Fraction of positive cores in prostate needle biopsy is significantly predictive of pathological stage in radical prostatectomy

2009 ◽  
Vol 54 (3) ◽  
pp. 374-375
Author(s):  
Fadi Brimo ◽  
Robin T Vollmer ◽  
Tarek A Bismar
Keyword(s):  
Radical Prostatectomy ◽  
Needle Biopsy ◽  
Pathological Stage ◽  
Prostate Needle Biopsy

scholarly journals Significance of nuclear factor - kappa beta activation on prostate needle biopsy samples in the evaluation of Gleason score 6 prostatic carcinoma indolence

2020 ◽  
Vol 54 (2) ◽  
pp. 194-200
Author(s):  
Marko Zupancic ◽  
Boris Pospihalj ◽  
Snezana Cerovic ◽  
Barbara Gazic ◽  
Primoz Drev ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Cutoff Point ◽  
Nuclear Factor ◽  
Pathological Stage ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens ◽  
Biochemical Progression ◽  
Nuclear Factor Kappa Beta

AbstractBackgroundThe goal of our study was to find out whether the immunohistochemical expression of nuclear factor-kappa beta (NF-κB) p65 in biopsy samples with Gleason score 3 + 3 = 6 (GS 6) can be a negative predictive factor for Prostate cancer (PCa) indolence.Patients and methodsStudy was conducted on a retrospective cohort of 123 PCa patients with initial total PSA ≤ 10 ng/ml, number of needle biopsy specimens ≥ 8, GS 6 on biopsy and T1/T2 estimated clinical stage who underwent laparoscopic radical prostatectomy and whose archived formalin-fixed and paraffin-embedded (FFPE) prostate needle biopsy specimens were used for additional immunohistochemistry staining for detection of NF-κB p65. Both cytoplasmic and nuclear NF-κB p65 expression in biopsy cores with PCa were correlated with postoperative pathological stage, positive surgical margins, GS and biochemical progression of disease.ResultsAfter follow-up of 66 months, biochemical progression (PSA ≥ 0.2 ng/ml) occurred in 6 (5.1%) patients, 3 (50%) with GS 6 and 3 (50%) with GS 7 after radical prostatectomy. Both cytoplasmic and nuclear NF-κB p65 expressions were not significantly associated with pathological stage, positive surgical margin and postoperative GS. Patients with positive cytoplasmic NF-kB reaction had significantly more frequent biochemical progression than those with negative cytoplasmic NF-kB reaction with PSA 0.2 ng/ml as cutoff point (p = 0.015) and a trend towards more biochemical progression with PSA ≥ 0.05 ng/ml as cutoff point (p = 0.068).ConclusionsCytoplasmic expression of NF-κB is associated with more biochemical progression and might be an independent prognostic factor for recurrence-free survival (RFS), but further studies including larger patient cohorts are needed to confirm these initial results.

scholarly journals Significance of nuclear factor kappa beta activation on prostate needle biopsy samples in the evaluation of Gleason score 6 prostatic carcinoma indolence

2019 ◽  
Author(s):  
Marko Zupančič ◽  
Boris Pospihalj ◽  
Snežana Cerović ◽  
Barbara Gazić ◽  
Primož Drev ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Surgical Margins ◽  
Cutoff Point ◽  
Positive Surgical Margin ◽  
Pathological Stage ◽  
Positive Surgical Margins ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens

Abstract Background. Prostate cancer (PCa) is the most common cancer in men in developed European countries. Majority of men newly diagnosed with PCa are candidates for primary curative therapy, either with radical prostatectomy (RP) or radiation. However, many PCa are low risk, even indolent and these patients are candidates for active surveillance, so the prediction of such cancers is needed to avoid overtreatment. The main goal of our study was to find out whether the immunohistochemical expression of NF-κB p65 in biopsy samples with Gleason score 3+3=6 (GS 6) can be a negative predictive factor for PCa indolence. Methods. Study was based on a retrospective cohort of 178 PCa patients with initial total PSA ≤ 10 ng/ml, number of needle biopsy specimens ≥8, GS 6 on biopsy and T1/T2 estimated clinical stage who underwent laparoscopic radical prostatectomy and whose archived formalin-fixed and paraffin-embedded (FFPE) prostate needle biopsy specimens were used for additional immunohistochemistry staining for detection of NF-κβ p65. Both cytoplasmatic and nuclear NF-κB p65 expression in biopsy cores with PCa were correlated with postoperative pathological stage, positive surgical margins, GS and biochemical progression (BP) of disease. The final analysis involved 123 patients regarding the postoperative stage, surgical margins and GS and 118 regarding the BP. Results. Postoperative pathological stage 3 was noticed in 27 (22%) and positive surgical margins were detected in 13 patients (10,6%). After median follow-up of 66 months, BP (PSA ≥ 0,05 ng/ml) occurred in 20 (16,9%) patients, 11 (55%) with GS 6 after RP and 9 (45%) with GS 7. Cytoplasmatic nor nuclear NF-κB p65 expressions were not significantly associated with pathological stage, positive surgical margin and postoperative GS. Patients with positive cytoplasmic NF-kB reaction had significantly more BP compared to those with negative cytoplasmic NF-kB reaction with PSA 0,2 ng/ml as cutoff point (p=0,015) and a trend towards more BP with PSA ≥ 0,05 ng/ml as cutoff point (p=0,068). Conclusions. Cytoplasmic expression of NF-κB is associated with more BP and might be an independent prognostic factor for recurrence-free survival (RFS), but further studies including larger patient cohorts are needed to confirm these initial results.

PREOPERATIVE PROSTATE NEEDLE BIOPSY p27 CORRELATES WITH SUBSEQUENT RADICAL PROSTATECTOMY p27, GLEASON GRADE AND PATHOLOGICAL STAGE

2000 ◽  
pp. 1987-1991 ◽  
Author(s):  
GEORGE V. THOMAS ◽  
MATTHEW I. SCHRAGE ◽  
LISA ROSENFELT ◽  
JIN HEE KIM ◽  
GIRI SALUR ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Needle Biopsy ◽  
Gleason Grade ◽  
Pathological Stage ◽  
Prostate Needle Biopsy

PREOPERATIVE PROSTATE NEEDLE BIOPSY p27 CORRELATES WITH SUBSEQUENT RADICAL PROSTATECTOMY p27, GLEASON GRADE AND PATHOLOGICAL STAGE

2000 ◽  
Vol 164 (6) ◽  
pp. 1987-1991 ◽  
Author(s):  
GEORGE V. THOMAS ◽  
MATTHEW I. SCHRAGE ◽  
LISA ROSENFELT ◽  
JIN HEE KIM ◽  
GIRI SALUR ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Needle Biopsy ◽  
Gleason Grade ◽  
Pathological Stage ◽  
Prostate Needle Biopsy

Is systematic 10 core prostate needle biopsy enough for treatment determination of localized prostate cancer?

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 163-163
Author(s):  
Ryo Kishimoto ◽  
Ryuta Tanimoto ◽  
Kensuke Bekku ◽  
Yasuyuki Kobayashi ◽  
Shin Ebara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multivariate Analysis ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Chi Square ◽  
Prostate Needle Biopsy ◽  
Significant Difference ◽  
Chi Square Test

163 Background: To evaluate whether the systematic 10 cores prostate needle biopsy is enough for determination of NCCN risk classification (NRC), we analyzed migration of Gleason score (GS), cancer location, and NRC between pre and postoperative periods in a cohort of patients who underwent radical prostatectomy. Methods: A total of 197 patients were included in this study. These patients were divided into three groups along the number of biopsy cores: less than 10 (L), 10, and more than 10 (M). We compared between three groups about Gleason score, cancer location and NCCN risk classification change (CC) between prostate biopsy and radical prostatectomy specimen. Statistical analysis were performed with chi-square test, and multiple logistic regression with p<0.05, and Bonferroni correction with p<0.017 considered significant difference. Results: The rate of CC in L, 10, M was 55.1%, 43.0%, 26.5%, respectively. On chi-square test rates of CC were significantly different between three groups (P=0.035), but rates of Gleason score and cancer location were not. On univariate analysis, PSA (Odds rate (OR) 0.872 p<0.001), preoperative NRC (low vs. intermediate, and poor, OR 0.157 and 0.241, p<0.001), prostate volume (normal vs. mild or moderate, OR 1.989 p=0.025), the number of biopsy cores (L vs. M, OR 0.293 p=0.011), GS (6 vs. 8, OR 2.374 p=0.021) were correlated with CC. On multivariate analysis, the most important independent predictive factors for CC were preoperative NRC (low vs. intermediate, p<0.001, OR 0.198, 95% CI 0.09-0.45) and PSA (p=0.007, OR 0.903, 95%CI 0.83-0.98), but the number of biopsy cores was not associated CC significantly. Conclusions: Although multivariate analysis showed no significant difference, the more biopsy cores reduced the risk of CC. Systematic 10 core biopsy might be insufficient for accurate diagnosis and treatment decision of prostate cancer.

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