A single dose of eculizumab terminated life‐threatening haemolysis in idiopathic IgM‐mediated warm autoimmune haemolytic anaemia: A case report

Author(s):  
Mamta Garg ◽  
Siddharth Agarwal ◽  
Mohammed Altohami
2003 ◽  
Vol 24 (1) ◽  
pp. 34-36 ◽  
Author(s):  
N. Tuncer Elmaci ◽  
S. Ratip ◽  
D. ?nce-G�nal ◽  
T. Tanrida?

2019 ◽  
Vol 12 (12) ◽  
pp. e232505 ◽  
Author(s):  
Harriet Williams ◽  
Robin Aitchison

Increasing numbers of patients are now offered immunotherapy as part of their cancer treatment. These treatments, while often very effective, have a wide range of adverse effects that are distinct from those of traditional chemotherapy regimens. Thyroid disease, dermatological disease, colitis and pneumonitis are some of the most commonly reported immune side effects. We present a case of life-threatening de novo autoimmune haemolytic anaemia (AIHA) complicated by immune cholangitis induced by pembrolizumab. An 81-year-old woman with metastatic melanoma completed a two-year course of pembrolizumab in August 2018 and six weeks later presented to hospital with jaundice. Admission haemoglobin (Hb) was 91 g/L, rapidly decreasing to 31 g/L, at which point she required admission to the intensive care unit. AIHA is a rare but potentially life-threatening complication of checkpoint inhibitors and should be considered in patients presenting with anaemia during or after immunotherapy treatment.


1996 ◽  
Vol 11 (5) ◽  
pp. 439-442 ◽  
Author(s):  
ERIC M YOSHIDA ◽  
STEPHEN H NANTEL ◽  
DAVID A OWEN ◽  
PAUL F GALBRAITH ◽  
BAKUL I DALAL ◽  
...  

Author(s):  
Md Nazmul Hasan ◽  
Chowdhury Adnan Sami ◽  
Md Rasul Amin ◽  
Abed Hussain Khan ◽  
Sunil Kumar Biswas

Autoimmune hemolytic anaemia (AIHA) can be caused by many diseases like connective tissue disease, lymphoproliferative disorder, certain infections and various medications. The coronavirus disease 19(COVID-19) can cause an increased risk of thrombosis. But, the association of AIHA with COVID-19 is not well understood. Here, in this case report a 45-year-old man who presented with fever, cough, anaemia and splenomegaly. On further investigation, he was confirmed as severe COVID-19 case with AIHA. Subsequently he was managed with prednisolone with good results. BSMMU J 2021; 14 (COVID -19 Supplement): 57-59


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