Post‐traumatic endophthalmitis: a novel risk scoring system identifying high risk open globe injuries

2021 ◽  
Author(s):  
Christine L. Tan ◽  
Myra B. McGuinness ◽  
Rohan Essex ◽  
Rosie C. H. Dawkins ◽  
Penelope J. Allen
Keyword(s):  
High Risk ◽  
Scoring System ◽  
Open Globe ◽  
Risk Scoring ◽  
Post Traumatic ◽  
Risk Scoring System ◽  
Open Globe Injuries

scholarly journals Development of a Sex-Specific Risk Scoring System for Predicting Cognitive Normal to Mild Cognitive Impairment (SRSS-CNMCI)

2021 ◽  
Author(s):  
Wen Luo ◽  
Hao Wen ◽  
Shuqi Ge ◽  
Chunzhi Tang ◽  
Xiufeng Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
High Risk ◽  
Scoring System ◽  
External Validation ◽  
Scoring Systems ◽  
Cutoff Point ◽  
Risk Scoring ◽  
Risk Scoring System

Abstract Objective: We aim to develop a sex-specific risk scoring system for predicting cognitive normal (CN) to mild cognitive impairment (MCI), abbreviated SRSS-CNMCI, to provide a reliable tool for the prevention of MCI.Methods: Participants aged 61-90 years old with a baseline diagnosis of CN and an endpoint diagnosis of MCI were screened from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database with at least one follow-up. Multivariable Cox proportional hazards models were used to identify risk factors associated with conversion from CN to MCI and to build risk scoring systems for male and female groups. Receiver operating characteristic (ROC) curve analysis was applied to determine the risk probability cutoff point corresponding to the optimal prediction effect. We ran an external validation of the discrimination and calibration based on the Harvard Aging Brain Study (HABS) database.Results: A total of 471 participants, including 240 women (51%) and 231 men (49%), aged 61 to 90 years, were included in the study cohort for subsequent primary analysis. The final multivariable models and the risk scoring systems for females and males included age, APOE ε4, Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). The scoring systems for females and males revealed C statistics of 0.902 (95% CI 0.840-0.963) and 0.911 (95% CI 0.863-0.959), respectively, as measures of discrimination. The cutoff point of high and low risk was 33% in females, and more than 33% was considered high risk, while more than 9% was considered high risk for males. The external validation effect of the scoring systems was good: C statistic 0.950 for the females and C statistic 0.965 for the males. Conclusions: Our parsimonious model accurately predicts conversion from CN to MCI with four risk factors and can be used as a predictive tool for the prevention of MCI.

scholarly journals The Efficacy of Risk Score System Establishment and Methylprednisolone Stratification Treatment for Pre-Engraftment Syndrome after Unrelated Cord Blood Transplantation: A Retrospective (development) and a Prospective (validation) Study

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4501-4501
Author(s):  
Xiaoyu Zhu ◽  
Jiang Zhu ◽  
Baolin Tang ◽  
Kaidi Song ◽  
Linlin Jin ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Risk Score ◽  
Cumulative Incidence ◽  
Scoring System ◽  
Cord Blood Transplantation ◽  
High Risk Factors ◽  
Risk Scoring ◽  
Risk Scoring System ◽  
Different Doses

Introduction Pre-engraftment syndrome (PES) is a common immune reaction prior to neutrophil engraftment after unrelated cord blood transplantation (UCBT), with a unique clinical manifestation of non-infectious fever and skin rash. The reported incidence of PES ranges from 20% to 78%. Although many researchers believe that PES is associated with a high incidence of acute graft-versus-host disease (GVHD) but not with transplant-related mortality (TRM) , relapse, or overall survival (OS), they did not stratify the risk factors of PES, and how to carry out different doses of methylprednisolone (MP) stratified intervention therapy still remains unknown. Method s First, 136 hematological malignancy patients treated with UCBT from April 2000 to February 2012 in our transplantation center were retrospectively analysis. Among them, 92 patients occurred PES. High-risk factors for 180-day TRM in PES patients were established by univariate and multivariate analysis. Then, from January 2013 to August 2016, 221 PES patients were scored according to the risk scoring system and stratified treated with different doses of MP. Finally, in order to validate the efficacy of MP stratification treatment, we conducted a prospective, open label and non-randomized clinical trial including 240 PES patients who underwent UCBT from September 2016 to December 2018. This trial is registered at www.chictr.org.cn as ChiCTR-ONC-16009013. Results The cumulative incidence of neutrophil and platelet engraftment was significantly higher in PES group than non-PES group (97.8% vs 70.5%, P<0.001; 75.0% vs 54.5%, P=0.05). In 92 PES patients, multivariate analysis showed that failed MP treatment, multiple clinical symptoms and early onset of PES were independent high risk factors affecting180-day TRM. One high risk factor was scored as 1. The 92 PES patients were divided into PES-0, PES-1,PES-2 and PES-3, and the higher the score, the higher the TRM (17.7% vs 21.9% vs 62.5% vs 100%,respectively; P<0.001), and the lower the OS (68.3% vs 56.2% vs 25.0% vs 0%, respectively; P<0.001). Then, from January 2013 to August 2016, 221 PES patients were scored as PES-0, PES-1 and PES-2 according to the following two high risk factors (multiple clinical symptoms and early onset of PES) and stratified treated with different doses of MP (0.5mg/kg/d for PES-0, 1mg/kg/d for PES-1 and 2mg/kg/d for PES-2). Compared to the previous PES patients with the same risk score, the 180-day TRM of PES-1 and PES-2 patients was significantly reduced and the OS, disease free survival (DFS), and GVHD-free and Relapse-free survival (GRFS) were significantly increased after stratified treatment. The results in the prospective trial were similar to the retrospective study. In addition, although stratified therapy could significantly improve the prognosis of PES-2 patients cohort, the cumulative incidence of acute GVHD and GRFS are still the worst compared with other risk score patients. Therefore, how to improve the outcomes of PES-2 patients remains to be further studied. Conclusion s PES after UCBT is benefit for engraftment, but should be graded according the risk scoring system. Different doses of MP stratified intervention therapy can significantly improve the prognosis of severe PES patients. The risk scoring system of PES after UCBT and MP stratification treatment are worthy of clinical application. But the cumulative incidence of acute GVHD and GRFS in severe PES patients still need to be ameliorated in the further study. Disclosures No relevant conflicts of interest to declare.

Predicting Depression and Post-Traumatic Stress Symptoms Following Burn Injury: A Risk Scoring System

2021 ◽  
Author(s):  
Olivia R Stockly ◽  
Audrey E Wolfe ◽  
Richard Goldstein ◽  
Kimberly Roaten ◽  
Shelley Wiechman ◽  
...  
Keyword(s):  
Traumatic Stress ◽  
Scoring System ◽  
Burn Injury ◽  
Post Traumatic Stress ◽  
Stress Symptoms ◽  
Burn Survivors ◽  
Risk Scoring ◽  
Post Traumatic ◽  
Risk Scoring System ◽  
Predictors Of Depression

Abstract Depression and post-traumatic stress are common psychiatric comorbidities following burn injury. The purpose of this study was to develop an admission scoring system that assesses the risk of development of depression or post-traumatic symptoms in the burn population. This study is a retrospective review of the prospectively collected Burn Model System National Database. Adult burn survivors enrolled from 2014-2018 (n=486) were included. The primary outcome was the presence of depression or post-traumatic stress symptoms at 6, 12, or 24 months post-injury. Logistic regression analysis was used to identify demographic and clinical predictors of depression and post-traumatic stress symptoms. A risk scoring system was then created based on assigning point values to relevant predictor factors. The study population had a mean age of 46.5±15.8 years, mean burn size of 18.3±19.7%, and was 68.3% male. Prior to injury, 71.3% of the population was working, 47.9% were married, and 50.8% had completed more than a high school education. An 8-point risk scoring system was developed using the following predictors of depression or post-traumatic stress symptom development: gender, psychiatric treatment in the past year, graft size, head/neck graft, etiology of injury, and education level. This study is the first to develop a depression and post-traumatic stress symptom risk scoring system for burn injury. This scoring system will aid in identifying burn survivors at high risk of long-term psychiatric symptoms that may be used to improve screening, monitoring, timely diagnosis and interventions.

A risk scoring system to identify travellers who qualify for pre-exposure rabies vaccination

2020 ◽  
Vol 27 (7) ◽  
Author(s):  
Mieke Croughs ◽  
Patrick Soentjens
Keyword(s):  
High Risk ◽  
Scoring System ◽  
Evidence Based ◽  
Risk Scoring ◽  
Risk Predictors ◽  
Risk Scoring System ◽  
Rabies Vaccination

We want to introduce a free online scoring system to identify high risk travellers who qualify for pre-travel rabies vaccination. The system uses evidence based risk predictors and the probable availability of HRIG at the destination.

scholarly journals MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality

Head & Neck ◽  
2020 ◽  
Vol 42 (8) ◽  
pp. 1699-1712 ◽  
Author(s):  
Angela J. Yoon ◽  
Shuang Wang ◽  
David I. Kutler ◽  
Richard D. Carvajal ◽  
Elizabeth Philipone ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Scoring System ◽  
Early Stage ◽  
Specific Mortality ◽  
Risk Scoring ◽  
Cancer Specific Mortality ◽  
Risk Scoring System

575 Determining Risk Factors Associated with Development of Depression Following Burn Injury

2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S129-S130
Author(s):  
Olivia Stockly ◽  
Audrey E Wolfe ◽  
Shelley A Wiechman ◽  
Kimberly Roaten ◽  
Colleen M Ryan ◽  
...  
Keyword(s):  
High Risk ◽  
Scoring System ◽  
Burn Injury ◽  
Psychological Treatment ◽  
Depression Symptoms ◽  
Post Injury ◽  
Factors Associated ◽  
Depression Risk ◽  
Risk Scoring ◽  
Risk Scoring System

Abstract Introduction Depression symptoms following burn injury are common, however a tool to risk stratify the likelihood of development of these symptoms does not exist. This study aims to examine the demographic and clinical factors associated with depression symptoms at 12 months post-injury. This data will be used to develop a depression risk scoring system. Methods Data from the Burn Model System National Database (2015–2019) were analyzed. Depression subscale scores of the PROMIS-29 were examined at 12 months and those with scores greater than 60 were considered to have depression symptoms. Demographic and clinical characteristics of the study population were compared between those with and without depression symptoms. Predictors of depression symptoms at 12 months post-injury were determined using multivariate logistic regression. Results The analysis included 298 individuals (52 with and 246 without depression symptoms). Those with depression symptoms at 12 months post-injury were more likely to be female, have had psychological treatment in the year prior to injury, and have sustained a suspected self-inflicted burn injury. Those with depression symptoms were less likely to be married or working at the time of injury compared to those without depression symptoms. No differences in age, burn size, race/ethnicity, etiology of injury, or education level were observed between groups (Table 1). Psychological therapy or counseling in the year prior to injury was the only significant predictor of depression symptoms at 12 months post-injury (p= 0.016). Age and female gender approached significance (p=0.092 and p= 0.086, respectively). Conclusions A history of recent pre-injury psychological treatment was the only significant predictor of depressive symptoms found one-year post-injury. Applicability of Research to Practice This data will be used to create a depression risk scoring system to be used at time of acute care admission to identify burn survivors who are at high risk of developing depression. Identifying those at high risk of depression will facilitate appropriate utilization of resources and potential treatment prophylaxis.

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