Factors associated with emotional response of parents at the time of diagnosis of Down syndrome

The outbreak of the coronavirus disease in 2019 (COVID-19) has greatly impacted the life and mental health of many people globally. The objective of this study was to investigate the factors associated with preventive behaviors and mental health among Chinese adults during their home quarantine in the COVID-19 period. An online questionnaire survey was administered in March 2020. The study participants were adults aged between 18 and 70 years old from 31 provinces in China. Of the 3878 participants, 1314 reported moderate levels of anxiety, and the remaining participants reported moderate to severe levels of anxiety. Findings revealed that females aged between 18 and 30 years old who had higher educational qualifications, greater levels of preventive knowledge, trust in the government, and resided in urban and medium-risk areas (R2 = 0.100, F = 27.97, p < 0.001) were more likely to exhibit preventive behaviors. In contrast, a higher negative emotional response was generally seen in males who had low levels of preventive knowledge and behaviors, higher risk perception of infection, lower trust in the government, and unhealthy lifestyles (R2 = 0.127, F = 32.33, p < 0.001). In addition, the high-risk perception of infection was positively associated with high odds of anxiety (AOR = 1.17, 95% CI: 1.10–1.24), whereas a greater level of preventive knowledge (AOR = 0.36, 95% CI: 0.19–0.70) and behaviors (AOR = 0.69, 95% CI: 0.57–0.84), higher trust in the government’s COVID-19 pandemic mitigation measures (AOR = 0.77, 95% CI: 0.71–0.83), and a healthier lifestyle (AOR = 0.89, 95% CI: 0.79–0.99) were negatively associated with high odds of anxiety. Results showed that a lower level of anxiety and negative emotional response were associated with better preventive behaviors against COVID-19, which were influenced by preventive knowledge, risk perception, trust in the government’s COVID-19 pandemic mitigation measures, and healthy lifestyle. Findings in this study could help formulate health interventions for vulnerable groups related to gendered vulnerabilities in the COVID-19 environment to improve their mental health and preventive behaviors, especially during the period of a pandemic.

Download Full-text

Factors associated with malocclusions in children and adolescents with Down syndrome

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2007.09.014 ◽

2008 ◽

Vol 133 (4) ◽

pp. 489.e1-489.e8 ◽

Cited By ~ 28

Author(s):

Ana Cristina Borges Oliveira ◽

Saul Martins Paiva ◽

Mônica Rodrigues Campos ◽

Dina Czeresnia

Keyword(s):

Down Syndrome ◽

Children And Adolescents ◽

Factors Associated

Download Full-text

Prospective Study of 168 Infants with Transient Abnormal Myelopoiesis with Down Syndrome: Japan Pediatric Leukemia/Lymphoma Study Group, TAM-10 Study

Blood ◽

10.1182/blood.v126.23.1311.1311 ◽

2015 ◽

Vol 126 (23) ◽

pp. 1311-1311 ◽

Cited By ~ 4

Author(s):

Hideki Muramatsu ◽

Tomoyuki Watanabe ◽

Daisuke Hasegawa ◽

Park Myoung-ja ◽

Shotaro Iwamoto ◽

...

Keyword(s):

Risk Factors ◽

Down Syndrome ◽

Gestational Age ◽

Early Death ◽

Study Group ◽

Pediatric Leukemia ◽

Factors Associated ◽

Transient Abnormal Myelopoiesis ◽

Lymphoma Study Group ◽

Wbc Count

Abstract Introduction: Transient abnormal myelopoiesis (TAM) occurs in approximately 10% of infants with Down syndrome (DS). Although most patients achieve spontaneous remission, some develop severe organ failure and die in their infancy. Previous studies have identified several risk factors associated with early death in such cases, including a high white blood cell (WBC) count, early gestational age, and ascites (Massey GV, 2006; Muramatsu H, 2008; Klusmann JH, 2008). Although chemotherapy with low-dose cytosine arabinoside (LDCA) has been applied for severe cases, its side effect profile has not been fully demonstrated in an adequate number of patients. Here we prospectively analyzed 168 infants with DS who were diagnosed with TAM, including 52 patients treated with LDCA. We assessed the efficacy and safety of LDCA therapy in these cases. Patient and Methods: Between May 2011 and February 2014, 168 infants (90 boys and 78 girls) were diagnosed with TAM and prospectively registered in the Japan Pediatric Leukemia/Lymphoma Study Group (JPLSG) TAM-10 study. GATA1 gene mutations were identified in all except 7 patients who had a very low blast percentage. The median (range) of WBC count was 38.6 (2.4-478.7) × 109 cells/L, and the median (range) of gestational age was 37 (29-40) weeks. Thirty one (18%) patients developed anasarca at diagnosis, and 23 (14%) patients developed acute megakaryocytic leukemia. Results: The overall survival (OS) rate and the event-free survival (EFS) rate at 1 year from diagnosis [95% confidential interval (CI)] were 86.3% (80.1-90.7), and 80.2% (73.2-85.5), respectively. Univariate analysis identified the following covariates as risk factors associated with early death (<9 months): early gestational age [<37 weeks; hazard ratio (HR; 95% CI) = 4.482 (1.826-10.997), p = 0.001], parenchymal bleeding [HR (95% CI) = 5.746 (2.241-14.734), p < 0.001], anasarca [HR (95% CI) = 13.344 (5.419-32.860), p < 0.001], and high WBC count [ ≥100 × 109 cells/L; HR (95% CI) = 8.013 (3.354-19.144), p < 0.001]. The multivariate Cox hazard model identified anasarca and a high WBC count (≥100 × 109 cells/L) as independent risk factors for early death. With regard to the 52 patients who received LDCA therapy, only anasarca remained an independent risk factor for early death. Subgroup analysis in patients with a high WBC count (≥100 × 109 cells/L; n = 36) showed that LDCA therapy significantly improved survival [1-year OS (95% CI) = 78.3% (55.4-90.3; n = 23) vs. 38.5% (14.1-62.8; n = 13); p = 0.009]. In contrast, the survival rate of patients with anasarca (n = 31) did not improve on receiving LDCA therapy [1-year OS (95% CI) = 58.3% (27.0-80.1; n = 12) vs. 47.4% (24.4-67.3; n = 19); p = 0.525]. The most common side effect of LDCA was neutropenia (grade 3-4 = 59%), and one patient died due to tumor lysis syndrome. Conclusion: This prospective study confirmed that a high WBC count and anasarca are risk factors for early death in patients with DS who were diagnosed with TAM. Although LDCA therapy could significantly improve the survival rate in patients with a high WBC count, it failed to change the prognosis of patients with anasarca. A new treatment modality is required for most severe TAM patients with anasarca at diagnosis. Disclosures No relevant conflicts of interest to declare.

Download Full-text

Factors associated with intelligence in young children with Down syndrome

Paediatrica Indonesiana ◽

10.14238/pi52.4.2012.194-9 ◽

2012 ◽

Vol 52 (4) ◽

pp. 194

Author(s):

Frieda Handayani Kawanto ◽

Soedjatmiko Soedjatmiko ◽

Aryono Hendarto

Keyword(s):

Down Syndrome ◽

Young Children ◽

Intervention Program ◽

Body Height ◽

Poverty Line ◽

Intervention Programs ◽

Cross Sectional ◽

Children With Down Syndrome ◽

Factors Associated ◽

Iq Tests

Introduction Despite the considerable number of children withDo\Vll syndrome in Indonesia, there is little data available on thesuccess of intervention programs. This study was performed todefine factors affecting the intelligence of young children withDo\Vll syndrome.Objective To determine factors associated Mth lower intelligencein children with Down syndrome, including growth parametersand participation in intervention programs.Methods This cross􀁃sectional study was undertaken fromDecember 2010 to March 2011. Subjects were 60 childrenwith Down syndrome aged 2􀁃6 years who were enrolled inan intervention program at both the Medical RehabilitationDepartment, Cipto Mangunkusumo Hospital, and the Growthand Development Clinic, Harapan Kita Women's and Children'sHospital. Parents' data was obtained through self history􀁃takingand perusal of medical records. Subjects' anthropometricdata (body weight, body height, and head circumference) wasobtained through measurements using calibrated instruments.A psychologist administered IQ tests on the subjects. Results ofthe anthropometric and IQ tests were given to parents one weekfollowing the examinations.Results From the 111 children with Down syndromeregistered in the intervention programs, 60 children (36boys and 24 girls) met the inclusion criteria. The mean ageof subjects was 4 years 6 months. Most subjects were well􀁃nourished. Fifty􀁃five subjects had microcephaly. Eighty􀁃twopercent of subjects participated in the program regularly and70% of subjects had started in the program at less than 1 yearof age. Subjects' mean IQ was 52.8. Analysis showed thatgirls, subjects who were overweight and obese, subjects withmicrocephaly, those with irregular attendance in the program,and those living under the poverty line were at highest riskfor severe mental retardation.Conclusion Factors associated v.ith the intelligence in childrenwith Down syndrome were female gender, overweight/obesity, severe microcephaly, below􀁃poverty line economic status, andirregular participation in the program. [Paediatr Indones.2012;52:194-9].

Download Full-text

FACTORS ASSOCIATED WITH INFANT MORTALITY IN CHILDREN WITH DOWN SYNDROME IN ITALY. A MULTIVARIATE STUDY

Pediatric Research ◽

10.1203/00006450-198911000-00080 ◽

1989 ◽

Vol 26 (5) ◽

pp. 512-512

Author(s):

Carlo Corchia ◽

Pieraaolo Mastroiacovo ◽

Roberto Bertollini

Keyword(s):

Down Syndrome ◽

Infant Mortality ◽

Children With Down Syndrome ◽

Factors Associated ◽

Multivariate Study

Download Full-text

Factors associated with early and late onset Alzheimer disease in Down syndrome

Alzheimer s & Dementia ◽

10.1002/alz.056526 ◽

2021 ◽

Vol 17 (S10) ◽

Author(s):

Florence Lai ◽

Cassandra Wang ◽

Nathaniel Mercaldo ◽

H Diana Rosas

Keyword(s):

Down Syndrome ◽

Alzheimer Disease ◽

Late Onset ◽

Factors Associated

Download Full-text

Factors associated with referral for polysomnography in children with Down syndrome

Sleep Medicine ◽

10.1016/j.sleep.2021.03.019 ◽

2021 ◽

Author(s):

Poornima R. Wijayaratne ◽

Katrina Williams ◽

Margot J. Davey ◽

Rosemary S.C. Horne ◽

Gillian M. Nixon

Keyword(s):

Down Syndrome ◽

Children With Down Syndrome ◽

Factors Associated

Download Full-text

IMPACT OF COPING ON MICROSOCIAL RISK FACTORS FOR ADDICTIVE AND MIXED ANXIETY-DEPRESSIVE DISORDERS IN STUDENTS

Siberian Medical Journal ◽

10.29001/2073-8552-2018-33-4-125-130 ◽

2019 ◽

Vol 33 (4) ◽

pp. 125-130 ◽

Cited By ~ 1

Author(s):

I. V. Voevodin

Keyword(s):

Risk Factors ◽

Social Support ◽

Emotional Response ◽

Depressive Disorders ◽

Reference Group ◽

Stressful Situation ◽

Psychoactive Substance ◽

Factors Associated ◽

Psychoactive Substance Use ◽

The Impact

The microsocial factors associated with parent family, reference group, and groupmates affect the development of addictive and mixed anxiety-depressive disorders in students. Students, carriers of each of microsocial risk factors, were characterized by specific motives for psychoactive substance use and specific non-adaptive realizing coping associated with social support modules (26.1%) and prognosis of the stress situation development (21.7%). At the same time, the impact of microsocial risk factors might be weakened by adaptive moderating coping, which manifested in the modules of distraction from the stressful situation (20.6% of cases) and the emotional response to the situation (15.7%). Also, in the realizing and moderating copings, the module of rational assessment of a stressful situation (17.4% of cases for realizing coping and 14.7% for moderating coping) was of value.

Download Full-text

Factors associated with intelligence in young children with Down syndrome

Paediatrica Indonesiana ◽

10.14238/pi52.4.2012.02 ◽

2012 ◽

Vol 52 ◽

pp. 194-199

Author(s):

Frieda Handayani Kawanto ◽

Soedjatmiko Soedjatmiko ◽

Aryono Hendarto

Keyword(s):

Down Syndrome ◽

Young Children ◽

Children With Down Syndrome ◽

Factors Associated

Download Full-text