scholarly journals Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model mice

2021 ◽  
Author(s):  
Nicole P Kasica ◽  
Xueyan Zhou ◽  
Qian Yang ◽  
Xin Wang ◽  
Wenzhong Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Model ◽  
Eef2 Kinase

scholarly journals Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

2019 ◽  
Vol 129 (2) ◽  
pp. 820-833 ◽  
Author(s):  
Brenna C. Beckelman ◽  
Wenzhong Yang ◽  
Nicole P. Kasica ◽  
Helena R. Zimmermann ◽  
Xueyan Zhou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Model ◽  
Eef2 Kinase

scholarly journals Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lishu Duan ◽  
Mufeng Hu ◽  
Joseph A. Tamm ◽  
Yelena Y. Grinberg ◽  
Fang Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Disease Model ◽  
Mitochondrial Morphology ◽  
Individual Gene ◽  
Human Genes ◽  
Future Drug ◽  
Tau Aggregation

AbstractAlzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to assess 1525 human genes related to tau aggregation, autophagy and mitochondria. This work revealed (I) a network of tau aggregation modulators including the NF-κB pathway and inflammatory signaling, (II) a correlation between mitochondrial morphology, respiratory function and transcriptomics, (III) machine learning predicted novel roles of genes and pathways in autophagic processes and (IV) individual gene function inferences and interactions among biological processes via multi-feature clustering. These studies provide a platform to interrogate underexplored aspects of AD biology and offer several specific hypotheses for future drug discovery efforts.

scholarly journals A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer’s disease model

2014 ◽  
Vol 6 (3) ◽  
pp. 26 ◽  
Author(s):  
Shuang Wang ◽  
Yang Yu ◽  
Shuang Geng ◽  
Dongmei Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Disease Model ◽  
Brain Inflammation

scholarly journals Olfactory Functions Scale with Circuit Restoration in a Rapidly Reversible Alzheimer's Disease Model

2013 ◽  
Vol 33 (30) ◽  
pp. 12208-12217 ◽  
Author(s):  
N. Cheng ◽  
L. Bai ◽  
E. Steuer ◽  
L. Belluscio
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Model
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