Risk factors for Attention Deficit Hyperactivity Disorder among school-aged children in Iran

2008 ◽  
Vol 15 (4) ◽  
pp. A30-A30
Author(s):  
Sg Shooshtari ◽  
P Raeissi ◽  
Tm Mayer

Key Points Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition with genetic and environmental causes. Risk factors include preterm birth and maternal substance use during pregnancy. Because of the prevalence of this condition, primary care clinicians should develop the skills to diagnose and manage this condition in patients from age 4 years through adolescence. The 3 subtypes of ADHD are predominantly inattentive, predominantly hyperactive-impulsive, and combined inattentive and hyperactive-impulsive. No cardiac workup is necessary beyond conducting a thorough cardiac history before initiating stimulant medication. Stimulant medications are the most effective treatment of ADHD in school-aged children and adolescents.







Author(s):  
Lucia Margari ◽  
Francesco Margari ◽  
Francesco Craig ◽  
Donatella La Tegola ◽  
Emilia Matera ◽  
...  


2004 ◽  
Vol 79 (9) ◽  
pp. 1124-1131 ◽  
Author(s):  
Jennifer L. St. Sauver ◽  
William J. Barbaresi ◽  
Slavica K. Katusic ◽  
Robert C. Colligan ◽  
Amy L. Weaver ◽  
...  


2007 ◽  
Vol 96 (9) ◽  
pp. 1269-1274 ◽  
Author(s):  
Tania Das Banerjee ◽  
Frank Middleton ◽  
Stephen V. Faraone


Author(s):  
Pangajam Ponnuswamy ◽  
Ann Sarah Paul ◽  
Aneesha Brigitte Jose

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder most commonly found in childhood with its core symptoms manifesting as inattention, impulsiveness, and hyperactivity. As ADHD generates a substantial rate of burden to the society in terms of economic and medical resources used, priority is given to explore the risk factors that contributes towards the multifactorial origin of this disorder to offer possible preventive and therapeutic interventions. With heritability accounting for 75% to 80% of the variability seen in ADHD, the remaining are explained through environmental risk factors that are exposed during critical period of pre-, peri-, and postnatal development. Though literature on the risk factors have been mostly controversial, certain associations have been made with regards to ADHD pathophysiology.



2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Søren D. Østergaard ◽  
Betina B. Trabjerg ◽  
Thomas D. Als ◽  
Clara Albiñana Climent ◽  
Florian Privé ◽  
...  

Abstract The objective of the present study was to investigate whether the polygenic liability for attention-deficit/hyperactivity disorder (ADHD) and the psychosocial environment impact the risk of ADHD in interaction or independently of each other. We conducted a register- and biobank-based cohort study of 13,725 individuals with ADHD and 20,147 randomly drawn population-based controls. These 33,872 cohort members were genotyped on the Infinium PsychChip v1.0 array (Illumina). Subsequently, we calculated the polygenic risk score (PRS) for ADHD and extracted register data regarding the following risk factors pertaining to the psychosocial environment for each cohort member at the time of birth: maternal/paternal history of mental disorders, maternal/paternal education, maternal/paternal work status, and maternal/paternal income. We used logistic regression analyses to assess the main effects of the PRS for ADHD and the psychosocial environment on the risk of ADHD. Subsequently, we evaluated whether the effect of the PRS and the psychosocial environment act independently or in interaction upon the risk of ADHD. We found that ADHD was strongly associated with the PRS (odds ratio: 6.03, 95%CI: 4.74–7.70 for highest vs. lowest 2% liability). All risk factors pertaining to the psychosocial environment were associated with an increased risk of ADHD. These associations were only slightly attenuated after mutual adjustments. We found no statistically significant interaction between the polygenic liability and the psychosocial environment upon the risk of ADHD. In conclusion, we found main effects of both polygenic liability and risk factors pertaining to the psychosocial environment on the risk of ADHD—in the expected direction.



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