airway allergy may become manifest at any age, but the appearance of symptoms is most common during childhood or young adulthood. Clinical signs of rhinitis may be perennial, seasonal, or episodic, and the primary focus of complaints may relate to secondary problems, including ear, sinus, or lung disease. Pathophysiology In the allergic patient, disease is mediated by the production of antigenspecific IgE by the patient's B lymphocytes. Current research suggests that the primary defect may be the excessive production of interleukin 4 (IL-4) or a deficient level of gamma interferon (γ-INF) when a T-cell is presented with an antigen. This constellation of immunomodulators directs the B-cell to produce IgE rather than the IgG response of the non-allergic patient. Clinical disease occurs when an allergen reacts with antigen-specific IgE on the patient's nasal mast cells. When these factors combine, the mast cell is activated to release a variety of preformed and newly produced mediators, including histamine, leukotrienes, and prostaglandins (Fig 1).

scholarly journals Immune system markers of neuroinflammation in patients with clinical diagnose of neuromyelitis optica

2008 ◽  
Vol 66 (3b) ◽  
pp. 678-684 ◽  
Author(s):  
Soniza Vieira Alves-Leon ◽  
Maria Lucia Vellutini Pimentel ◽  
Gabrielle Sant'Anna ◽  
Fabíola Rachid Malfetano ◽  
Cláudio Duque Estrada ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
B Lymphocyte ◽  
Demyelinating Disease ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Control Group ◽  
Regulatory Cells ◽  
Immunological Parameters ◽  
Healthy Control ◽  
The Central Nervous System

Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system characterized by the association of a serious myelitis and unilateral or bilateral optic neuritis. The present study aimed to analyze the immunological parameters of NMO patients with diagnosis established based on Wingerchuck et al. (1999) criteria. Production of IgG and IgA antibodies to antigens of MBP, PLP 95-116, MOG 92-106, and the cytokines interleukin-4 (IL-4) and interferon-γ (INF-γ) were assessed by Elisa assay. The cohort was formed by 28 NMO patients and a matched healthy control group. NMO patients had significant high levels of IgG to MOG (p<0.0001), PLP (p=0.0002) and MBP (p<0.0001), and solely IgA to MBP (p<0.0001). INF-γ (p=0.61) levels were similar to healthy controls. Increased production of IL-4 (p=0.0084) indicates an important role for this cytokine in the activation of Th2 regulatory cells and of the IgA producers B lymphocyte indicating activation of humoral immunity.

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