Local control of 151 head and neck cutaneous squamous cell carcinoma after radiotherapy: a retrospective study on efficacy and prognostic factors

2016 ◽  
Vol 42 (4) ◽  
pp. 851-855 ◽  
Author(s):  
J.B. Terra ◽  
M.B. Gaster ◽  
G.B. Halmos ◽  
J.L. Roodenburg ◽  
B. van der Vegt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Local Control ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

Adjuvant radiation and cetuximab improves local control in head and neck cutaneous squamous cell carcinoma: A phase II study

Head & Neck ◽  
2021 ◽  
Author(s):  
Paul J. Kreinbrink ◽  
Michelle L. Mierzwa ◽  
Brad Huth ◽  
Kevin P. Redmond ◽  
Trisha M. Wise‐Draper ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Phase Ii ◽  
Local Control ◽  
Squamous Cell ◽  
Phase Ii Study ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Adjuvant Radiation

scholarly journals Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck

2021 ◽  
Author(s):  
Alet J.G. Leus ◽  
Marjolijn S. Haisma ◽  
Jorrit B. Terra ◽  
Gilles F.H. Diercks ◽  
Marloes S. Van Kester ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumour Diameter ◽  
Progression Of Disease ◽  
Tumour Characteristics

Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics of younger (< 75 years) and elderly (≥ 75 years) patients and identify age-specific risk factors for progression of disease, comprising local recurrence, nodal metastasis and distant metastasis. Patient and tumour characteristics were compared using χ2 or Fisher’s exact tests. Multivariable competing risk analyses were performed to compare risk factors for progression of disease, incorporating the risk of dying before developing progression of disease. A total of 672 patients with primary cutaneous squamous cell carcinoma of the head and neck were retrospectively included. Larger tumour diameter, worse differentiation grade and deeper invasion were observed in older patients. In elderly patients, but not in younger patients, tumour diameter ≥ 40 mm, moderate differentiation grade and an invasion depth ≥ 2 mm were independent risk factors for progression of disease.

scholarly journals Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Joshua Lubov ◽  
Mathilde Labbé ◽  
Krystelle Sioufi ◽  
Grégoire B. Morand ◽  
Michael P. Hier ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Subcutaneous Fat ◽  
Lymph Node Biopsy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Solar Ultraviolet Radiation

Abstract Background Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a non-melanoma skin cancer that is mostly caused by solar ultraviolet radiation exposure. While it usually has an excellent prognosis, a subset of patients (5%) develops nodal metastasis and has poor outcomes. The aim of this study was to systematically review the literature and evaluate the prognostic factors of HNCSCC in order to better understand which patients are the most likely to develop metastatic disease. Methods A comprehensive literature search was performed on PubMed and EMBASE to identify the studies that evaluated the prognostic factors of HNCSCC. Prognostic factors were deemed significant if they had a reported p-value of < 0.05. Proportions of studies that reported a given factor to be statistically significant were calculated for each prognostic factor. Results The search yielded a total of 958 citations. Forty studies, involving a total of 8535 patients, were included in the final analysis. The pre-operative/clinical prognostic factors with the highest proportion of significance were state of immunosuppression (73.3%) and age (53.3%); while post-operative/pathological prognostic factors of importance were number of lymph nodes involved with carcinoma (70.0%), margins involved with carcinoma (66.7%), and tumor depth (50.0%). Conclusion This systematic review is aimed to aid physicians in assessing the prognosis of HNCSCC and identifying the subsets of patients that are most susceptible to metastasis. It also suggests that immunosuppressed patients with a high-risk feature on biopsy, such as invasion beyond subcutaneous fat, could possibly benefit from a sentinel lymph node biopsy. Graphical abstract

Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck

Head & Neck ◽  
2019 ◽  
Vol 41 (6) ◽  
pp. 1895-1902 ◽  
Author(s):  
Aurora Mirabile ◽  
Rosalba Miceli ◽  
Rosa Gioia Calderone ◽  
Laura Locati ◽  
Paolo Bossi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Metastatic Squamous Cell Carcinoma

P-113 Oncological Outcomes and Prognostication in Cutaneous Squamous Cell Carcinoma of the Head and Neck with Nodal Metastasis

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 1
Author(s):  
Mark D. Wilkie ◽  
Dorota Chudek ◽  
Sankalap Tandon ◽  
Christopher Loh ◽  
Nicholas J. Roland ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Oncological Outcomes
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