Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration

2012 ◽  
Vol 40 (6) ◽  
pp. 617-625 ◽  
Author(s):  
Michal Kramer ◽  
Murat Hasanreisoglu ◽  
Anna Feldman ◽  
Ruth Axer-Siegel ◽  
Paulina Sonis ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Aqueous Humour ◽  
Age Related Macular Degeneration ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Age Related

scholarly journals Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients

2020 ◽  
Vol 12 ◽  
pp. 251584142095168
Author(s):  
Ramazan Kürşad Zor ◽  
Serpil Erşan ◽  
Erkut Küçük ◽  
Gamze Yıldırım ◽  
İsmail Sarı
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Age Related

Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants ( n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group ( p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group ( p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.

scholarly journals Aqueous humour proteins and treatment outcomes of anti-VEGF therapy in neovascular age-related macular degeneration

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229342
Author(s):  
Yusuke Arai ◽  
Hidenori Takahashi ◽  
Satoru Inoda ◽  
Xue Tan ◽  
Shinichi Sakamoto ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Treatment Outcomes ◽  
Aqueous Humour ◽  
Age Related Macular Degeneration ◽  
Anti Vegf ◽  
Age Related

scholarly journals Early local activation of complement in aqueous humour of patients with age-related macular degeneration

Eye ◽  
2019 ◽  
Vol 33 (12) ◽  
pp. 1859-1864 ◽  
Author(s):  
L. Altay ◽  
V. Sitnilska ◽  
T. Schick ◽  
G. Widmer ◽  
G. Duchateau-Nguyen ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Aqueous Humour ◽  
Age Related Macular Degeneration ◽  
Local Activation ◽  
Age Related

scholarly journals Changes in multiple cytokine concentrations in the aqueous humour of neovascular age-related macular degeneration after 2 months of ranibizumab therapy

2017 ◽  
Vol 102 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Shinichi Sakamoto ◽  
Hidenori Takahashi ◽  
Xue Tan ◽  
Yuji Inoue ◽  
Yoko Nomura ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Aqueous Humour ◽  
Medical Center ◽  
Interleukin 10 ◽  
Age Related Macular Degeneration ◽  
Induction Phase ◽  
Care Organization ◽  
Neovascular Amd ◽  
Age Related ◽  
Chemokine Ligand

PurposeTo determine changes in multiple cytokine concentrations in the anterior chamber during the induction phase of ranibizumab treatment in patients with neovascular age-related macular degeneration (AMD).MethodsThis prospective study included 48 treatment-naïve neovascular AMD eyes of 48 patients who received three consecutive monthly injections of ranibizumab at the Japan Community Health Care Organization Tokyo Shinjuku Medical Center between November 2010 and August 2012. We collected ~0.2 mL aqueous humour before the first and third (2 months later) injections. Controls were 80 eyes with cataracts without retinal disease. The cytokines C-X-C motif chemokine ligand 1 (CXCL1), interferon-γ-induced protein 10 (IP-10), C-X-C motif chemokine ligand 12 (CXCL12), C-X-C motif chemokine ligand 13 (CXCL13), monocyte chemoattractant protein 1 (MCP-1), CCL11, C-C motif chemokine ligand 11 (CCL11), interleukin-6 (IL-6), interleukin-10 (IL-10) and matrix metalloproteinase 9 (MMP-9) were analysed using multiplex cytokine assays.ResultsMean ages of the patients with AMD and controls were 73 and 75 years, respectively, and 31 (65%) and 37 (46%) subjects were men, respectively. Polypoidal choroidal vasculopathy was found in 27 eyes (56%). Mean concentrations of cytokines in aqueous humour in patients with neovascular AMD before the first and third ranibizumab injections were as follows (in pg/mL): CXCL1, 8.4 and 3.3; IP-10, 110 and 55; CXCL12, 480 and 240; CXCL13, 9.2 and 2.6; MCP-1, 620 and 220; CCL11, 7.1 and 2.8; IL-6, 5.9 and 1.6; IL-10, 0.15 and 0.015 (all p<0.0001), and MMP-9, 0.92 and 1.5 (p=0.0216), respectively. Concentrations of all cytokines decreased significantly after two consecutive ranibizumab injections, except for MMP-9, which increased significantly.ConclusionsAfter two monthly consecutive antivascular endothelial growth factor injections, inflammatory cytokine levels in the aqueous humour of the eyes with AMD were strongly suppressed, while MMP-9 levels increased.

Monocyte Chemoattractant Protein-1-Induced Protein in Age-Related Atrial Fibrillation and Its Association with Circulating Fibrosis Biomarkers

Cardiology ◽  
2019 ◽  
Vol 142 (4) ◽  
pp. 244-249 ◽  
Author(s):  
Gege Zhang ◽  
Asiyanmu Abuduoufu ◽  
Xianhui Zhou ◽  
Yaodong Li ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Correlation Analysis ◽  
The Elderly ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Type I ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Age Related

Background: Atrial fibrillation (AF), for which age is an independent risk factor, is the most common persistent arrhythmia. Monocyte chemoattractant protein-1-induced protein (MCPIP), a transcription factor that induces a series of inflammation and cell death procedures, has been indicated to cause cardiomyocyte death in ischemic cardiomyopathy. The objective of this research was to investigate the relationship between age-related AF and MCPIP. Methods: A total of 1,084 participants were included in this study, including 542 AF patients and 542 non-AF controls. Their medical histories were collected and analyzed. Moreover, blood samples were collected, and ELISA tests for expression of the inflammatory factor MCPIP and the fibrosis biomarkers pro-collagen type III N-terminal peptide (PIIINP) and type I collagen C-terminal telopeptide (ICTP) were conducted. Finally, a correlation analysis of these inflammatory factors and biomarkers was performed based on the ELISA results. Results: We compared the echocardiography results of AF patients and found that the left ventricular ejection fraction and left atrial appendage velocity decreased with age (p < 0.05). Moreover, ELISA analysis of these samples showed that the expression of MCPIP was the highest in elderly patients with AF (p < 0.05), and there was no significant difference in expression between adult AF patients and elderly controls (p > 0.05). Finally, the correlation analysis demonstrated that the expressions of MCPIP, PIIINP, and ICTP were positively correlated in the elderly AF patient group, the adult AF group, and the elderly control group (p < 0.05). Conclusion: MCPIP expression was higher in age-related AF than in the other patient groups and it was associated with AF-induced fibrosis.

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