Circadian Transcription Factor NPAS2 and the NAD+‐Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward

2022 ◽  
Author(s):  
Darius D. Becker‐Krail ◽  
Puja K. Parekh ◽  
Kyle D. Ketchesin ◽  
Shintaro Yamaguchi ◽  
Jun Yoshino ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nucleus Accumbens ◽  
Circadian Transcription

scholarly journals Wild-Type Circadian Rhythmicity Is Dependent on Closely Spaced E Boxes in the Drosophila timelessPromoter

2001 ◽  
Vol 21 (4) ◽  
pp. 1207-1217 ◽  
Author(s):  
Michael J. McDonald ◽  
Michael Rosbash ◽  
Patrick Emery
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Locomotor Activity ◽  
Circadian Rhythms ◽  
High Amplitude ◽  
Wild Type ◽  
Activity Rhythms ◽  
E Box ◽  
E Boxes ◽  
Circadian Transcription

ABSTRACT Transcriptional regulation plays an important role inDrosophila melanogaster circadian rhythms. The period promoter has been well studied, but the timeless promoter has not been analyzed in detail. Mutagenesis of the canonical E box in the timelesspromoter reduces but does not eliminate timeless mRNA cycling or locomotor activity rhythms. This is because there are at least two other cis-acting elements close to the canonical E box, which can also be transactivated by the circadian transcription factor dCLOCK. These E-box-like sequences cooperate with the canonical E-box element to promote high-amplitude transcription, which is necessary for wild-type rhythmicity.

scholarly journals Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis

Cell Reports ◽  
2020 ◽  
Vol 33 (7) ◽  
pp. 108394
Author(s):  
Suihong Huang ◽  
Ming Ho Choi ◽  
Hao Huang ◽  
Xin Wang ◽  
Yu Chen Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
Circadian Transcription

scholarly journals Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian clock

2017 ◽  
Author(s):  
Anna M. Puszynska ◽  
Erin K. O’Shea
Keyword(s):  
Transcription Factor ◽  
Carbon Metabolism ◽  
Energy Charge ◽  
Light Availability ◽  
Light Conditions ◽  
Energy Status ◽  
Carbon Utilization ◽  
Genome Wide ◽  
Essential Function ◽  
Circadian Transcription

AbstractThe transcription factor RpaA is the master regulator of circadian transcription in cyanobacteria, driving genome-wide oscillations in mRNA abundance. Deletion ofrpaAhas no effect on viability in constant light conditions, but renders cells inviable in cycling conditions when light and dark periods alternate. We investigated the mechanisms underlying this viability defect, and demonstrate that therpaA-strain cannot maintain appropriate energy status at night, does not accumulate carbon reserves during the day, and is defective in transcription of genes crucial for utilization of carbohydrate stores at night. Reconstruction of carbon utilization pathways combined with provision of an external carbon source restores energy charge and viability of therpaA-strain in light/dark cycling conditions. Our observations highlight how a circadian program controls and temporally coordinates essential pathways in carbon metabolism to maximize fitness of cells facing periodic energy limitations.

scholarly journals Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor

2008 ◽  
Vol 22 (3) ◽  
pp. 331-345 ◽  
Author(s):  
H. Reinke ◽  
C. Saini ◽  
F. Fleury-Olela ◽  
C. Dibner ◽  
I. J. Benjamin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Dna Binding ◽  
Differential Display ◽  
Binding Proteins ◽  
Dna Binding Proteins ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Circadian Transcription

scholarly journals Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Anna M Puszynska ◽  
Erin K O'Shea
Keyword(s):  
Transcription Factor ◽  
Carbon Metabolism ◽  
Energy Charge ◽  
Light Availability ◽  
Light Conditions ◽  
Energy Status ◽  
Carbon Utilization ◽  
Genome Wide ◽  
Essential Function ◽  
Circadian Transcription

The transcription factor RpaA is the master regulator of circadian transcription in cyanobacteria, driving genome-wide oscillations in mRNA abundance. Deletion of rpaA has no effect on viability in constant light conditions, but renders cells inviable in cycling conditions when light and dark periods alternate. We investigated the mechanisms underlying this viability defect, and demonstrate that the rpaA- strain cannot maintain appropriate energy status at night, does not accumulate carbon reserves during the day, and is defective in transcription of genes crucial for utilization of carbohydrate stores at night. Reconstruction of carbon utilization pathways combined with provision of an external carbon source restores energy charge and viability of the rpaA- strain in light/dark cycling conditions. Our observations highlight how a circadian output pathway controls and temporally coordinates essential pathways in carbon metabolism to maximize fitness of cells facing periodic energy limitations.

scholarly journals Circadian clock mechanism driving mammalian photoperiodism

2020 ◽  
Author(s):  
S.H. Wood ◽  
M.M. Hindle ◽  
Y. Mizoro ◽  
Y. Cheng ◽  
B.R.C. Saer ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Circadian Clock ◽  
Pars Tuberalis ◽  
Eyes Absent ◽  
Environmental Cue ◽  
Long Duration ◽  
Genome Wide ◽  
Seasonal Habitats ◽  
Circadian Transcription ◽  
Clock Mechanism

AbstractThe annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies support the universality of this so-called coincidence timer, but we lack understanding of the mechanisms involved. Here we show in mammals that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the pituitary, and triggers summer biology through the eyes absent / thyrotrophin (EYA3 / TSH) pathway. Conversely, long-duration melatonin signals on short photoperiods induce circadian repressors including DEC1, suppressing BMAL2 and the EYA3/TSH pathway, triggering winter biology. These actions are associated with progressive genome-wide changes in chromatin state, elaborating the effect of the circadian coincidence timer. Hence, circadian clock-pituitary epigenetic pathway interactions form the basis of the mammalian coincidence timer mechanism. Our results constitute a blueprint for circadian-based seasonal timekeeping in vertebrates.

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