Recovery from major depression: the role of support from family, friends, and spiritual beliefs

2005 ◽  
Vol 111 (2) ◽  
pp. 125-132 ◽  
Author(s):  
E. H. Nasser ◽  
J. C. Overholser
Keyword(s):  
Major Depression ◽  
Spiritual Beliefs

Anhedonia and major depression: The role of agomelatine

2012 ◽  
Vol 22 ◽  
pp. S505-S510 ◽  
Author(s):  
Massimo Di Giannantonio ◽  
Giovanni Martinotti
Keyword(s):  
Major Depression

How is childhood emotional abuse related to major depression in adulthood? The role of personality and emotion acceptance

2017 ◽  
Vol 72 ◽  
pp. 98-109 ◽  
Author(s):  
Philipp Schulz ◽  
Thomas Beblo ◽  
Hedda Ribbert ◽  
Leona Kater ◽  
Stephanie Spannhorst ◽  
...  
Keyword(s):  
Major Depression ◽  
Emotional Abuse ◽  
Childhood Emotional Abuse

Depression, Anhedonia, and Psychomotor Symptoms: The Role of Dopaminergic Neurocircuitry

CNS Spectrums ◽  
2008 ◽  
Vol 13 (7) ◽  
pp. 561-565 ◽  
Author(s):  
Dan J. Stein
Keyword(s):  
Major Depression ◽  
Dopaminergic System ◽  
Therapeutic Interventions ◽  
Gene Variants ◽  
Characteristic Features ◽  
Psychomotor Symptoms ◽  
Affective Disturbances ◽  
The Way

ABSTRACTThe heterogeneity of major depression suggests that multiple neurocircuits and neurochemicals are involved in its pathogenesis. Anhedonia and psychomotor symptoms are, however, particularly characteristic features of major depression and may provide insights into its underlying psychobiology. Importantly, these symptoms appear to be mediated by dopaminergic mesolimbic and mesostriatal projections, the function of which is, in turn, influenced by key gene variants and environment stressors. Indeed, there is growing evidence of the way in which the dopaminergic system is associated with cognitive-affective disturbances in depression, and provides a useful target for therapeutic interventions. At the same time, a range of other systems are likely to contribute to the psychobiology of this condition.

scholarly journals Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

2017 ◽  
Vol 8 ◽  
Author(s):  
Frank Euteneuer ◽  
Katharina Dannehl ◽  
Adriana del Rey ◽  
Harald Engler ◽  
Manfred Schedlowski ◽  
...  
Keyword(s):  
Major Depression ◽  
Immune Alterations

scholarly journals The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder

CNS Spectrums ◽  
2016 ◽  
Vol 22 (3) ◽  
pp. 282-289 ◽  
Author(s):  
Volker A. Coenen ◽  
Thomas E. Schlaepfer ◽  
Peter Goll ◽  
Peter C. Reinacher ◽  
Ulrich Voderholzer ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Major Depression ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Reward System ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

Deep brain stimulation (DBS) is a promising putative modality for the treatment of refractory psychiatric disorders such as major depression and obsessive-compulsive disorder (OCD). Several targets have been posited; however, a clear consensus on differential efficacy and possible modes of action remain unclear. DBS to the supero-lateral branch of the medial forebrain bundle (slMFB) has recently been introduced for major depression (MD). Due to our experience with slMFB stimulation for MD, and because OCD might be related to similar dysfunctions of the reward system, treatment with slMFB DBS seams meaningful. Here we describe our first 2 cases together with a hypothetical mode of action.We describe diffusion tensor imaging (DTI) fiber tractographically (FT)-assisted implantation of the bilateral DBS systems in 2 male patients. In a selected literature overview, we discuss the possible mode of action. Both patients were successfully implanted and stimulated. The follow-up time was 12 months. One patient showed a significant response (Yale–Brown Obsessive-Compulsive Scale [YBOCS] reduction by 35%); the other patient reached remission criteria 3 months after surgery (YBOCS<14) and showed mild OCD just above the remission criterion at 12 months follow-up.While the hypermetabolism theory for OCD involves the cortico–striato–thalamo–cortical (CSTC) network, we think that there is clinical evidence that the reward system plays a crucial role. Our findings suggest an important role of this network in mechanisms of disease development and recovery. In this uncontrolled case series, continuous bilateral DBS to the slMFB led to clinically significant improvements of ratings of OCD severity. Ongoing research focuses on the role of the reward system in OCD, and its yet-underestimated role in this underlying neurobiology of the disease.

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