Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population‐based studies

BackgroundIt is well established that people with irritable bowel syndrome (IBS) have higher levels of anxiety and depression compared with controls. However, the role of these as risk factors is less clearly established. The aims of this systematic review were to investigate: (1) whether anxiety and/or depression predict IBS onset; (2) the size of the relative risk (RR) of anxiety versus depression in IBS onset. Subgroup analyses explored if methodological factors affected the overall findings.MethodProspective cohort or case–control studies were included if they: (1) focused on the development of IBS in population-based or gastroenteritis cohorts; (2) explored the effects of anxiety and/or depression at baseline as predictors of IBS onset at a future point. In all, 11 studies were included of which eight recruited participants with a gastrointestinal infection. Meta-analyses were conducted.ResultsThe risk of developing IBS was double for anxiety cases at baseline compared with those who were not [RR 2.38, 95% confidence interval (CI) 1.58–3.60]. Similar results were found for depression (RR 2.06, 95% CI 1.44–2.96). Anxiety and depression seemed to play a stronger role in IBS onset in individuals with a gastrointestinal infection although this could be attributed to other differences in methodology, such as use of diagnostic interviews rather than self-report.ConclusionsThe findings suggest that self-reported anxiety and depression provide a twofold risk for IBS onset. There is less support for the role of anxiety or depressive disorder diagnosed using clinical interview. These findings may have implications for the development of interventions focused on IBS prevention and treatment.

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Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.13738 ◽

2016 ◽

Vol 44 (6) ◽

pp. 592-600 ◽

Cited By ~ 79

Author(s):

N. A. Koloski ◽

M. Jones ◽

N. J. Talley

Keyword(s):

Irritable Bowel Syndrome ◽

Prospective Study ◽

Functional Dyspepsia ◽

Population Based ◽

Irritable Bowel

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A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis

Journal of Investigative Medicine ◽

10.1136/jim-2017-000631 ◽

2018 ◽

Vol 66 (4) ◽

pp. 755-761 ◽

Cited By ~ 5

Author(s):

Jeng-Dau Tsai ◽

I-Chung Wang ◽

Te-Chun Shen ◽

Cheng-Li Lin ◽

Chang-Ching Wei

Keyword(s):

Atopic Dermatitis ◽

Irritable Bowel Syndrome ◽

Cohort Analysis ◽

Gastrointestinal Disorder ◽

Population Based ◽

Trend Test ◽

Hazard Ratios ◽

History Of ◽

Irritable Bowel

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured. The incidence of IBS during the study period was 1.45-fold greater (95% CI: 1.32 to 1.59) in the AD cohort than in the non-AD cohort (18.8 vs 12.9 per 10 000 person-years). The AD to non-AD HR of IBS was greater for girls (1.60, 95% CI: 1.39 to 1.85) and children≥12 years (1.59, 95% CI: 1.23 to 2.05). The HR of IBS in AD children increased from 0.84 (95% CI: 0.75 to 0.94) for those with ≤3 AD related visits to 16.7 (95% CI: 14.7 to 18.9) for those with >5 visits (P<0.0001, by the trend test). AD children had a greater risk of developing IBS. Further research is needed to clarify the role of allergy in the pathogenesis of IBS.

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