No association between chromosome 12p13 single nucleotide polymorphisms and early-onset ischemic stroke

2010 ◽  
Vol 8 (8) ◽  
pp. 1858-1860 ◽  
Author(s):  
L. A. LOTTA ◽  
B. GIUSTI ◽  
C. SARACINI ◽  
A. VESTRINI ◽  
M. VOLPE ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

The association of single nucleotide polymorphisms of the maternal cystathionine-β-synthase gene with early-onset preeclampsia

2016 ◽  
Vol 6 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Kim M. Holwerda ◽  
M. Susanne Weedon-Fekjær ◽  
Anne C. Staff ◽  
Ilja M. Nolte ◽  
Harry van Goor ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Early Onset Preeclampsia

Su1074 – Association Between Single Nucleotide Polymorphisms in Il-1β, Il-6 and Il-10 and Early-Onset Colorectal Cancer in Puerto Rican Hispanics

2019 ◽  
Vol 156 (6) ◽  
pp. S-501-S-502
Author(s):  
Jorge J. Cruz-Cruz ◽  
Maria Gonzalez-Pons ◽  
Noe E. Crespo ◽  
Lorena Gonzalez-Sepulveda ◽  
Lenis N. Rovira Torres ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Puerto Rican ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Early Onset Colorectal Cancer

scholarly journals Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population

2008 ◽  
Vol 25 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Weihua Meng ◽  
Anne E. Hughes ◽  
Chris C. Patterson ◽  
Christine Belton ◽  
Frank Kee ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Cause Of Death ◽  
Early Onset ◽  
Nucleotide Polymorphisms ◽  
Irish Population ◽  
Single Nucleotide ◽  
The World ◽  
Family Based

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p= 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p= 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

Sign in / Sign up

Export Citation Format

Share Document