Editorial Comment to Novel cut‐off values of time from diagnosis to systematic therapy predict the overall survival and the efficacy of targeted therapy in renal cell carcinoma: A long‐term, follow‐up, retrospective study

Author(s):  
Hiroyuki Konaka
2018 ◽  
Vol 118 (9) ◽  
pp. 1176-1178 ◽  
Author(s):  
Robert J. Motzer ◽  
Bernard Escudier ◽  
Thomas Powles ◽  
Christian Scheffold ◽  
Toni K. Choueiri

2018 ◽  
Vol 143 (5) ◽  
pp. 643-647 ◽  
Author(s):  
Tsung-Heng Tsai ◽  
Wen-Ying Lee

Succinate dehydrogenase (SDH)–deficient renal cell carcinoma is a recently recognized distinct subtype of renal cell carcinoma in the 2016 World Health Organization classification. It is associated with SDH gene germline mutations, which also cause paraganglioma/pheochromocytoma, gastrointestinal stromal tumor, and pituitary adenoma. The tumor most commonly presents in young adulthood. The tumors are arranged in solid nests or in tubules and frequently show cystic change. The tumors are composed of cuboidal to oval cells with round nuclei, dispersed chromatin, and inconspicuous nucleoli. The cytoplasm is eosinophilic or flocculent but not truly oncocytic. The most distinctive histologic feature is the presence of cytoplasmic vacuoles or inclusions. Loss of SDH subunit B immunostaining is needed for a definite diagnosis. The prognosis is good for low-grade tumors but worse for tumors with high-grade nuclei, sarcomatoid change, or coagulative necrosis. Long-term follow-up is indicated.


Cancer ◽  
2020 ◽  
Vol 126 (18) ◽  
pp. 4156-4167 ◽  
Author(s):  
Robert J. Motzer ◽  
Bernard Escudier ◽  
Saby George ◽  
Hans J. Hammers ◽  
Sandhya Srinivas ◽  
...  

2012 ◽  
Vol 11 (3) ◽  
pp. 387-394 ◽  
Author(s):  
C. A. Jilg ◽  
Hartmut P. H. Neumann ◽  
S. Gläsker ◽  
O. Schäfer ◽  
C. Leiber ◽  
...  

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