scholarly journals Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+T cells partly via transforming growth factor-β1

2016 ◽  
Vol 187 (1) ◽  
pp. 113-123 ◽  
Author(s):  
A. E. Anderson ◽  
D. J. Swan ◽  
O. Y. Wong ◽  
M. Buck ◽  
O. Eltherington ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Vitamin D3 ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Tolerogenic Dendritic Cells

scholarly journals Correlation of interleukin 6 and transforming growth factor β1 with peripheral blood regulatory T cells in rheumatoid arthritis patients: a potential biomarker

2018 ◽  
Vol 43 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Majid Khoshmirsafa ◽  
Farhad Seif ◽  
Nader Bagheri ◽  
Pezhman Beshkar ◽  
Mohammad Mousavi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Potential Biomarker

scholarly journals Autophagy Improves the Immunosuppression of CD4+T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1

2016 ◽  
Vol 5 (11) ◽  
pp. 1496-1505 ◽  
Author(s):  
Liangbin Gao ◽  
Shuizhong Cen ◽  
Peng Wang ◽  
Zhongyu Xie ◽  
Zhenhua Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

scholarly journals Oral tolerance: is it all retinoic acid?

2007 ◽  
Vol 204 (8) ◽  
pp. 1737-1739 ◽  
Author(s):  
Harald von Boehmer
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Vitamin A ◽  
Oral Tolerance ◽  
Transforming Growth Factor ◽  
Tolerance Mechanisms ◽  
Cell Homing ◽  
Naïve T Cells

Oral tolerance has been argued to depend on “special” presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-β–dependent conversion of naive T cells into regulatory T (T reg) cells and also directs T reg cell homing to the gut. These results reveal new tolerance mechanisms that will aid the use of T reg cells in the clinic.

Transforming growth factor β1 promotes fibroblast-like synoviocytes migration and invasion via TGF-β1/Smad signaling in rheumatoid arthritis

2019 ◽  
Vol 459 (1-2) ◽  
pp. 141-150 ◽  
Author(s):  
DingJi Zhu ◽  
JinJun Zhao ◽  
AiJu Lou ◽  
Qin Huang ◽  
QingQing OuYang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Migration And Invasion ◽  
Smad Signaling ◽  
Tgf Β1 ◽  
Fibroblast Like Synoviocytes

OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells

2009 ◽  
Vol 131 ◽  
pp. S24
Author(s):  
Gaelle Beriou ◽  
Cristina Costantino ◽  
Clare Baecher-Allan ◽  
David Hafler
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Interleukin 9

scholarly journals A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 ◽  
Vol 183 (6) ◽  
pp. 2669-2674 ◽  
Author(s):  
F Powrie ◽  
J Carlino ◽  
M W Leach ◽  
S Mauze ◽  
R L Coffman
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Th2 Cells ◽  
Tgf Beta ◽  
T Helper ◽  
Cd4 Cells ◽  
Helper Type

A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.

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