A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia

OBJECTIVES: Neonatal seizures are significant cause of neonatal mortality and morbidity. Current study was planned to study prevalence of adverse outcomes in neonatal seizures and identify its predictors. METHODS: This observational descriptive study was carried out on 220 neonates with seizures. Neonates who succumbed to illness/ death before investigations, or whose maternal records were incomplete were excluded. Blood sugar, serum calcium, serum electrolytes, and USG skull were done in all patients. CT scan, MRI and inborn errors of metabolism profile were done as and when indicated. Adverse outcomes were defined as death, phenobarbitone non responders, or abnormal examination at discharge. Antenatal, perinatal and neonatal predictors of adverse outcomes in neonatal seizures were evaluated. RESULTS: Out of 220 neonates with seizures 76(34.5%) had adverse outcomes. Very low birth weight babies (≤1500 gm) [OR 1.27(CI 0.57–2.84)], microcephaly [OR 5.93 (CI 0.55–64.41)], Apgar score≤3 at 5 minutes [OR 11.28(CI 14.18–30.45)], seizure onset within 24 hours [OR 5.99(CI 12.43–14.78)], meningitis [OR 2.63(CI 0.08–6.39)], septicemia [OR1.22(CI 0.45–3.31)] and abnormal cranial USG [OR 7.95(CI 12.61–24.22)] were significant predictors of adverse outcomes in neonates with seizures. CONCLUSION: Prematurity, very low birth weight, birth asphyxia, meningitis, septicemia and abnormal USG could predict adverse outcomes in neonatal seizures. Improved antenatal and neonatal clinical practices may help reduce adverse outcomes in these patients.

Download Full-text

Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia

Epilepsia ◽

10.1111/epi.16963 ◽

2021 ◽

Author(s):

Alexey S. Pospelov ◽

Tommi Ala‐Kurikka ◽

Samu Kurki ◽

Juha Voipio ◽

Kai Kaila

Keyword(s):

Carbonic Anhydrase ◽

Rat Model ◽

Birth Asphyxia ◽

Carbonic Anhydrase Inhibitors

Download Full-text

Study of Clinical Proﬁle of Neonatal Seizures in Level III NICU

Asian Journal of Clinical Pediatrics and Neonatology ◽

10.47009/ajcpn.2020.8.4.7 ◽

2020 ◽

Vol 8 (4) ◽

pp. 30-35

Author(s):

P. Anil Kumar ◽

V. Ramgopal Rao

Keyword(s):

Neurological Disorders ◽

Clinical Presentation ◽

Perinatal Care ◽

Birth Asphyxia ◽

Close Monitoring ◽

Neonatal Seizures ◽

Before And After ◽

Clonic Seizures ◽

The Impact ◽

Comprehensive History

Background: During the neonatal age, seizures are the most distinctive sign of neurological disease. Convulsive symptoms are the most promi- nent forms of neonatal neurological disorders. The goal of this research was to have a better view of the epidemiology, etiology, incidence, forms and mortality of neonatal seizures in our hospital. This research was undertaken to evaluate the prevalence, forms of neonatal seizures, etiology, occurrence period and correlation with etiology, and to establish the mortality correlated with neonatal seizures. For research the etiology and its etiological connection, the occurrence of neonatal seizures. Subjects and Methods: A comprehensive history was collected for the antenatal, natal, postnatal and family history. Age of initiation, form, duration and amount of seizures, consciousness before and after the seizures were taken. Comprehensive neonate examination was performed after detailed history. Relevant investigations were carried out depending upon clinical presentation. Results: In our analysis of 200 neonatal seizures, 194 had one of the four classically identified neonatal seizures. Multifocal clonic seizures were among the most common type of seizures 36% (72 cases) followed by subtle 27% (54 cases), GTS 26% (52 cases), Myoclonic 7% (15 cases), mixed type of seizures 3% (6 cases) and focal clonic seizures 1% (2 cases). Conclusion: Because neonatal seizures are most frequently due to birth asphyxia, better antenatal and perinatal care reduces birth asphyxia and if mothers are identified as high-risk. The impact of neonatal seizures is thereby minimized. Subtle seizures are the most frequent form of psychiatric seizure; thus, close monitoring of newborns at risk is important.

Download Full-text

NEONATAL SEIZURES;

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.05.2503 ◽

2018 ◽

Vol 21 (05) ◽

pp. 1048-1053

Author(s):

Arshad Mahmood ◽

Syed Qamar Zaman ◽

Shahid Mahmud

Keyword(s):

Cerebral Palsy ◽

Neurodevelopmental Outcome ◽

Birth Asphyxia ◽

Unknown Etiology ◽

Neonatal Seizures ◽

Inborn Errors ◽

Cross Sectional ◽

Normal Delivery ◽

Female Ratio

Objective: To study the types, etiology and long term neurodevelopmentaloutcome in neonates with seizures. Study Design: A descriptive cross-sectional study. Placeand Duration of Study: PNS Shifa Naval hospital Karachi from Jan 2011 to Feb 2014. StudyPopulation: Ninety six neonates of either gender presented with seizures at NICU PNS ShifaNaval hospital Karachi were studied. Method: All neonates with seizures were evaluated.The seizures were classified according to the simiology. They were investigated according toNICU protocol to confirm the underlying diagnosis and timely management. The patients afterdischarge were regularly followed up for one year to assess the long term neurodevelopmentaloutcome. Results: A total of 96 neonates with seizures were studied and it was observedthat 60 (62.5%) were male babies and 56 (58.33%) were term with a male to female ratio of1.6:1. Majority of the neonatal seizures were seen in 1stweek of life (85%). The most commontype of seizures was clonic 40 (41.67%) followed by subtle 20 (20.84%), mixed 16 (16.67%),tonic 10 (10.41%), myoclonic 5 (5.20%) and unclassified 5 (5.20%). Antiepileptics were usedin 82 (85.41%) patients. Phenobarbitone 49 (59.76%) was most commonly prescribed drug.The most common cause of seizures was birth asphyxia 48 (50%) followed by metabolic 16(16.68%), sepsis 10 (10.41%), intracranial hemorrhage 6 (6.25%), bilirubin encephalopathy 4(4.16%), inborn errors of metabolism 2 (2.08%), birth trauma 2 (2.08%) and unknown etiology 5(5.20%). 25 (26.04%) patients develop adverse neurodevelopmental outcome i.e. cerebral palsywith epilepsy 10 (40%) and cerebral palsy without epilepsy 05 (20%), developmental delay 10(40%). Mortality in the study was 12 (12.5%). Conclusions: Clonic seizures are commonestin neonates apart from infants and children who have GTCS. The most common etiology ofseizures in neonates is birth asphyxia. Phenobarbitone is still the most commonly prescribedantiepileptic. Quick assessment, timely diagnosis and aggressive management according tothe etiology are necessary to prevent the morbidity and mortality associated with neonatalseizures. Long term neurodevelopmental outcome is worse in patients with birth asphyxiaespecially with low Apgar score at 5 minutes. Normal delivery and birth asphyxia were the majorrisk factors for cerebral palsy

Download Full-text

Faculty Opinions recommendation of A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.739240007.793584319 ◽

2021 ◽

Author(s):

Wolfgang Löscher

Keyword(s):

Rat Model ◽

Birth Asphyxia ◽

Brain Hypoxia ◽

Term Birth

Download Full-text

Time-dependent effect of oligomeric amyloid-β (1–42)-induced hippocampal neurodegeneration in rat model of Alzheimer’s disease

Neurological Research ◽

10.1080/01616412.2018.1544745 ◽

2018 ◽

Vol 41 (2) ◽

pp. 139-150 ◽

Cited By ~ 8

Author(s):

Chennakesavan Karthick ◽

Saravanan Nithiyanandan ◽

Musthafa Mohamed Essa ◽

Gilles J Guillemin ◽

Swaminathan K Jayachandran ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Rat Model ◽

Amyloid Β ◽

Time Dependent ◽

Dependent Effect ◽

Model Of Alzheimer’S Disease ◽

Time Dependent Effect ◽

Hippocampal Neurodegeneration

Download Full-text

A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia

Epilepsia ◽

10.1111/epi.16790 ◽

2020 ◽

Author(s):

Tommi Ala‐Kurikka ◽

Alexey Pospelov ◽

Milla Summanen ◽

Aleksander Alafuzoff ◽

Samu Kurki ◽

...

Keyword(s):

Rat Model ◽

Birth Asphyxia ◽

Brain Hypoxia ◽

Term Birth

Download Full-text

Clinico- Biochemical Profile of Neonatal Seizure

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v28i1.1398 ◽

1970 ◽

Vol 28 (1) ◽

pp. 7-9 ◽

Cited By ~ 2

Author(s):

GS Shah ◽

MK Singh ◽

S Budhathoki ◽

BK Kalakheti ◽

DD Baral

Keyword(s):

Neonatal Intensive Care ◽

Birth Asphyxia ◽

Etiological Factor ◽

Neonatal Seizure ◽

Test Results ◽

Neonatal Seizures ◽

Chi Square ◽

Common Cause ◽

Multiparous Women ◽

Biochemical Abnormalities

Objectives: The present study was undertaken to study the incidence, etiological factor, and days of onset, clinical types and biochemical abnormalities in babies having neonatal seizures. Materials and Methods: This is a retrospective, observational hospital based study. Ninety neonates, who developed seizures before 28 days of life and admitted to neonatal intensive care unit and nursery with neonatal seizure, were evaluated for incidence, etiological factor, clinical types and biochemical abnormalities found in neonatal seizure. The variables were analysed using Chi- Square and student t- test. Results: The incidence of neonatal seizure was 10.3/ 1000 live births. The seizures were common in male babies. 65 (72.2%) neonates were born to multiparous women while 35 (38%) were born to primigravidas. In birth asphyxia (n= 40), the most common type of seizure observed was subtle seizure 20 (50%), followed by focal clonic 10 (25%) and multifocal clonic 5 (12.5%). Tonic type of seizure was observed in 3 (7.5%) and myoclonic in 2 (5%). Meningitis and septicaemia was the second most common cause of neonatal seizure observed in our study. Among metabolic abnormalities hypoglycaemia was found in 20 (22%) and hypocalcaemia in 10 (11%). Conclusion: The commonest cause of seizure was birth asphyxia presenting within 72 hours of life. Among infection septicaemia and meningitis was the most common cause leading to neonatal seizure. Among biochemical abnormalities the most common cause of seizure observed in our study was hypoglycaemia and hypocalcaemia. Subtle seizures were the commonest type of seizure observed in this study. Key words: Neonatal seizure, biochemical disturbances in seizure. DOI = 10.3126/jnps.v28i1.1398 J. Nepal Paediatr. Soc. Vol.28(1) p.7-9

Download Full-text