scholarly journals Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: sex differences in rats

Author(s):  
Ginevra D’Ottavio ◽  
Ingrid Reverte ◽  
Davide Ragozzino ◽  
Maria Meringolo ◽  
Michele Stanislaw Milella ◽  
...  
2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.


2005 ◽  
Vol 180 (3) ◽  
pp. 414-426 ◽  
Author(s):  
Marilyn E. Carroll ◽  
David K. Batulis ◽  
Kerry L. Landry ◽  
Andrew D. Morgan

2002 ◽  
Vol 161 (3) ◽  
pp. 304-313 ◽  
Author(s):  
Marilyn Carroll ◽  
Andrew Morgan ◽  
Wendy Lynch ◽  
Una Campbell ◽  
Nancy Dess

2020 ◽  
Vol 13 ◽  
pp. 100232
Author(s):  
Krista L. Connelly ◽  
Cassandra C. Wolsh ◽  
Jeffrey L. Barr ◽  
Michael Bauder ◽  
Felix Hausch ◽  
...  

2000 ◽  
Vol 148 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Wendy J. Lynch ◽  
Marilyn E. Carroll

Addiction ◽  
2010 ◽  
Vol 105 (4) ◽  
pp. 727-731 ◽  
Author(s):  
Andrea R. Vansickel ◽  
William W. Stoops ◽  
Craig R. Rush

2013 ◽  
Vol 38 (9) ◽  
pp. 1698-1705 ◽  
Author(s):  
Carolina P Ramôa ◽  
Susan E Doyle ◽  
Diana W Naim ◽  
Wendy J Lynch

2013 ◽  
Vol 231 (8) ◽  
pp. 1753-1762 ◽  
Author(s):  
Victoria Sanchez ◽  
Catherine F. Moore ◽  
Darlene H. Brunzell ◽  
Wendy J. Lynch

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