Biorelevant in-vitro performance testing of orally administered dosage forms

2012 ◽  
Vol 64 (7) ◽  
pp. 919-930 ◽  
Author(s):  
Christos Reppas ◽  
Maria Vertzoni
Keyword(s):  
Performance Testing ◽  
Dosage Forms ◽  
In Vitro Performance

Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms—Workshop Report

2014 ◽  
Vol 31 (7) ◽  
pp. 1867-1876 ◽  
Author(s):  
Christos Reppas ◽  
Horst-Dieter Friedel ◽  
Amy R. Barker ◽  
Lucinda F. Buhse ◽  
Todd L. Cecil ◽  
...  
Keyword(s):  
Performance Testing ◽  
Dosage Forms ◽  
Workshop Report ◽  
In Vitro Performance

scholarly journals Amorphous Formulation and in Vitro Performance Testing of Instantly Disintegrating Buccal Tablets for the Emergency Delivery of Naloxone

2016 ◽  
Vol 13 (5) ◽  
pp. 1688-1698 ◽  
Author(s):  
Abdulmalik Alqurshi ◽  
Zahrae Kumar ◽  
Rebecca McDonald ◽  
John Strang ◽  
Asma Buanz ◽  
...  
Keyword(s):  
Performance Testing ◽  
Amorphous Formulation ◽  
Buccal Tablets ◽  
In Vitro Performance

scholarly journals An Update to Dialysis-Based Drug Release Testing—Data Analysis and Validation Using the Pharma Test Dispersion Releaser

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2007
Author(s):  
Marc-Phillip Mast ◽  
Harshvardhan Modh ◽  
Julian Knoll ◽  
Elena Fecioru ◽  
Matthias G. Wacker
Keyword(s):  
Extracellular Vesicle ◽  
Quality Parameters ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Release Assay ◽  
Important Quality ◽  
Oral Dosage Forms ◽  
Development And Validation ◽  
In Vitro Performance

Currently, a wide variety of complex non-oral dosage forms are entering the global healthcare market. Although many assays have been described in recent research, harmonized procedures and standards for testing their in vitro performance remain widely unexplored. Among others, dialysis-based techniques such as the Pharma Test Dispersion Releaser are developed for testing the release of drugs from nanoparticles, liposomes, or extracellular vesicle preparations. Here, we provide advanced strategies and practical advice for the development and validation of dialysis-based techniques, including documentation, analysis, and interpretation of the raw data. For this purpose, key parameters of the release assay, including the hydrodynamics in the device at different stirring rates, the selectivity for particles and molecules, as well as the effect of excipients on drug permeation were investigated. At the highest stirring rate, a more than twofold increase in the membrane permeation rate (from 0.99 × 10−3 to 2.17 × 10−3 cm2/h) was observed. Additionally, we designed a novel computer model to identify important quality parameters of the dialysis experiment and to calculate error-corrected release profiles. Two hydrophilic creams of diclofenac, Voltaren® Emulgel, and Olfen® gel, were tested and provide first-hand evidence of the robustness of the assay in the presence of semisolid dosage forms.

scholarly journals In Vitro Performance Testing of the Novel Medspray® Wet Aerosol Inhaler Based on the Principle of Rayleigh Break-up

2007 ◽  
Vol 25 (5) ◽  
pp. 1186-1192 ◽  
Author(s):  
Anne H. de Boer ◽  
Jeroen Wissink ◽  
Paul Hagedoorn ◽  
Iwan Heskamp ◽  
Wilbur de Kruijf ◽  
...  
Keyword(s):  
Performance Testing ◽  
The Novel ◽  
Break Up ◽  
Aerosol Inhaler ◽  
In Vitro Performance

In Vitro Performance Testing of a Pediatric Oxygenator With an Integrated Pulsatile Pump

ASAIO Journal ◽  
2012 ◽  
Vol 58 (4) ◽  
pp. 420-425 ◽  
Author(s):  
Ralf Borchardt ◽  
Peter Schlanstein ◽  
Ilona Mager ◽  
Jutta Arens ◽  
Thomas Schmitz-Rode ◽  
...  
Keyword(s):  
Performance Testing ◽  
Pulsatile Pump ◽  
In Vitro Performance

scholarly journals In Vitro Performance Testing of Nanoparticulate Drug Products for Parenteral Administration

2019 ◽  
Vol 26 (3) ◽  
pp. 28-37
Author(s):  
Elena Fecioru ◽  
Martin Klein ◽  
Johannes Krämer ◽  
Matthias G. Wacker
Keyword(s):  
Performance Testing ◽  
Parenteral Administration ◽  
Drug Products ◽  
In Vitro Performance

In Vitro Performance Testing of Legacy and ENFit Gastrostomy Tube Devices Under Gravity Flow Conditions

2018 ◽  
Vol 42 (8) ◽  
pp. 1334-1341 ◽  
Author(s):  
Suvajyoti Guha ◽  
Nivetita Ravi ◽  
Joshua S. Silverstein ◽  
Jeffrey Cooper ◽  
Matthew R. Myers
Keyword(s):  
Performance Testing ◽  
Gastrostomy Tube ◽  
Gravity Flow ◽  
Flow Conditions ◽  
In Vitro Performance

scholarly journals Towards Standardized Dissolution Techniques for In Vitro Performance Testing of Dry Powder Inhalers

2018 ◽  
Vol 25 (3) ◽  
pp. 6-18 ◽  
Author(s):  
Andreea Floroiu ◽  
Martin Klein ◽  
Johannes Krämer ◽  
Claus-Michael Lehr
Keyword(s):  
Performance Testing ◽  
Dry Powder Inhalers ◽  
Dry Powder ◽  
In Vitro Performance
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